Protein Alignment CIT and sti

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Alignment Length: 2107
• Identity: 565/2107 - (26%)
• Similarity: 972/2107 - (46%)
• Gaps: 490/2107 - (23%)

Human    18 EPIASRASRLNLFFQGKP----------------PFMTQQQMSPLS-----------REGILDAL 55
            |||:.|.:|||....||.                |..|::.:.|:|           |||:|||.
  Fly     6 EPISVRTARLNNLILGKGAGVCAKPAGSASGSGIPASTRRSIVPVSTTSAAVAEAICREGLLDAF 70

Human    56 FVLFEECSQPALMK-IKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKAT 119
            .:|:.||.:..|.| .::::.||.|:...|.|.::|:.:|.||.:::|:|.|:|..|.:|.|:.|
  Fly    71 CLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVVERQT 135

Human   120 GDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLS 184
            .||||||.: ||:::...||   :|||:|:|...|.|:..|||||||.::|||||||.|||||||
  Fly   136 NDIYAMKKI-KKSVVTTSQV---KEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLS 196

Human   185 LLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSN 249
            |::|: ...||:|.:||||||.:|:|::|.||||||||||||||:||.|||||.|||:||.::.:
  Fly   197 LMSRH-GPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRD 260

Human   250 KMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGL-----------DCDWWSVGVIAYEMIYGRSPF 303
            ..|.:..|:|||||:|||:|..::     ||.|           .||:||:|:|.||:|...:||
  Fly   261 GHVLSLSPVGTPDYIAPELLQTIS-----TYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPF 320

Human   304 AEGTSARTFNNIM------NFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFFSK 362
            .|.....|::.|:      :.:..:.||.|.|||.::.:||:||:....:||.:|.:..|||||:
  Fly   321 HEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRLSYERIKNHPFFSE 385

Human   363 IDWNNIRNSPPPFVPTLKSDDDTSNFDE-------PEKNSWVSSSPCQLSPSGFSGEELPFVGFS 420
            |.|.:||:..||.:||::||||||||::       .|:.....|....:..:.|||::|||:|:|
  Fly   386 IPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPFIGYS 450

Human   421 YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKE----LQDSQDKCHKMEQEMTRLH---RR 478
            :..              ::..|.:::.::||..|.||    |:..:::...::|::.|..   |:
  Fly   451 FVH--------------MEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRK 501

Human   479 VSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLE-QARMEVSQEDDKALQLLHDI 542
            ......|::..::|:|  :.|:.:.|:.:.  :|.|.:..::|: .|:::......|...:...:
  Fly   502 TDNKSQVVADAKMEIK--KLQQIIKEKTME--LTTCKTQIKTLQSSAKIDEEMWSKKEATITDLL 562

Human   543 REQSRKLQEIK---EQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAT 604
            |...:|.:|.|   ||.|:.|:.:.:       ::|.|..::.|..|.          ||..|..
  Fly   563 RLNRQKYEEAKIASEQRYEKQLADKK-------QELASTLQKLDAREL----------EFNAKFE 610

Human   605 ECQH---KLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAK 666
            ||:|   ||...||..:....:..|.|..:.||:.::.||.|:         :.|:|.:.:|.::
  Fly   611 ECKHLSMKLQNYKDMLQQIKEQNLKSETNHEEQRRQMAELYEQ---------KLTDLRKKVRDSQ 666

Human   667 E---RAERELEKLQNREDSSEGIRKKLVEAEE-RRHSLENKVKRL-------ETMERRENRLKDD 720
            :   |...|:::::...|.|....|...||:. ...::|..::||       ..:...:.:|:..
  Fly   667 DTNRRMTMEIKEIRTELDESISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETK 731

Human   721 IQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYE------EKIKVLDNQIKKD-L 778
            :|.|..:.|::..:...||.:.:.|:...|..|..|..:...||      .::..:::|::.| |
  Fly   732 LQLKENETQEVRAECHRLERELQLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLL 796

Human   779 ADKET-----------------LENMMQRHEEEAHEKGKILSEQKA-------MINAMDSKIRS- 818
            |.||:                 ||.|::|..|::....|..|.:|.       |:...:.|:..
  Fly   797 AAKESENHQKGRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDK 861

Human   819 ----LEQRIVELSEANKLAANSSLFTQRNMKAQEEMISE---LRQQKFYLETQAGKLEAQNRKLE 876
                .||.|||...|.  .||.||:  :..|..||.:||   |.::....|.:..|::..:.:.:
  Fly   862 LAAVREQMIVERQAAR--TANLSLW--KVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQ 922

Human   877 EQLEKISHQDHSDKNRLLELETRL----REVSLEH------EEQKLELKRQLTELQLSLQERESQ 931
            ..|:....:....::|:.||:..|    |:|..||      |:::::.|.::.|...::...|.|
  Fly   923 RMLKTSQEETRQRESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQ 987

Human   932 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 996
            .|.|:       .:|||.::..:..|.|.:..|:.|...|::.::..|    ||.|   |:::|.
  Fly   988 ETELR-------QKLRQIQSRFDGVTLEQKNTIRELQEEREKSRKAND----SCLV---LQKELK 1038

Human   997 QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC 1061
            |||:        ||   ::|..|....|.             ::||.|..|.|:::..::.|:
  Fly  1039 QLTD--------NF---QRLKYACSITDS-------------QLTEVETMLKSEQERNKSQKS-- 1077

Human  1062 TMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQR--- 1123
                    .|:.|:::|.|:..|                  :.:|::.|.|.:..:..|:||
  Fly  1078 --------QLDTLHEKLRERNDQ------------------LTDLRKQLTTVESEKRLAEQRAQV 1116

Human  1124 ITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE-MNARSLQQKLETE 1187
            :......:.|.:||.:.:::|.|..|.||       ::.|...:::..:|: .||....|..::.
  Fly  1117 LASEIDELRLNLKEQQKKLVAQQDQLVEQ-------TNALFATQERAELLDGQNANYEAQTADSN 1174

Human  1188 RELKQRLLEEQAKLQQQMDLQKNHIFRL---TQGLQEALDRADLLKTERSDLEYQLENIQVLYSH 1249
            ||:.. |.||.|::..::..:|..:..|   .:||:.|  :|: |..|...|:..|...:..|..
  Fly  1175 REMVS-LKEENARILSELFHKKEEVGNLQAEIRGLESA--QAN-LHAEIDSLQDTLAEKEQFYVQ 1235

Human  1250 EKVKMEGTISQQTKLIDFLQAKM-DQPAKKKKGL------FSRRKEDPALPTQV--PLQYNELKL 1305
            ..:|...|::|..||||:||.|: |..|||||.|      .|...::...|..|  .:.|..||.
  Fly  1236 RDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILYRALKE 1300

Human  1306 ALEKEKARCAELEEALQKTR--IELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQ 1368
            .|::|:...:.|:|.|.:..  ..|||.|:.||....:|.|       .::.::::|:.|||:.|
  Fly  1301 ELKREQKMNSLLKEQLAQLNGTATLRSPRKSAAVNGDSDAP-------KQRPVSIAALPRSPQKQ 1358

Human  1369 PSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGL---NMRATKCAVCLDTVHFGRQ 1430
            ...   |...:|:.:..:|.|:.::...|...|   |||.:.|   .:.|..|.||...|..|..
  Fly  1359 QQP---LKRTTSQVELKTTAEKPTKVTIENQAH---HRFELALQESKVDAVNCVVCEKAVVAGSP 1417

Human  1431 ASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVP 1495
            ..||.||:.:.|.||.:.:.:.||                        :.:|::
  Fly  1418 FWKCKECKDVTHRKCRSNVQSHCG------------------------STKPTA----------- 1447

Human  1496 RNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAK 1560
                                                        |..|
  Fly  1448 --------------------------------------------PSAD----------------- 1451

Human  1561 ADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESV-VAGGRVSREK------AEADA 1618
             |:..|..:.|                          ..|:|| ||||..|..:      ..:|.
  Fly  1452 -DLSSIQSVSS--------------------------LTLDSVDVAGGTTSGGEYIGSLVYSSDG 1489

Human  1619 ARDCVSYELLPAWVQKLLGNSLLKLEGDDRLDMNCTLPFSD-QVVLVGTEEGLYALNVLKNSLTH 1682
            |.|                      :....:::||....:: |::|:|...||||.::....|.|
  Fly  1490 AED----------------------QARKEIEVNCAFEVAEQQILLLGCNTGLYAYHLDSQRLVH 1532

Human  1683 VPGIGAVFQIYIIKDLEKLLMI--AGEERALCLVDVKKVK---QSLAQSHLPAQPDIS-----PN 1737
            :.|:.:|..:.|.|.|.|.:|:  .||:...|  |.::::   ||.:..|.|.....:     .|
  Fly  1533 ISGLESVSCMSICKRLAKAIMVGTVGEKLYQC--DYRQLESRCQSSSSCHKPVLETSAIELPFAN 1595

Human  1738 IFEAVKGCHLFGAGKIENGL--CICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYS 1800
            ...:.|...:..:.:.||.|  ...||..:::|||:|:..|..:...:.::|:.|.:.|.||.:|
  Fly  1596 RTPSEKWKLVLISDEAENALDSVAIAATSTRIVILKYDLKLHMFKPVRALDTATPVTSIFFTRHS 1660

Human  1801 ILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFG 1865
            .::.::||||||:..|..|||:|.:|.|:     .:::...|::.|:::    |:||||||.|:|
  Fly  1661 AIVSSDKFYEIDLDNYAAEEFVDLSDKSM-----ESTAKCQPLTAVRIS----RQEYLLCFAEYG 1716

Human  1866 VFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEI------------QARSSAGTP 1918
            ||||.:|.|||..||.|...|..|.||:|:||::|:.|::::.:            .|..::.:|
  Fly  1717 VFVDEFGCRSRPYDLNWVYAPTGFVYRDPFLFISHYQSVQIVRLHRSFSKEMASGDNASENSESP 1781

Human  1919 --ARAYLDIPNPRYLGPAI-SSGAIYL 1942
              .|.||    |.|:...: :||.:.|
  Fly  1782 ELQRVYL----PHYMSTLLANSGDVNL 1804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	160/350 (46%)
		CwlO1	442..>598	CDD:443091	32/166 (19%)
		SMC_prok_B	531..1343	CDD:274008	208/895 (23%)
		CRIK	1401..1456	CDD:410364	20/57 (35%)
		PH	1486..1605	CDD:459697	8/119 (7%)
		CNH	1650..1946	CDD:214481	98/321 (31%)
sti	NP_001261768.1	Protein Kinases, catalytic domain	111..452	CDD:473864	160/350 (46%)
		SMC_prok_B	481..1254	CDD:274008	193/883 (22%)
		C1	1389..1440	CDD:410341	17/50 (34%)
		CNH	1509..1779	CDD:459938	87/280 (31%)