Protein Alignment CIT and Pka-C1

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 342
• Identity: 111/342 - (32%)
• Similarity: 179/342 - (52%)
• Gaps: 31/342 - (9%)

Human    73 VSNFVRKYSDTIAELQELQP----SAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKAL 133
            |..|:.:..:...:.....|    :..|||....:|.|.|..|.:|:.|.|.|.||||::.|:.:
  Fly    18 VKEFLEQAKEEFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKV 82

Human   134 LAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLI 198
            :..:||.....|:.||.....|::..|:|.|:|.::||:|:||.|||::.|.| |...:..|...
  Fly    83 VKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHL-RKVGRFSEPHS 146

Human   199 QFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDY 263
            :||.|:::||...:|.:..::||:||||:|:|..|::|:.|||.|.::........    |||:|
  Fly   147 RFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLC----GTPEY 207

Human   264 MAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDP 328
            :|||::.     .|| |....|||::||:.|||..|..||......:.:..|::.:  ::||.
  Fly   208 LAPEIIL-----SKG-YNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPS-- 262

Human   329 KVSSDFLDLIQSLLCGQKERLKFEG--------LCCHPFFSKIDWNNI--RNSPPPFVPTLKSDD 383
            ...||..||:::||  |.:..|..|        :....:|:..||..|  :....||:|..|...
  Fly   263 HFGSDLKDLLRNLL--QVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPG 325

Human   384 DTSNFDEPEKNSWVSSS 400
            ||||||:.|:.:...||
  Fly   326 DTSNFDDYEEEALRISS 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	108/316 (34%)
		CwlO1	442..>598	CDD:443091
		SMC_prok_B	531..1343	CDD:274008
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	105/305 (34%)