Protein Alignment CIT and citk-2

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_494921.1
• Gene: citk-2 / 173864
• WormBaseID: WBGene00019087
• Length: 1286
• Species: Caenorhabditis elegans
• Alignment Length: 1544
• Identity: 327/1544 - (21%)
• Similarity: 605/1544 - (39%)
• Gaps: 392/1544 - (25%)

Human   529 SQEDDK-----ALQLLHDIREQSRKLQE------------IKEQEYQAQVEEMRLM---MNQLEE 573
            |.||.|     |..::.|:|.:...|.|            |.||..:...:|.|:.   :|.||:
 Worm    43 SHEDLKKRVLDAENIIQDLRSERDALHETLVDKAGLNESVIIEQSKRVSTQETRIYRRDVNLLED 107

Human   574 DLVSARRRSDLYESELR--ESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEY----AKLEKINA 632
            ||..       ::|::|  :::.:..|.:::.  .|..:.:|:|..|....|.    ::|..:..
 Worm   108 DLKH-------HQSQIRILQNKCSTLEMEKQT--LQETIQRAQDDKKETETELESSRSRLHVLEK 163

Human   633 EQQLK-------IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKL 690
            |...|       .::|.:|.|:......|....|....:.|:..|.:|||.:|  |..|..||.|
 Worm   164 ELSAKANDIFMVTKDLHDKNEELTSFRMEYVTKLSEANREKKALEEKLEKYKN--DMKENDRKSL 226

Human   691 VEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVH 755
             |..:.:.:.:|.:..:..:......|        ..:::.|.||.||:|.|   |:||:.:|..
 Worm   227 -ELNKEQVTTQNVLSEVRQLSAHFEFL--------TPVRKNASKIRELDEYH---QLSAKVIEES 279

Human   756 LKQKEQHYEEKIKVLDNQIKKDLADK--------ETLENMMQR------HEEEA----HEKGKIL 802
            :..        :|:.:..:.|:|:||        |.||::.|.      ..|:|    ||:...|
 Worm   280 MND--------LKIKNETLTKELSDKTELVKMKNEELEDLRQTTTASLGDSEQATKYLHEENMKL 336

Human   803 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISE---LRQQKFYLETQ 864
            :.|||.|..             ||.||.:.........|...|.:::.:::   :|:.|..:|.:
 Worm   337 TRQKADIRC-------------ELLEARRKVEGFDKLKQELEKERDDALADVQKIREVKRNVERE 388

Human   865 AGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQ 926
            ...|.:...:.:||:|::       |.::...|.    :..:||..|.||.|   :|.::...|.
 Worm   389 LQSLTSLMAERDEQIEEL-------KTKMFSFEM----IKKDHESAKNELSRTQEKLDQMGKHLI 442

Human   927 ERESQLTALQAARAALESQLRQA--------------KTELEETTAEAEEEIQALTAHRDEIQRK 977
            ..:.|.:..::.:.:.|...|:|              :|.| |:..:.|:|::.|.|......:|
 Worm   443 MADQQCSTFKSLKESAEGSRRRAIEQCNEMVVRIRDLQTSL-ESQRKVEQEVEMLKAENSRQAKK 506

Human   978 FDALRNSC-TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIT 1041
            .:.::... .|..|..::|::|.|                 :..|..|        .||||..::
 Worm   507 IEFMKEEIQEVHLDYRQELSRLAE-----------------KTKGKED--------ADHLRLTLS 546

Human  1042 EREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVREL 1106
            :|:.:|.|.|:|::.:|.
 Worm   547 QRDSELRSAKKTIQEVKA----------------------------------------------- 564

Human  1107 QRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHA 1171
                |.:|.             |::.:.|::|:.:|  |::.::.:|..|::|           |
 Worm   565 ----DNQKV-------------QLMLVEVRQHQEKI--LEENVRLRKGMADAL-----------A 599

Human  1172 MLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDL 1236
            .:|...||.|...||    .:||..|.|..:.::|       :|.:.|||...:.    .|..:|
 Worm   600 KIEEYKRSWQNSQET----CERLERESATKEDKLD-------KLEEELQEKKQQI----AESKEL 649

Human  1237 EYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYN 1301
                    |.|.|.::.     ::|||     |.|:.    ::..|.|...|   :.|.|.::
 Worm   650 --------VTYLHSQID-----AKQTK-----QPKLG----RRSTLLSTVSE---MDTSVYMR-- 687

Human  1302 ELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPE 1366
                  |.|:.|.  |||..|.....|...|.:....|.:            |..|.:.||.:..
 Worm   688 ------EAEEVRA--LEEQRQALMSNLAEKRRQLVDSKKS------------QSTANTTIVTTTT 732

Human  1367 HQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRF----NVG-LNMRATKCAVCLDTVH 1426
            .:.|            |.|.:..|.|.| :..|.|:|||::    :|| |:|   ||::|...:.
 Worm   733 TEIS------------KSSQSASELSNR-QGTMRHDIPHKWKAFRHVGVLSM---KCSLCFVGIS 781

Human  1427 FGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGW 1491
            ...:|.||..|.|..|..|:..:..|||:|.:.||::.|.  ...::|.|:      |...:.||
 Worm   782 AFAKAKKCSHCDVHVHASCAPRVNNTCGMPLQCATYYREN--HTTVSSSGV------SEGRMNGW 838

Human  1492 MKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELA 1556
            ::|.|::..|.. |...:.:::.:::..|.|:..:. ::|....:| ..:..|...|.....:..
 Worm   839 LRVYRDDMTGST-WIASWAMMDLTRISFYTNDGADL-EKPFFSIDL-NKEQWVLRTGQEMPVDCD 900

Human  1557 NTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAARD 1621
            ::.:|:...::||         |.|.||:||||.|..:||...|::......:...|..:.|...
 Worm   901 DSMRANNVLMIKM---------PRRCLYILAPSQPSARRWAECLQTAQRKRMMLNSKESSIAEFT 956

Human  1622 CVSYELLPAWVQKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLY--ALNVLKNSLTHVP 1684
            |                 ||.|...:.|.:.......|. :|..|:.||:  :::..:|.: .:.
 Worm   957 C-----------------LLVLNSPNNLKIFKAYTIEDW-ILFATQTGLFFTSISQPRNPM-RIA 1002

Human  1685 GIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFG 1749
            |..:|..:.|:.:::.:.|:|.....|.::.:    .||..:....||.|.|.|....:..|:..
 Worm  1003 GPNSVTSLEIMAEIKCVAMVANSSGQLAMIPL----DSLILAMQSTQPSIRPEILPEFEHVHMIK 1063

Human  1750 AGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMK 1814
            ..:......:..:..:.:.:.:||.....:....:.:..||.|.|......|:...:.||.:.:.
 Worm  1064 YHQQNGQRFLLISDDTHLHVRKYNATRDIFSQYAKFDVPEPISFIESAPSGIIFACDTFYYVALD 1128

Human  1815 QYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDD 1879
            ..|       :.:..|..:.:.:.|.||:|...:|    :.|.||.:...|:||:.:|.:||.:.
 Worm  1129 HQT-------SSNVSARKLMSPNKNEFPISAQMIN----QNEVLLAYQNQGIFVNLHGEQSRNET 1182

Human  1880 LKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPA-RAYLDIPNPRYLGPAISSGAIYLA 1943
            ::|.::|:.|.|..|:|::.|.:|:|::||...|.....| ||..:..|...:|.......|.::
 Worm  1183 IEWEKMPMEFIYTSPFLYIVHDDSIEILEISETSDRTVLAERALFECVNAHVIGRQYEGVLISVS 1247

Human  1944 SSYQDKLRVICCKGNLVKESGTEHHR-----GPSTSRSSPNKRGPPTYN 1987
            |:                 ..||.||     |.....:...:||...||
 Worm  1248 SN-----------------DSTEVHRFSTATGQKQKNNVSKRRGASPYN 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752
		CwlO1	442..>598	CDD:443091	21/90 (23%)
		SMC_prok_B	531..1343	CDD:274008	180/883 (20%)
		CRIK	1401..1456	CDD:410364	21/59 (36%)
		PH	1486..1605	CDD:459697	27/118 (23%)
		CNH	1650..1946	CDD:214481	64/298 (21%)
citk-2	NP_494921.1	SMC_prok_B	49..>717	CDD:274008	176/875 (20%)
		C1	754..811	CDD:412127	21/59 (36%)
		PH	835..940	CDD:459697	27/116 (23%)
		CNH	965..1248	CDD:214481	64/299 (21%)