Protein Alignment KATNA1 and CG4701

DIOPT Version :10

• Sequence 1: NP_008975.1
• Gene: KATNA1 / 11104
• HGNCID: 6216
• Length: 491
• Species: Homo sapiens
• Sequence 2: NP_609721.1
• Gene: CG4701 / 34858
• FlyBaseID: FBgn0028868
• Length: 384
• Species: Drosophila melanogaster
• Alignment Length: 343
• Identity: 115/343 - (33%)
• Similarity: 184/343 - (53%)
• Gaps: 35/343 - (10%)

Human   148 RGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIA 212
            ||||....|::     ..:.|.|.....:    ||.:..:::..:......:..::.::.|.|||
  Fly    43 RGKAKYVAEEQ-----LRKLNSSAIGAAK----KFRARDFNEHEMMIASHLVTPEDIDISWSDIA 98

Human   213 DLVEAKKLLKEAVVLPMWMPEFF---KGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVS 274
            .|....:.|:|.||||:...:.|   |..|.| ||||:.||||.||||:|||:|.:....|.|:.
  Fly    99 GLDGTIQELRETVVLPVRHRKLFSRSKLWRAP-KGVLLHGPPGCGKTLIAKAIAKDAGMRFINLD 162

Human   275 SSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDG 339
            ...||.|:.|||:||...:|.:|:...|..||||||:|....|| |.:|||:..:|.:.::|.||
  Fly   163 VGVLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRG-SNDHEATAMIKTQFMLQWDG 226

Human   340 VGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDV 404
            :     ..:.:..|:||.|||.|.|:|:|:.||:..:.:|.:|....|.|:|::.|:..:|:..|
  Fly   227 L-----MSNTNICVLVLGATNRPQDLDKAILRRMPAQFHIGVPRDCQRREILQLILQTEQLSPSV 286

Human   405 DLASIAENMEGYSGADITNVCRDASLMAMRR--RIEGLTPEEI-----------RNLSKEEM-HM 455
            :|..:|....|:||:|:..:||.||:..||:  |.:..|.|||           ::.:.:|. |:
  Fly   287 NLKELARLTIGFSGSDLRELCRHASMYRMRQFMREKLNTGEEIGKDKIEWDFEVKDQALQEWEHL 351

Human   456 PTTMEDF--EMALKKVSK 471
            ...|||.  .:::.|.||
  Fly   352 EIQMEDLLKSLSVMKASK 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNA1	NP_008975.1	Interaction with microtubules	1..185		9/36 (25%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75
		Interaction with KATNB1. /evidence=ECO:0000269|PubMed:10751153	1..29
		Kp60-NTD	5..72	CDD:439297
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..185		9/36 (25%)
		RecA-like_KTNA1	210..379	CDD:410930	72/171 (42%)
		AAA_lid_3	403..447	CDD:465537	18/56 (32%)
		Vps4_C	<451..489	CDD:462762	8/24 (33%)
CG4701	NP_609721.1	CDC48	<21..368	CDD:273521	113/340 (33%)
		RecA-like_ATAD1	96..261	CDD:410928	72/171 (42%)