DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ADCY5 and ACXA

DIOPT Version :9

Sequence 1:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens
Sequence 2:NP_620475.2 Gene:ACXA / 53432 FlyBaseID:FBgn0040510 Length:1112 Species:Drosophila melanogaster


Alignment Length:1173 Identity:305/1173 - (26%)
Similarity:518/1173 - (44%) Gaps:253/1173 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   226 LERLYQRYFFRLNQSSLTML--MAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLC 288
            ||..|.:|..||..||||:.  |.:|::|.|.::.:........: |:..:.....:||:..:| 
  Fly    42 LEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYI-YINAIFDLGSLILVTGLL- 104

Human   289 NRAAFHQD----HMGLACY--ALIAVVLAVQVVGLLLPQPRSASEGIW-----WTVFFIYTIYTL 342
             ...|.:|    |..:..:  .|.|.|:   |:|.:........:..|     :.||.:..||..
  Fly   105 -SINFFEDFVIRHRWVMTFTSTLSAYVV---VLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMF 165

Human   343 LPV-RMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCT-------NIVGVCTHYP 399
            ||: ..:||.|..:.:|..::...:...|.::..:.:.|..:.|.|..       |::|:.....
  Fly   166 LPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIM 230

Human   400 AEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK--QEDMMFHKI-- 460
            .:...|.:|.:..:.|...:..::..:|:..||.|:||..:|..::..|..|  |.|..|:.:  
  Fly   231 NDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGT 295

Human   461 --------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 517
                    .||.|::||||:||:..:|.|.:..|.::||..|::|:||||..|......|||.||
  Fly   296 SRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLG 360

Human   518 DCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQF 582
            ||||||:||.|:..|||...|.:|:.||..|..|.....:|:.||:|:|||.:..||:|..|.|:
  Fly   361 DCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQY 425

Human   583 DVWSNDVTLANHMEAGGKAGRIHITKATLNYLNG-DYEVEPGC-GGERNAYLKEHSIETFLILRC 645
            |:|..||.:|:.:||.|..|.:|::..||:.||. :|.:.||. ..:::..|::|.:.|:|:   
  Fly   426 DIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLL--- 487

Human   646 TQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNH----LGGNQVSKEMKR---------MG 697
                    ..|..::..:|.||....|:...:....|.    |..|.:|.||:.         ..
  Fly   488 --------TAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFK 544

Human   698 FEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRF- 761
            |:.|..:..:...|  ::|:..||                 .|.:.|::..:|..|..|.|..| 
  Fly   545 FQFPWSRRERNLKN--EKVERDLG-----------------IFCVAFKDKSVEWNYLHQPDYIFK 590

Human   762 -----GAYVACASLVF--------LFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIY--- 810
                 |..:.|. |::        :|...|.|.|:  :.|:|:|      ||.:..:..|.:   
  Fly   591 YSVALGWGIGCC-LIYIQSVNNSDIFYTGVVINII--AFFVLTF------LLFICWYKKVCWWHS 646

Human   811 -----------SCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITL-VFLAAFVNMFTCNSRDLLG 863
                       ||.      :..|..||..|         |.:.| |::...:..:...|..|:.
  Fly   647 GQNEHRSYGKLSCA------IFHLFEKIQHS---------FVLRLTVYMMIILCYYMVISLILMS 696

Human   864 CLAQEHNISASQVNACHVAESAV-NYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQI 927
            |...::.:.        :.||.: ||.:  :...|..||.       :|..:.|.|.....|.:|
  Fly   697 CEKDQYELD--------IIESKLYNYDM--DPFTCFHPWA-------YTNMMALILGMSYTFARI 744

Human   928 SCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGT 992
            ....|..:..|..:::||:|......:|:::   ||          ||.:...|           
  Fly   745 PFALKTFIGCAEAVVFVLVVCFQYAFIFEHS---VT----------TSPYLKAE----------- 785

Human   993 YFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL 1057
                      ..|:.:|.:.::|          :|...:|.|...::::...|....:::..:..
  Fly   786 ----------IAHSCRVCMMLIT----------MYAKERQSEFNTKMNYKLNLDLQNKQKSADVT 830

Human  1058 QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1122
            ......||:||||..|...:|:...:: ||||::...|:||||.:.||.   ::|.:       |
  Fly   831 NQSIIILLNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNFQ---MDLPS-------L 884

Human  1123 RLLNEIIADFDEIISE-DRFRQLEKIKTIGSTYMAASGLNDSTYDKV------GKTHIKA----- 1175
            |:||:||..||.::|. .::..:||||.:|.|||||.||:.|..:.:      |.|.:.:     
  Fly   885 RVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQV 949

Human  1176 -------------------LADFAMKLMDQMKYIN--------EHSFNNFQMKIGLNIGPVVAGV 1213
                               :|.||:.||..:...|        :.:.:..:::||::.|.::|||
  Fly   950 RSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGV 1014

Human  1214 IGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMT 1276
            :||.:|.||||||.||:||||:|||:...||||.:..|.|  ..:.:.|  ||:..|||:||:.|
  Fly  1015 VGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTL--EEFDVMCYYRGLTFVKGRGEIPT 1077

Human  1277 YFL 1279
            ||:
  Fly  1078 YFV 1080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454 57/254 (22%)
Guanylate_cyc 460..633 CDD:306677 73/184 (40%)
DUF1053 668..760 CDD:399378 19/104 (18%)
Guanylate_cyc 1087..1281 CDD:306677 82/234 (35%)
ACXANP_620475.2 AC_N <42..291 CDD:292831 57/254 (22%)
CYCc 262..464 CDD:214485 82/201 (41%)
Nucleotidyl_cyc_III 306..489 CDD:299850 76/193 (39%)
CYCc 831..1055 CDD:214485 80/236 (34%)
Nucleotidyl_cyc_III 859..1080 CDD:299850 81/232 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4862
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.860

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