DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHEK1 and chk1

DIOPT Version :9

Sequence 1:	XP_011540862.1	Gene:	CHEK1 / 1111	HGNCID:	1925	Length:	492	Species:	Homo sapiens
Sequence 2:	NP_001342786.1	Gene:	chk1 / 2539087	PomBaseID:	SPCC1259.13	Length:	496	Species:	Schizosaccharomyces pombe

Alignment Length:	436	Identity:	119/436 - (27%)
Similarity:	192/436 - (44%)	Gaps:	108/436 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   106 WEKVPME-----------KPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN 159
            |..|.:|           :||:|:.|..||.:|.|||.|:.::|..|:.|||:||||:|||...|
pombe    86 WRWVVLEFAQGGDLFDKIEPDVGIDEDVAQFYFAQLMEGISFMHSKGVAHRDLKPENILLDYNGN 150

Human   160 LKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW 224
            |||||||.|::|.|..:.||||...|:.||.|||:  .:::....||||||||:|.|:|.|..||
pombe   151 LKISDFGFASLFSYKGKSRLLNSPVGSPPYAAPEI--TQQYDGSKVDVWSCGIILFALLLGNTPW 213

Human   225 DQPSDSCQEYSDWK---EKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNK--- 283
            |:...:..:|..:|   |:.:| :||..:.....:::..:|..:|..|.::..:.:..|...
pombe   214 DEAISNTGDYLLYKKQCERPSY-HPWNLLSPGAYSIITGMLRSDPFKRYSVKHVVQHPWLTSSTP 277

Human   284 --------------------PLKKGAKRPRVTSGGVSESPSGFS-------KHIQSNLDFSPVNS 321
                                .|:....:||:.|...|::.||||       |:.|..||...|..
pombe   278 FRTKNGNCADPVALASRLMLKLRIDLDKPRLASSRASQNDSGFSMTQPAFKKNDQKELDRVEVYG 342

Human   322 ASSE-----ENVKYSS-SQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPG 380
            |.|:     :|:..:. .:.:|  .||.:..:..:|.:|.:........||.
pombe   343 ALSQPVQLNKNIDVTEILEKDP--SLSQFCENEGFIKRLAKKAKNFYEICPP------------- 392

Human   381 SSQNPWQRLVKRMTRFFTKLD----ADKSYQCLK-------------ETCEKLGYQWKKSCMNQV 428
                      :|:|||:::..    .|..|..|:             :|...:....|:.|:.|.
pombe   393 ----------ERLTRFYSRASRETIIDHLYDSLRLLAISVTMKYVRNQTILYVNLHDKRKCLLQG 447

Human   429 TISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKI 474
            .|..|:..:|        ||     |::|....||.||:::.|..:
pombe   448 VIELTNLGHN--------LE-----LINFIKRNGDPLEWRKFFKNV 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHEK1	XP_011540862.1	PKc_like	<114..281	CDD:304357	68/169 (40%)
CHEK1	XP_011540862.1	S_TKc	<117..280	CDD:214567	66/165 (40%)
chk1	NP_001342786.1	STKc_Chk1	8..272	CDD:270971	71/188 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	190	1.000	Domainoid score	I844
eggNOG	1	0.900	-	-		E1_KOG0590
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H975
Inparanoid	1	1.050	200	1.000	Inparanoid score	I1164
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001125
OrthoInspector	1	1.000	-	-		oto147259
orthoMCL	1	0.900	-	-		OOG6_104812
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R198
SonicParanoid	1	1.000	-	-		X2646
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.790