Protein Alignment HNRNPUL1 and CG30122

DIOPT Version :10

• Sequence 1: NP_001426097.1
• Gene: HNRNPUL1 / 11100
• HGNCID: 17011
• Length: 866
• Species: Homo sapiens
• Sequence 2: NP_001163196.1
• Gene: CG30122 / 37146
• FlyBaseID: FBgn0050122
• Length: 1272
• Species: Drosophila melanogaster
• Alignment Length: 1284
• Identity: 326/1284 - (25%)
• Similarity: 468/1284 - (36%)
• Gaps: 469/1284 - (36%)

Human     1 MDVRRL---KVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDE-------------RELD 49
            |||.:|   ||.:||.|||.|||||:|:||.|.|||:|.:|....|.|             |.:.
  Fly     1 MDVAKLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMS 65

Human    50 ADDEPGRPGHINEE-----VETEGGSELEGTAQPPPPGLQPHAEP-------------------- 89
            ....|.:...:..|     :|.|...|.:...||.|...||.|||
  Fly    66 RSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAAAVTEDT 130

Human    90 ------GGYSGPDG----------------HYAMDNITRQNQFYDTQVIKQENESGYERRPLEME 132
                  ...|.|:.                ..|:..:..||:..|..:.:..:.:..|:.|.:.|
  Fly   131 TVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEDHDAAPEEQEPTQTE 195

Human   133 QQQAYRPEMKT-----------EMKQGAPTSFLPPEASQ----LKPDRQQFQSRKRPYEENRGRG 182
            :....:|...|           :|......|..|..|.:    .||:.|..:.|||.:..::.|.
  Fly   196 EPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPERRKRSHSRSKSRS 260

Human   183 YFEHREDR-RG-----RSPQPPAE-----EDEDDFDDTLVAIDTYNCDLHFKV-ARDRSSGYPLT 235
            ....|..: ||     |..:..||     |||...::..|.:...:.|||.:: ....:|..|||
  Fly   261 RSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHLRIDPTTFASAKPLT 325

Human   236 IEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHV--VRIGWSLDSCSTQLGEE 298
            .|.::.:||||||:||||.|:||||::::||...::......:|||  .|:|:|:...|..|||.
  Fly   326 SEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHVRGFRVGFSMPKSSLLLGEA 390

Human   299 PFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEAL 363
            ..|:||..||:|:|.|.|.:||..:..:|||||:.|.| .....:::|.||:.:|:||..:|..|
  Fly   391 EHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLE-SEPCTINYTLNGEDLGVAFEFEKSIL 454

Human   364 GGQ-ALYPHVLVKNCAVEFNF-------------------------------------------- 383
            |.: ||:||::.|......||
  Fly   455 GEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLD 519

Human   384 -----------------------------------------------------GQRAEP------ 389
                                                                 .:.|:|
  Fly   520 EATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATE 584

Human   390 ----------------------------------------------------------------- 389
                                                                             
  Fly   585 ASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEK 649

Human   390 ----------------YCSVLP----------GFTFIQHLPLSERIRGTVGPKSKAECEILMMVG 428
                            |..|:|          |:..|..:|:.:.:.|.....|:.|||::::||
  Fly   650 AESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQRVGSRKECEVILLVG 714

Human   429 LPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQ 493
            ||.||||.||.||.|.|..|:|.::|.:|.:.||.:.|..|:..:.||||.:.:.....|..|..
  Fly   715 LPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEICLNSLAALED 779

Human   494 IAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDEEGK--DVPDH 556
            ||.:::||:||||||||.|||||||:.|..|:|.|:|..|::::|| |.|...:|:|.  .|.:.
  Fly   780 IAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELK-RRIAEKEEKGNAFTVKES 843

Human   557 AVLEMKANFTLPDVG-DFLDEVLFIELQREEADKLVRQYNEEGRKA------------------- 601
            .:..::||||||.:. .:.|::.:.||..:||...|::|||:|:||
  Fly   844 TINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGKKAIDAERSRDKRSRGSRDNYR 908

Human   602 ------------------GPPPEKRF-DNR---GGGGFRGRGGGGGFQRYEN------------- 631
                              |...|.|: |:|   ||||:....||||.:.|:|
  Fly   909 RDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQN 973

Human   632 ------------RGPPGGNRG--GFQNR----GGGSGGGGNYRGGFNRSGGGGYSQNRWGNNN-- 676
                        ||..||..|  |:.||    .|||||||...||    ||||..|..|..||
  Fly   974 WVQNSRRSGYDDRGYGGGGSGSRGYDNRNRGYAGGSGGGGGGGGG----GGGGGGQQNWMQNNRR 1034

Human   677 --------------RDNNNSNNR---GS--YNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARN 722
                          ||.:..|:|   ||  .||...|.                    ||.
  Fly  1035 SGYDDRGYGSSRDYRDRDRGNDRSRMGSNDRNRGSSQS--------------------SYR---- 1075

Human   723 PPGASTYNKNSNIPGSSANTSTPTVSSY--SPPQSFGFFPSTFQPSYSQPPYNQGGYSQGYTAPP 785
             .|..|:.:....|| ..:|...:...|  |..||.        |.|.......|||.| |....
  Fly  1076 -SGGGTHQQRDFRPG-HRDTKEDSRGGYERSAGQSL--------PKYGNNTAVGGGYDQ-YKQQG 1129

Human   786 PPPPPPPAYNYGSYGGYNPAPYTPPPPPTAQT-----------YPQP-----------SYNQYQ- 827
            ..|....|...|.:..|:........|...||           |.||           :|||.|
  Fly  1130 GAPGGGKASLSGKWSTYSQHHQQQQAPQHQQTGIWQTQQQSQQYQQPQQAAAGQQQYWAYNQMQT 1194

Human   828 -------------QYAQQWNQYYQNQGQWPPYYGNYDYGSYSGNTQGGT 863
                         |..|||..::|.|.|.       ..|:.:||..||:
  Fly  1195 GYGNQQAWQSADPQQQQQWMSWWQQQQQG-------SGGAAAGNASGGS 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPUL1	NP_001426097.1	Necessary for interaction with HRMT1L1	1..103		44/164 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..205		49/255 (19%)
		Necessary for interaction with BRD7 and transcriptional activation. /evidence=ECO:0000269|PubMed:12489984	456..594		55/140 (39%)
		5 X 3 AA repeats of R-G-G	612..658		26/79 (33%)
		Necessary for transcription repression	612..658		26/79 (33%)
CG30122	NP_001163196.1	SAP	6..40	CDD:460424	21/33 (64%)
		PLN03124	8..>168	CDD:215591	40/159 (25%)
		SPRY_hnRNP	300..480	CDD:293942	70/180 (39%)
		PTZ00121	<520..>677	CDD:173412	5/156 (3%)
		AAA_33	709..855	CDD:463952	64/146 (44%)
		SF-CC1	1036..>1108	CDD:273721	18/97 (19%)