Protein Alignment ADCY5 and ACXB

DIOPT Version :10

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Alignment Length: 1171
• Identity: 311/1171 - (26%)
• Similarity: 521/1171 - (44%)
• Gaps: 251/1171 - (21%)

Human   226 LERLYQRYFFRLNQSSLTMLMAVLVLV---C-LVMLAFHAARPPLQLPYLAVLAAAVGVILIMAV 286
            ||..|::|..||..|.||:...:.:.|   | |....|...:   :|.|...|.|.|.::.:..:
  Fly    36 LEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQK---KLIYYESLTAIVVLVAVPGI 97

Human   287 LCNR--AAFHQDHMGLACYALIA---VVLAVQVVGLLLPQPRSASEGIW-----WTVFFIYTIYT 341
            |...  .:|...|..:..::.|.   :|:.|.:..:|:...:..    |     :.||.:..||.
  Fly    98 LSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKYH----WPLNTLYDVFVLCMIYM 158

Human   342 LLPV-RMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSN-----VLIFSCT--NIVGVCTHY 398
            .||: .:|.|.|....:|.:::.:.:.....|...:.::|.:     |.||...  |::|:....
  Fly   159 FLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRI 223

Human   399 PAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADI--------------- 448
            ..:...|.:|.:..:.::..:..::..||:..||.|:||..:|..::..|
  Fly   224 MNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIV 288

Human   449 -NAKQ-EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 511
             ||:: |:.|    .||.|.:||||:||:..:|.|.:..|.::||..|::|:.|||..|:.....
  Fly   289 VNARRTENFM----AIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQ 349

Human   512 RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLG 576
            |||.||||||||:||.||..|||...|.:|:.||..|..||....::::||:|:|||.:..||:|
  Fly   350 RIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIG 414

Human   577 LRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEPGCG-GERNAYLKEHSIET 639
            ..|.|:|:|..||.:||.:||.||.|.:|::..||:.|| .:|.|.||.. .:.:..|::..:.|
  Fly   415 QAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTT 479

Human   640 FLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVS-------------K 691
            :|             :.|..:|....|:  :..|..||... |.||.::.|             :
  Fly   480 YL-------------LTAAPSRNSVRSV--DAVHSYAEIDI-NALGASRKSPILRPTLMSDELRE 528

Human   692 EMKRM---GFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY 753
            |.|:|   || :.:....::::| :::|:..||....|.....|...::.|       ||...||
  Fly   529 EFKKMPVGGF-NIRSPCCRDNSN-DEKVNHGLGMFCVAFKDSSLEWSYLHK-------PDFILKY 584

Human   754 S--------------KQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVV 804
            |              :.|:|:|...|.|     :.|..|..|.:...:|:..|...|
  Fly   585 SVLLAWGIGCCLIYIQIVNDKFTICVEC-----IVIDMVVFTFLTSLLFISWFKKVC-------- 636

Human   805 FVSVIYSCVKLFPSPLQTLSRKIVR--SKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQ 867
                .:.||:........:|.|:.:  .::..:.|...||.:..:|::   :...|..||.|...
  Fly   637 ----WWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASY---YLLISTILLNCDKN 694

Human   868 EHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGK 932
            ::.:........|       |.:..:.  |.:||       .||..:.|.:.....|.:|....|
  Fly   695 QYELDVINSKLYH-------YDIVTDN--CFNPW-------VFTDMISLIVGVSYTFARIPFALK 743

Human   933 LVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSG 997
            :::.....:.|::||                     ||     |:|..  ..|    :.|..|..
  Fly   744 MLITCCATVAYLVIV---------------------FF-----QYSFI--FEH----SATTTPFM 776

Human   998 VKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL-QATEEKEEMEELQAYN 1061
            ..|.:  |..:|.:.::|          :|...:|.|...:::|  |: |..:.|::..::.  |
  Fly   777 KAELA--HCLRVCMMLLT----------MYAKERQSEFNTKINF--KINQDLQGKQKAADIT--N 825

Human  1062 RR---LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 1123
            :.   ||.||||..|...:| ....|.||||::.:.|:||||.:.||.   ::|.:       ||
  Fly   826 KSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLINFQ---MDLPS-------LR 879

Human  1124 LLNEIIADFDEIISE-DRFRQLEKIKTIGSTYMAASGLNDSTYDKV---GKTHIK---------- 1174
            :||:||.:||.:::. ..:..:||||.:|.|||||.|| |.|..|.   .:||..
  Fly   880 VLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGL-DFTLAKSKFGSRTHASYSSELEQVLY 943

Human  1175 ----------------ALADFAMKLMDQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIG 1215
                            .:..||:.||..:...|        :.:.:..::.||::.|.::|||:|
  Fly   944 RKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVG 1008

Human  1216 ARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYF 1278
            |.:|.||||||.||:||||:|||:|..|.||.:...:|  ..:.:.|  ||:..|||:||:.|||
  Fly  1009 ASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANIL--EQFDIMCMYRGMTFVKGRGEIPTYF 1071

Human  1279 L 1279
            :
  Fly  1072 V 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	58/270 (21%)
		Guanylate_cyc	460..643	CDD:425528	79/184 (43%)
		Adcy_cons_dom	668..761	CDD:461877	26/122 (21%)
		Guanylate_cyc	1087..1281	CDD:425528	81/233 (35%)
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	113/374 (30%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	80/202 (40%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	80/231 (35%)