Protein Alignment CIT and Pka-C3

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_730083.2
• Gene: Pka-C3 / 39733
• FlyBaseID: FBgn0000489
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 333
• Identity: 102/333 - (30%)
• Similarity: 174/333 - (52%)
• Gaps: 45/333 - (13%)

Human    77 VRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSF 141
            ||||            ...|:::...||.|.|..|.:.|::.:....|||::....::..:|:..
  Fly   266 VRKY------------HLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEH 318

Human   142 FEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELI 206
            .:.|||||.....|::..|:::.:|.::||::.:|..||:|.:.| |...:.......||.||::
  Fly   319 VKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYL-RNAGKFTSQTSNFYAAEIV 382

Human   207 LAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTV 271
            .|:..:|.:..|:||:||||:|::|.||:|:.|||.|.|:........    |||:|:|||::
  Fly   383 SALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFAKKLRDRTWTLC----GTPEYIAPEII-- 441

Human   272 MNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAE----GTSARTFNNIMNFQRFLKFPDDPKVSS 332
               ..|| :....|||::||:.|||:.|..||.:    |...:..:..:.::|.:    ||...
  Fly   442 ---QSKG-HNKAVDWWALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHM----DPIAK- 497

Human   333 DFLDLIQSLLCGQK-ERL-----KFEGLCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSNFD 389
               |||:.||...: :||     ..:.:..|.:|..::||::  :...||.:|.:..|.||.|||
  Fly   498 ---DLIKKLLVNDRTKRLGNMKNGADDVKRHRWFKHLNWNDVYSKKLKPPILPDVHHDGDTKNFD 559

Human   390 E-PEKNSW 396
            : |||: |
  Fly   560 DYPEKD-W 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	98/315 (31%)
		CwlO1	442..>598	CDD:443091
		SMC_prok_B	531..1343	CDD:274008
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
Pka-C3	NP_730083.2	STKc_PRKX_like	272..563	CDD:270763	94/309 (30%)