Protein Alignment HNRNPUL1 and Kpc1

DIOPT Version :10

• Sequence 1: NP_001426097.1
• Gene: HNRNPUL1 / 11100
• HGNCID: 17011
• Length: 866
• Species: Homo sapiens
• Sequence 2: NP_650425.1
• Gene: Kpc1 / 41826
• FlyBaseID: FBgn0038296
• Length: 1332
• Species: Drosophila melanogaster
• Alignment Length: 427
• Identity: 93/427 - (21%)
• Similarity: 169/427 - (39%)
• Gaps: 117/427 - (27%)

Human   116 IKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFL----PPEASQLKPDRQ---------- 166
            :|..||..:|    :::....| .::..:: :||..|.:    |.:.:.|...:|
  Fly     8 VKVFNEDIFE----QVDHDNLY-SDLDDDL-EGANCSTVPDPRPAKLADLSVTKQMLIVRTWLDD 66

Human   167 QFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSG 231
            :||..:....|...|.|.| .|.|.|    |.....:.|:..|:            :|:.||.:
  Fly    67 KFQQIQTDSNEEIRRLYME-TESRIG----PDLTIFDVDYTTTV------------RVSSDRLA- 113

Human   232 YPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSC----S 292
              |..:|   .::..||:..|..||..:|:.::.:             .|::|||:.:||    :
  Fly   114 --LRSQG---SFNTVRANCCVYGGRWMYEIHLHTK-------------GVMQIGWASNSCQFNEN 160

Human   293 TQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVE-LSFTKNGKWMGIAF 356
            :.:|:...||||.|:.::..:...:.||||:...||||...|.    |.| :.:.:||:.||:||
  Fly   161 SGVGDTKSSYGYDGSKQQIWHISTKKYGDKWQIGDVIGVTIDV----DKEVIEYYRNGRSMGVAF 221

Human   357 RIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGT--------- 412
            ...::..|........|.....:|.|||.|  |:...:.||..:...|:.:..|..
  Fly   222 NKLEKGPGISFFAAISLGYTQGIEANFGNR--PFMYPVSGFQPLMARPILKLQRANLLMNYLVNL 284

Human   413 ------------VGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVM 465
                        :.|.:.|:..:       :..||.:.|  .|:...:|:    ||.|.|...:.
  Fly   285 AGIFSKYNAQSGMAPTNGADARV-------STKKTVYCI--FATLLIEKF----TNEIFDPYIIE 336

Human   466 GLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNY 502
                        |||:::.:...|    :|:.|:.:|
  Fly   337 ------------DVLLRKISSMTN----LASEKENSY 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPUL1	NP_001426097.1	Necessary for interaction with HRMT1L1	1..103
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..205		21/102 (21%)
		Necessary for interaction with BRD7 and transcriptional activation. /evidence=ECO:0000269|PubMed:12489984	456..594		10/47 (21%)
		5 X 3 AA repeats of R-G-G	612..658
		Necessary for transcription repression	612..658
Kpc1	NP_650425.1	SPRY_RNF123	122..249	CDD:293940	39/143 (27%)
		RING-HC_RNF123	1263..1306	CDD:438203