Protein Alignment KATNA1 and Vps4

DIOPT Version :10

• Sequence 1: NP_008975.1
• Gene: KATNA1 / 11104
• HGNCID: 6216
• Length: 491
• Species: Homo sapiens
• Sequence 2: NP_573258.1
• Gene: Vps4 / 32777
• FlyBaseID: FBgn0283469
• Length: 442
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 161/383 - (42%)
• Similarity: 221/383 - (57%)
• Gaps: 49/383 - (12%)

Human   147 DRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYD------KDLVEALERDIISQNPN 205
            ||.:.::...||.:.|..:|..:|.|  .:.:..|.||...|      |.|...||..|:.:.|.
  Fly    66 DRAEKLKEYLKKGKKKPIKEGGESSA--KDDKDKKSDSDDEDGDDPEKKKLQSKLEDAIVIEKPK 128

Human   206 VRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATEC-KTT 269
            |:|.|:|.|..||:.|||||:||:..|:.|.|.|.||||:|:.|||||||:.||||||||. ::|
  Fly   129 VQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRST 193

Human   270 FFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELL 334
            ||:||||.|.||:.|||||||:.|||:||.:.|:.||||||||:||.| :..|:::.||:|.|.|
  Fly   194 FFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSAR-SDNENDSVRRIKTEFL 257

Human   335 VQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISL-REL 398
            |||.|||..::.      ::||.|||.||.:|.|:|||.|||||||||.|..|..:.:|.| ...
  Fly   258 VQMQGVGNDTDG------ILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTT 316

Human   399 ELADDVDLASIAENMEGYSGADITNVCRDASLMAMR--------RRIEGLTP---EEIRN----- 447
            .:..:.||..:|...||||||||:.|.|||.:..:|        :|:.|.:|   |||.|
  Fly   317 HVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVNDLLVP 381

Human   448 ----------------LSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFG 489
                            .|.:....|.||.|...:|.:...:|:..|:::..|:..:||
  Fly   382 CSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFG 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNA1	NP_008975.1	Interaction with microtubules	1..185		10/37 (27%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75
		Interaction with KATNB1. /evidence=ECO:0000269|PubMed:10751153	1..29
		Kp60-NTD	5..72	CDD:439297
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..185		10/37 (27%)
		RecA-like_KTNA1	210..379	CDD:410930	98/169 (58%)
		AAA_lid_3	403..447	CDD:465537	22/54 (41%)
		Vps4_C	<451..489	CDD:462762	8/37 (22%)
Vps4	NP_573258.1	MIT_VPS4	6..69	CDD:239141	2/2 (100%)
		RecA-like_VPS4	126..296	CDD:410929	101/176 (57%)
		AAA_lid_3	323..361	CDD:465537	16/37 (43%)
		Vps4_C	379..439	CDD:462762	9/59 (15%)