DRSC/TRiP Functional Genomics Resources

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Protein Alignment CIT and Pkc98E

DIOPT Version :10

Sequence 1:XP_011536085.1 Gene:CIT / 11113 HGNCID:1985 Length:2084 Species:Homo sapiens
Sequence 2:NP_524545.2 Gene:Pkc98E / 43428 FlyBaseID:FBgn0003093 Length:739 Species:Drosophila melanogaster


Alignment Length:354 Identity:119/354 - (33%)
Similarity:187/354 - (52%) Gaps:44/354 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    89 ELQP---SAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILS 150
            |.:|   |..||....::|.|.|.:|.:..:|.|.:|||:||:||.|::..:.|.....|:.||:
  Fly   397 ETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILA 461

Human   151 RSTS-PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHL 214
            .:.: |::..|...||..:.|:.||||..||||:..:.:.. :.:.:...||.||:.||:..:|.
  Fly   462 LAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKAR-RFEASRAAFYAAEVTLALQFLHT 525

Human   215 MGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGT 279
            .|.::||:|.:|||:|:.||.||.|||...:...|.|:.... .|||||:|||:|.      :..
  Fly   526 HGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTF-CGTPDYIAPEILK------EQE 583

Human   280 YGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPK----VSSDFLDLIQS 340
            ||...|||::||:.|||:.|:.||........|::||:        ||..    :|.:.:.:::.
  Fly   584 YGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMH--------DDVLYPVWLSREAVSILKG 640

Human   341 LLC-GQKERLKFEG----LCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSNFDEPEKNSWVS 398
            .|. ..::||...|    :..||||:|:||..:  ||..|||.|.:|:..|.:|||.    .:..
  Fly   641 FLTKNPEQRLGCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDA----EFTK 701

Human   399 SSPCQLSPSG------FSGEELPFVGFSY 421
            ..|. |:|.|      .:.:|  |.|||:
  Fly   702 EDPV-LTPIGNEVVRCINQDE--FAGFSF 727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CITXP_011536085.1 STKc_CRIK 95..422 CDD:270752 116/345 (34%)
CwlO1 442..>598 CDD:443091
SMC_prok_B 531..1343 CDD:274008
CRIK 1401..1456 CDD:410364
PH 1486..1605 CDD:459697
CNH 1650..1946 CDD:214481
Pkc98ENP_524545.2 C2_PKC_epsilon 1..134 CDD:175981
C1_nPKC_epsilon-like_rpt1 171..230 CDD:410385
C1_nPKC_epsilon-like_rpt2 250..304 CDD:410388
STKc_nPKC_epsilon 412..729 CDD:270743 114/339 (34%)
Blue background indicates that the domain is not in the aligned region.

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