Protein Alignment CIT and ppk33

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_588234.1
• Gene: ppk33 / 2539202
• PomBaseID: SPCC162.10
• Length: 338
• Species: Schizosaccharomyces pombe
• Alignment Length: 336
• Identity: 99/336 - (29%)
• Similarity: 157/336 - (46%)
• Gaps: 50/336 - (14%)

Human    71 KHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLA 135
            |.|.|....:.|..|...|   |...|::|:::|.|.::.|.||:.:.|...:|:|.:.||. ..
pombe     7 KSVKNDKENFEDPNATNFE---SVSQFKIRNVIGKGSWSTVFVVKHRQTKQRFALKCINKKK-HD 67

Human   136 QEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRY---EDQLDENL 197
            :.::.....|..:|.....|.:.:....|:|:..:|||.:...||||     ||   :.:.:|::
pombe    68 EHKIKKLRNEVLLLQSLNHPLLCKFYSEFEDETKIYLVTDLMLGGDL-----RYHISQRKFNESV 127

Human   198 IQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMN-------SNKMVNAK 255
            |:.::.||:.|:..:|..|.:|||:||:|||:|..||.||.||..|||::       ||..|..
pombe   128 IRIWMVELVSALIYIHSKGVLHRDVKPDNILLDEKGHCKLADFNVAAKVHTSSSPSKSNMTVGR- 191

Human   256 LPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPF--------------AEG 306
              :|||.|||||.|.      ......:.||||:|:..||.::...||              .:.
pombe   192 --VGTPVYMAPETLI------HAVSYKESDWWSLGITFYECLFQVRPFPNHLLINWIRASEEEKA 248

Human   307 TSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLL-CGQKERL--KFEGLCCHPFFSKIDWNNI 368
            :||...::.::..|..|.   ..:|.|....:.:.| ...|:||  ..:.|..||||..|....:
pombe   249 SSADRLSSALHISRDKKL---TTISKDARSAVMAFLEMDIKKRLGHSSKKLQTHPFFCSISLETV 310

Human   369 R--NSPPPFVP 377
            .  |..|.|.|
pombe   311 SKGNLTPIFRP 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	92/312 (29%)
		CwlO1	442..>598	CDD:443091
		SMC_prok_B	531..1343	CDD:274008
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
ppk33	NP_588234.1	Protein Kinases, catalytic domain	29..302	CDD:473864	85/290 (29%)