DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ADCY5 and Gyc76C

DIOPT Version :9

Sequence 1:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens
Sequence 2:NP_001163473.1 Gene:Gyc76C / 8674026 FlyBaseID:FBgn0266136 Length:1525 Species:Drosophila melanogaster


Alignment Length:980 Identity:203/980 - (20%)
Similarity:358/980 - (36%) Gaps:247/980 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   403 SQRQAFQETRECIQ----ARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQ 463
            |:|:|.:..|...|    :..||.....|..|.||.|          |.....::.:.|.| .:|
  Fly   265 SEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVV----------ASTPPTKDYIQFTK-QVQ 318

Human   464 KHD-----NVSI--LFADIEGFTSLASQCTAQELVMTLNELFA-RFDKLAAENHCLRIKILGDCY 520
            |:.     |:.|  ||.: ..|:...|...|  .:....:|:| ..||:..|    ..::|.|  
  Fly   319 KYSSKPPFNLEIPRLFVE-SNFSKFISIYAA--YLYDSVKLYAWAVDKMLRE----ETRVLTD-- 374

Human   521 YCVSGLPEARADHAHCCVEMGMDMIEAISLVR---EVTGVNVNM-RVGIHSGRVHCGVLGLRKWQ 581
                       |........|..:|:.|...|   .:||..:.: :.|...|..........||.
  Fly   375 -----------DVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWN 428

Human   582 FDVWSNDVTLANHM------EAGGKAGRIHITKATLNYLNGDYEV--EPGCGGERNAYLKE--HS 636
            .   ||::....||      ..|.:.....:...::::.:|..:.  ||.||.......|:  |.
  Fly   429 N---SNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHY 490

Human   637 IETF------LILRCT--------QKRKEEKAMIAKMNRQRTNSI-GHNPPHWGAERPFYNHLGG 686
            ..|.      ::|.|:        :|.|.|..:...:.:...|.| |::               |
  Fly   491 TSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYS---------------G 540

Human   687 NQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF-REPDLE 750
            |::.....::.....:...::.:       ::|:      .|..|||...||...|.| |:.|:.
  Fly   541 NEIVSSPSKVSLMSAQSYGSRWT-------NQFV------TSTGRLRGAVVRIKELKFPRKRDIS 592

Human   751 KKYSKQV-------DDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSV 808
            ::..|::       .|...:             |:..::.|..|.:::.|.....|..::....:
  Fly   593 REIMKEMRLLRELRHDNINS-------------FIGASVEPTRILLVTDYCAKGSLYDIIENEDI 644

Human   809 IYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCN----SRDLLGCLAQEH 869
                         .|....:.|.::..:.|:..|....|....|:.:.|    ||.:|    |..
  Fly   645 -------------KLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWML----QVT 692

Human   870 NISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSV---------LLSLLACSVFL 925
            :....::..|     |.|.|:|:.|.:....|   ..||.....:         ..:::...:|.
  Fly   693 DFGLHELRQC-----AENESIGEHQHYRNQLW---RAPELLRNHIHGSQKGDVYAFAIIMYEIFS 749

Human   926 QISCIGKLVLMLAIELIYVLIVEVPGVTLF-DNADLLVTANAIDFF------------NNGTSQW 977
            :....|::.......:.||..:.:.|...| ...:.::.|.:...:            .....::
  Fly   750 RKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEF 814

Human   978 SLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVES--TARLD 1040
            |:..| |.::|..|.  ...:.:|..|...|                    :|..:|.  |.|..
  Fly   815 SVIRN-RLKKMRGGK--TKNIMDQMMEMMEK--------------------YANNLEDIVTERTR 856

Human  1041 FLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF 1105
            .|     .|||.:.|:       |||.:||:.||......:......|    :.|.:.|:.|..|
  Fly   857 LL-----CEEKMKTED-------LLHRMLPQSVAEKLTMGQGVEPVSY----DLVTIYFSDIVGF 905

Human  1106 SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGK 1170
            :    .:.|.:..::.:..||::...||.||   |...:.|::|||..||..|||.    .|.|.
  Fly   906 T----AMSAESTPLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDAYMVVSGLP----IKNGD 959

Human  1171 THIKALADFAMKLMDQMKY--INEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASR 1233
            .|...:|..|::|:..:|.  |........:::||::.|||||||:|...|:|.::|:|||.|||
  Fly   960 RHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASR 1024

Human  1234 MDSTGVPDRIQVTTDMYQVL--AANTYQLECRGVVKVKGKGEMMTYFLNGG-------------- 1282
            |:|.|...:|.::......|  ....|..|.||:|.:||||:::|::|.|.              
  Fly  1025 MESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMD 1089

Human  1283 --PPL 1285
              |||
  Fly  1090 MPPPL 1094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454 13/58 (22%)
Guanylate_cyc 460..633 CDD:306677 37/192 (19%)
DUF1053 668..760 CDD:399378 15/99 (15%)
Guanylate_cyc 1087..1281 CDD:306677 65/197 (33%)
Gyc76CNP_001163473.1 PBP1_Speract_GC_like 26..445 CDD:107365 46/213 (22%)
ANF_receptor 48..412 CDD:279440 38/177 (21%)
PK_GC-A_B 543..827 CDD:270944 49/335 (15%)
HNOBA <835..881 CDD:285003 19/77 (25%)
CYCc 860..1052 CDD:214485 65/213 (31%)
Guanylate_cyc 887..1074 CDD:278633 65/201 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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