DRSC/TRiP Functional Genomics Resources

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Protein Alignment KATNA1 and Rpt6R

DIOPT Version :10

Sequence 1:NP_008975.1 Gene:KATNA1 / 11104 HGNCID:6216 Length:491 Species:Homo sapiens
Sequence 2:NP_651811.1 Gene:Rpt6R / 43635 FlyBaseID:FBgn0039788 Length:399 Species:Drosophila melanogaster


Alignment Length:314 Identity:120/314 - (38%)
Similarity:174/314 - (55%) Gaps:47/314 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   180 NKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPW 242
            ||.|      .||..:   ::.:.|:..::.:..|.:..:.:||.:.||:..||.|.  ||.:| 
  Fly   123 NKVD------PLVSLM---LVEKVPDSTYEMVGGLDKQIQEIKEVIELPVKHPELFDALGITQP- 177

Human   243 KGVLMVGPPGTGKTLLAKAVA--TECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATI 305
            ||||:.|||||||||||:|||  |||  ||..||.|.|..|:.||..::||.||.|||.::|:.|
  Fly   178 KGVLLYGPPGTGKTLLARAVAHHTEC--TFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSII 240

Human   306 FIDEIDSICSRR---GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDE 367
            |:||||||.|.|   ||.:..  .:|...|||.|:||...|       |.:.|:.|||....:|:
  Fly   241 FMDEIDSIGSARLETGTGDSE--VQRTMLELLNQLDGFEAT-------KNIKVIMATNRIDVLDQ 296

Human   368 ALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASL 430
            ||.|  |::::|..|.|:.:.|.::|:|..|::.|...::|..|||.|.|.|||::..||.:|.:
  Fly   297 ALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAEEMPGASGAEVKGVCTEAGM 361

Human   431 MAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKW 484
            .|:|.|               .:|:  |.||||||:.||....|..::...:.|
  Fly   362 YALRER---------------RVHV--TQEDFEMAVSKVMMKDSEKNMSIRKFW 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KATNA1NP_008975.1 Interaction with microtubules 1..185 3/4 (75%)
Interaction with dynein and NDEL1. /evidence=ECO:0000250 1..75
Interaction with KATNB1. /evidence=ECO:0000269|PubMed:10751153 1..29
Kp60-NTD 5..72 CDD:439297
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..185 3/4 (75%)
RecA-like_KTNA1 210..379 CDD:410930 80/177 (45%)
AAA_lid_3 403..447 CDD:465537 15/43 (35%)
Vps4_C <451..489 CDD:462762 12/34 (35%)
Rpt6RNP_651811.1 PRK03992 21..395 CDD:179699 119/309 (39%)
Blue background indicates that the domain is not in the aligned region.

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