Protein Alignment ATE1 and Ate1

DIOPT Version :10

• Sequence 1: NP_001426290.1
• Gene: ATE1 / 11101
• HGNCID: 782
• Length: 578
• Species: Homo sapiens
• Sequence 2: NP_001261101.1
• Gene: Ate1 / 37288
• FlyBaseID: FBgn0025720
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 566
• Identity: 198/566 - (34%)
• Similarity: 277/566 - (48%)
• Gaps: 110/566 - (19%)

Human    25 NQQDANGLCDMITVLKGRRPGSTPNRDSGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCC 89
            :||...|.|          .|:..:...||.|:.:..:||||||||||||.|.|.||....:|||
  Fly    11 SQQSKCGYC----------AGANCSLSHGMHAYQLDCRDYQDLIDRGWRRCGYYCYKLRNQETCC 65

Human    90 PQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQ 154
            |.|||:|..|:|:.|||:|::|:::.:||..|:     .|.:|.....|.....|:|::
  Fly    66 PCYTIKCNGLEFKLSKSNKRILRRINRFLRDGK-----RESKPEAGDGDGEADADYAIV------ 119

Human   155 CDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKG----- 214
                     ..|...||.:....::...::..:..........:|:.......|..|..|
  Fly   120 ---------APEVTASEPQPQLPDKSPPVINVEQVASLATAQRKPTKQATAAAVEAPTLGSNKSS 175

Human   215 -------ADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLE 272
                   |.:|..||:|||::|.:|:..||          |..|.....||       .|.|:|.
  Fly   176 LLSSSAAAPISNKPCKKAKQMRLDRRLAKL----------GDSASYSTKSL-------TQEKTLR 223

Human   273 DLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQVRLVPV 337
            |.: .:..|...|:|::.:|.||
  Fly   224 DFL-NTDSETNKHRLKIVLVASS------------------------------------------ 245

Human   338 SFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQ 402
               |.| ::......:||.|||:.:|.|.|.........|||..|||:.|.|.:||:.|||||||
  Fly   246 ---DTE-RTCADAVIALYRKYQITVHNDNPARLTLASMQRFLVKSPLKNEKPWDGPEMGYGSFHQ 306

Human   403 QYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMG 467
            |||||.|:||||||||||.||||||.:|||||||||||.|.:||||...:.|.||...|.|||||
  Fly   307 QYWLDDKLIAVGVIDILPGCVSSVYFFYDPDYSFLSLGTYGSLREIELVQSLAEKVPSLKYYYMG 371

Human   468 FYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCL-PSLENSKYCRFNQDPEA--VDEDRSTEPD 529
            |||||||||:|||:..||.|||||||.|:|:...: ..|:..||.|.|:||.|  |:|......|
  Fly   372 FYIHSCPKMRYKGKLSPSYLLCPETYEWLPLTDVIRAKLDEHKYQRLNEDPAARDVNEFLMEHLD 436

Human   530 RLQ-VFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERML 574
            .:: :...|....|..:::.:...|::..:::|:.|||::|:.|||
  Fly   437 EVKLLLGGRTRTDYKHFRQLRGTVSDDDIIIEYSKLVGKECARRML 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATE1	NP_001426290.1	None
Ate1	NP_001261101.1	ATE_N	14..85	CDD:461281	35/80 (44%)
		ATE_C	256..393	CDD:461282	87/136 (64%)