Protein Alignment KATNA1 and Fign

DIOPT Version :10

• Sequence 1: NP_008975.1
• Gene: KATNA1 / 11104
• HGNCID: 6216
• Length: 491
• Species: Homo sapiens
• Sequence 2: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 431
• Identity: 149/431 - (34%)
• Similarity: 240/431 - (55%)
• Gaps: 45/431 - (10%)

Human    86 AQHDLPASEGEVWSMPVPVERRPSPGP------------RKRQSSQYSDPKS----HGNRPSTTV 134
            |..||.|...|| |...||::.....|            :|..:.|||...|    .|.|.:...
  Fly    98 ASSDLQAPALEV-SSTYPVQQAVKSRPEGQFPESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQ 161

Human   135 RV-------HRSSAQNVHNDRGKAVRCREKKEQNKGREEKN-KSPAAVTEPETNKFDST------ 185
            .:       :|.:...|.......:..|:|....|.....| .||.|..:..|:...|:
  Fly   162 LIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALA 226

Human   186 GYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGP 250
            ..|..:|:.:..:.:.....|.|:|||.|..||....||:::|:..|:.|.|:|.|.:|||:.||
  Fly   227 HLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGP 291

Human   251 PGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICS 315
            |||||||:||::|::.|..||:::.|:||||:.|::||||:.||.:|..:.||.|||||:||:.|
  Fly   292 PGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLS 356

Human   316 RRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIP 380
            :| ::.|:|::.|:|.|.|:.:||.....|     ..|:|:.|||.|.::|||:|||..:|:|:|
  Fly   357 KR-SANENESTLRLKNEFLIHLDGAASNEE-----IRVLVIGATNRPQELDEAVRRRFVRRLYVP 415

Human   381 LPSAKGREELLRISLRELELADDV-DLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEE 444
            ||:.:.|::::...:.:::...|| .:..:||..:||||||:..:||.||:..:|    .|||::
  Fly   416 LPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLR----SLTPDQ 476

Human   445 IRNLSKEEMHMP-TTMEDFEMALKKVSKSVSAADIERYEKW 484
            :..:  |...:| .||:||:.||:.:|||||:.|.:::|.|
  Fly   477 MEVI--ETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEAW 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNA1	NP_008975.1	Interaction with microtubules	1..185		27/122 (22%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75
		Interaction with KATNB1. /evidence=ECO:0000269|PubMed:10751153	1..29
		Kp60-NTD	5..72	CDD:439297
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..185		26/121 (21%)
		RecA-like_KTNA1	210..379	CDD:410930	78/168 (46%)
		AAA_lid_3	403..447	CDD:465537	18/44 (41%)
		Vps4_C	<451..489	CDD:462762	16/35 (46%)
Fign	NP_608763.2	PH-like	<4..50	CDD:473070
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	82/190 (43%)
		AAA_lid_3	444..495	CDD:465537	22/56 (39%)
		Vps4_C	<480..520	CDD:462762	16/38 (42%)