Protein Alignment CIT and tip1

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_593613.1
• Gene: tip1 / 2543044
• PomBaseID: SPAC3C7.12
• Length: 461
• Species: Schizosaccharomyces pombe
• Alignment Length: 505
• Identity: 98/505 - (19%)
• Similarity: 178/505 - (35%)
• Gaps: 179/505 - (35%)

Human   699 SLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 763
            :|::.:.||..:....|.   .:.|.|.......:|||:            :.:|..|.:::.|.
pombe   104 NLQSSIPRLTNVSSSSNL---SMNTISSTALTPTEKILQ------------KRIEDLLYERQNHQ 153

Human   764 EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSE 828
            :        |:::.||..:.|::::....::..|           ::.:..:|...|:||
pombe   154 Q--------QLEEVLATVDQLQSLVTNFNDQQDE-----------VDELRERITLKEERI----- 194

Human   829 ANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKL-EAQNRKLEEQLEKISHQDHSDKNR 892
                               ::|.:|..|::|..:|....| |:.||.:|           :.:||
pombe   195 -------------------QQMRNEASQRRFEFKTTIECLEESSNRAIE-----------TYENR 229

Human   893 LLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 957
            :.|||.:|........|..|     |..||   |||:..|..::..:..:::.::|.
pombe   230 IAELEAQLEMYMSGKSEDDL-----LFSLQ---QERDYALNQVEILQERVDTLMKQK-------- 278

Human   958 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA 1022
                                    .||.|.    .|:|:.:...:..|.|.:|...|:   ..|:
pombe   279 ------------------------ANSSTA----NEKLSHMESSSPTLTNASFESPKR---GKGS 312

Human  1023 NDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDE------LLEK 1081
            ||               :.|...|   ::||:|..:....:|.|:|..|:||:||      .|||
pombe   313 ND---------------LPENHPQ---RRQTLEFYEIEIEVLREKVEKLQALSDEKDFYISKLEK 359

Human  1082 ERQWEAWRSVLGD--------EKSQFECRVRELQRMLDTEKQSRARADQRIT------ESRQVVE 1132
            .........|..|        ||.....|:.||:..::....:..|.::|::      |:.|.||
pombe   360 SLDRNDTTPVPSDEKLSNYAAEKENLVSRISELEHTIEQLTINNERDNERMSPAEFELETTQEVE 424

Human  1133 LAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ 1182
                                    |:.||..:|.|....:.|.|..|||:
pombe   425 ------------------------ENDSDSHDDEETWCEVCETNNHSLQE 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752
		CwlO1	442..>598	CDD:443091
		SMC_prok_B	531..1343	CDD:274008	98/505 (19%)
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
tip1	NP_593613.1	CAP_GLY	4..74	CDD:214997
		SMC_prok_B	<142..399	CDD:274008	73/375 (19%)