Protein Alignment CIT and pka1

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_595159.1
• Gene: pka1 / 2539781
• PomBaseID: SPBC106.10
• Length: 512
• Species: Schizosaccharomyces pombe
• Alignment Length: 339
• Identity: 114/339 - (33%)
• Similarity: 186/339 - (54%)
• Gaps: 45/339 - (13%)

Human    77 VRKYSDTIAELQELQ-----PS---------AKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKV 127
            :||.  .:::|.:||     |:         .:||.....:|.|.|..|.:|:.......||:||
pombe   169 IRKV--RVSQLLDLQRRRIRPADHTTKDRYGIQDFNFLQTLGTGSFGRVHLVQSNHNRLYYAIKV 231

Human   128 MKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQ 192
            ::||.::..:|:....:||.||||...|:|..|...|||..:|::||::..||:|.|||.:.. :
pombe   232 LEKKKIVDMKQIEHTCDERYILSRVQHPFITILWGTFQDAKNLFMVMDFAEGGELFSLLRKCH-R 295

Human   193 LDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLP 257
            ..|.:.:||.||:|||:..:|....|:||:||||:|:||.||:|:||||.|.:::::   |....
pombe   296 FPEKVAKFYAAEVILALDYLHHNQIVYRDLKPENLLLDRFGHLKIVDFGFAKRVSTS---NCCTL 357

Human   258 IGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFL 322
            .|||||:|||::::.      .|....||||:|::.:||:.|..||......:.:.||:..:  :
pombe   358 CGTPDYLAPEIISLK------PYNKAADWWSLGILIFEMLAGYPPFYSENPMKLYENILEGK--V 414

Human   323 KFPDDPKVSSDFLDLIQSLLCGQKE------RLKFEG---LCCHPFFSKIDWNNI--RNSPPPFV 376
            .:|.  ..|...:||:..||  |::      .|| :|   :..||:|..|.|:.|  |....|:|
pombe   415 NYPS--YFSPASIDLLSHLL--QRDITCRYGNLK-DGSMDIIMHPWFRDISWDKILTRKIEVPYV 474

Human   377 PTLKSD-DDTSNFD 389
            |.:::. .|:|.||
pombe   475 PPIQAGMGDSSQFD 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	108/307 (35%)
		CwlO1	442..>598	CDD:443091
		SMC_prok_B	531..1343	CDD:274008
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
pka1	NP_595159.1	STKc_PKA_like	199..490	CDD:270732	108/307 (35%)