DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRDM5 and CG2889

DIOPT Version :9

Sequence 1:	NP_001366033.1	Gene:	PRDM5 / 11107	HGNCID:	9349	Length:	641	Species:	Homo sapiens
Sequence 2:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	99/407 - (24%)
Similarity:	151/407 - (37%)	Gaps:	82/407 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   125 DSDMEAEEEEQQIMTVIKEGEVENSRRQSTAGRKDRLGCKEDYACPQCESS--FTSEDILAEHLQ 187
            |.....|.:|.::..|::......||.|.....:..:......:|..||.|  :.||  |..|..
  Fly   232 DQRTTTESQESELQAVLERKPKGCSRAQLAKSYEKAIASYMSASCDLCEFSAPYLSE--LKTHFL 294

Human   188 TLHQKPTEEKEFKCKNCGKKFPVKQALQRHVLQCTAKSSLKESSRSFQCSVCNSSFSSASSFEQH 252
            .:||     :|:..|.|||.|.....|..|:.:       ..:.:.|.|::|.
  Fly   295 EVHQ-----REYYIKCCGKVFTRASKLMDHIRK-------HINPKLFTCTICK------------ 335

Human   253 QETCRGDARFVCKADSCGKRLKSKDALKRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIH 317
                              |.|.|:|.|..|.|.||             ||.......|:
  Fly   336 ------------------KSLNSQDYLATHIETVH-------------NKVAQIGKVLK------ 363

Human   318 EIFDCQECMKKFISANQLKRHMITHSDMRLSPLIFLIEKRPYNCEICNKSFKRLDQVGAH-KVIH 381
              |.|.:|.:.|.|..::..|:..|...:|.          :.||||.|||..:.::..| :.||
  Fly   364 --FPCPKCERTFSSERRMANHLAKHDTDQLE----------HTCEICCKSFANVHRLRRHIQSIH 416

Human   382 SEDKPYKCKLCGKGFAHRNVYKNHKKTHS--EERPFQCEECKALFRTPFSLQRHLLIHNSERTFK 444
            .:...:.|.:|||.|..:..::.|...|.  .....:|..|:...:...||:.|...|:|..|.
  Fly   417 EDLHRHVCDICGKKFKFKPSFERHLLEHQGVVAPAVECPICRVWLKNEHSLRLHRFTHDSTDTV- 480

Human   445 CHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKF 509
            |.||..|...:..|..||:..|:.....:|..|.|.|.....|..|...|||.:...||:|.::.
  Fly   481 CPHCGKTCTSRTALRGHVKYAHKLTTNLQCTFCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKEC 545

Human   510 ASSGTLRVHIRS-HTGE 525
            .|...:.|||:. |..|
  Fly   546 RSRSNMYVHIKQRHADE 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRDM5	NP_001366033.1	PR-SET_PRDM5	2..128	CDD:380967	1/2 (50%)
		COG5048	<145..338	CDD:227381	41/194 (21%)
		C2H2 Zn finger	169..190	CDD:275368	8/22 (36%)
		C2H2 Zn finger	201..221	CDD:275368	7/19 (37%)
		C2H2 Zn finger	236..256	CDD:275368	2/19 (11%)
		COG5048	262..631	CDD:227381	71/268 (26%)
		C2H2 Zn finger	264..287	CDD:275368	7/22 (32%)
		C2H2 Zn finger	297..317	CDD:275368	3/19 (16%)
		C2H2 Zn finger	322..342	CDD:275368	5/19 (26%)
		C2H2 Zn finger	361..381	CDD:275368	8/20 (40%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
		C2H2 Zn finger	445..462	CDD:275368	5/16 (31%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		C2H2 Zn finger	502..522	CDD:275368	7/20 (35%)
		C2H2 Zn finger	530..550	CDD:275368
		C2H2 Zn finger	558..578	CDD:275368
		C2H2 Zn finger	586..606	CDD:275368
		C2H2 Zn finger	615..636	CDD:275368
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071
		C2H2 Zn finger	276..297	CDD:275368	8/22 (36%)
		C2H2 Zn finger	306..323	CDD:275368	6/23 (26%)
		C2H2 Zn finger	331..352	CDD:275368	9/50 (18%)
		C2H2 Zn finger	366..386	CDD:275368	5/19 (26%)
		C2H2 Zn finger	395..416	CDD:275368	8/20 (40%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..502	CDD:275368	7/20 (35%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	538..556	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000