Protein Alignment KATNA1 and Rpt6

DIOPT Version :10

• Sequence 1: NP_008975.1
• Gene: KATNA1 / 11104
• HGNCID: 6216
• Length: 491
• Species: Homo sapiens
• Sequence 2: NP_608447.1
• Gene: Rpt6 / 33105
• FlyBaseID: FBgn0020369
• Length: 405
• Species: Drosophila melanogaster
• Alignment Length: 393
• Identity: 135/393 - (34%)
• Similarity: 200/393 - (50%)
• Gaps: 73/393 - (18%)

Human   128 NRPSTTVRVHRSSAQNVHNDR---GKAVRCREKK--------------EQNKGREEKNKSP---- 171
            |..:..||:.|...|.:....   |:.|:..:||              :.:|..:..:.:|
  Fly    49 NELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDVTPNCRV 113

Human   172 AAVTEPET------NKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMW 230
            |...|..|      ||.|      .||..:   ::.:.|:..::.:..|.:..|.:||.:.||:.
  Fly   114 ALRNESYTLHKILPNKVD------PLVSLM---MVEKVPDSTYEMVGGLDKQIKEIKEVIELPVK 169

Human   231 MPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVA--TECKTTFFNVSSSTLTSKYRGESEKLVR 291
            .||.|.  ||.:| ||||:.|||||||||||:|||  |||  ||..||.|.|..|:.||..::||
  Fly   170 HPELFDALGIAQP-KGVLLYGPPGTGKTLLARAVAHHTEC--TFIRVSGSELVQKFIGEGSRMVR 231

Human   292 LLFEMARFYSPATIFIDEIDSICSRR---GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMV 353
            .||.|||.::|:.||:||||||.|.|   |:..:.|. :|...|||.|:||...|       |.:
  Fly   232 ELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEV-QRTMLELLNQLDGFEAT-------KNI 288

Human   354 MVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGY 416
            .|:.|||....:|.||.|  |::::|..|.|:.:.|.::|:|..|::.|...::|..|||.|.|.
  Fly   289 KVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGA 353

Human   417 SGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERY 481
            |||::..||.:|.:.|:|.|               .:|:  |.||||||:.||.:..|..::...
  Fly   354 SGAEVKGVCTEAGMYALRER---------------RVHV--TQEDFEMAVAKVMQKDSEKNMSIK 401

Human   482 EKW 484
            :.|
  Fly   402 KLW 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNA1	NP_008975.1	Interaction with microtubules	1..185		17/83 (20%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75
		Interaction with KATNB1. /evidence=ECO:0000269|PubMed:10751153	1..29
		Kp60-NTD	5..72	CDD:439297
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..185		17/83 (20%)
		RecA-like_KTNA1	210..379	CDD:410930	81/177 (46%)
		AAA_lid_3	403..447	CDD:465537	15/43 (35%)
		Vps4_C	<451..489	CDD:462762	12/34 (35%)
Rpt6	NP_608447.1	PRK03992	23..399	CDD:179699	134/386 (35%)