Protein Alignment ADCY5 and ACXE

DIOPT Version :9

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 1210
• Identity: 317/1210 - (26%)
• Similarity: 533/1210 - (44%)
• Gaps: 276/1210 - (22%)

Human   204 SLGACCLALLQIFRSK-----------KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLV----C 253
            |||.|     |:..||           |....:||..::.|..||.:|.|.....:.:.|    |
  Fly     4 SLGNC-----QLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHC 63

Human   254 LVMLAFHAARPPLQLPYLAVLAAAVGVILIMAV-LCNR-AAFHQDHM-GLACYALIAVVLAVQVV 315
            .::||....|..:.......:..|:.:||:::| .|:. .|.|..:| ..:.:|.:.:|.|....
  Fly    64 ALLLATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTE 128

Human   316 GLLLPQPRSASEGIWWTVFFIYTIYTLLPVR-MRAAVLSGVLLSALH-------LAIALRTNAQD 372
            .:......|...|.::..:.||.||..||:. :..|||..:|:|.|:       :|......|..
  Fly   129 SIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASA 193

Human   373 QFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLP 437
            .|.:..:..:::.:.|.|:||:......:...|.:|.:..:.|:.::..:....|:::||.|:||
  Fly   194 LFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILP 258

Human   438 RHVAMEMKADIN-----AKQE----DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMT 493
            ..:::.::.||.     |||.    ..|...:.||.|.:||||:||:..:|.|.:..|.:.||..
  Fly   259 PQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKV 323

Human   494 LNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVN 558
            |::|:.|||..|......|||.||||||||:||.:...|||:.||.:|:.||..|..||::.|::
  Fly   324 LHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLD 388

Human   559 VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEP 622
            :|||:|:|||.:..||:|..|.|||:|..|||:||.:|:.|..|.:||:.||||.|: ..:::|.
  Fly   389 INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIED 453

Human   623 GCGGER-NAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGG 686
            |....| :..||::.|.:::|.:......|:.                            :...|
  Fly   454 GPEEARDHPLLKKYRIRSYIIRQDLHMDDEDS----------------------------DEFLG 490

Human   687 NQVSKEMKRMGFEDPKDKNAQESANP---EDEVDEFLGRAIDARSIDRLRSEHVRKF-------- 740
            :..|..:..||.:.....:|.:|...   |:..:||....:.|.|..||..  :.:|
  Fly   491 DLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG--ICRFNTGKEVPA 553

Human   741 ------LLTFREPDLEKKYSKQVDDRF------GAYVACASLVFLFI---------CFVQITIVP 784
                  .|||.:|.||:.|.||.|..:      .|.|.| |||::.:         |||    :|
  Fly   554 HQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGC-SLVYIELMDTQMICSSCFV----LP 613

Human   785 HSIFMLSFYLTCSLLLTLVVFVSVI----------------YSCVKLFPSPLQTLSRKIVRSKMN 833
            .|:      .|...:|.|:.:....                :||. :|         :|....:|
  Fly   614 ASV------ATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCF-IF---------RIHDKILN 662

Human   834 STLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCG 898
            |..:.:    .::|...::.|......::.|..:|..::       ::.|...:|.  .|...|.
  Fly   663 SLPIRI----CIYLFLMISSFFVMCLIVMSCQREEFEMA-------YIEERLFHYE--QEAHICF 714

Human   899 SPWPNCNFPEYFTYSVLLSLLAC--SVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLL 961
            .||...|         :|||:.|  ..|..|..:.|..:.:...|.|:|::
  Fly   715 HPWVTTN---------MLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLI-------------- 756

Human   962 VTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLAL 1026
                   ||.        .:.:.|..:....||.|       |:|        ..::|.:..|.:
  Fly   757 -------FFQ--------FDFVFHHSVTTNPYFKS-------EYA--------HALLICITFLIM 791

Human  1027 YLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK---DVAAHFLARERRNDELY 1088
            ::..:|:|.|.:::|.|::...:|:............:|:||||.   ||..:.||:.    |||
  Fly   792 FVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKH----ELY 852

Human  1089 YQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDE-IISEDRFRQLEKIKTIGS 1152
            :::...|:||||.:.||     |::     :..||:||||||:||. ::....:..:||||.:|.
  Fly   853 FENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGC 907

Human  1153 TYMAASGL---------------------------------NDSTYDKVGKTHIKALADFAMKLM 1184
            |||||.||                                 ::...|:|    :..:..:|:.:|
  Fly   908 TYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEV----VFVMTSYALDMM 968

Human  1185 DQMKYINE--------HSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPD 1241
            ..:...||        .:..:..:.||::.|.|:||::||.:|.||||||.||:||||:|||:|.
  Fly   969 RTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPG 1033

Human  1242 RIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1279
            .|.||.:..::|  ..:.:.|  ||:..|||:|::.||.:
  Fly  1034 HIHVTEETSEIL--QQFGITCSYRGMTFVKGRGKIPTYLV 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	67/288 (23%)
		Guanylate_cyc	460..633	CDD:306677	78/174 (45%)
		DUF1053	668..760	CDD:399378	24/108 (22%)
		Guanylate_cyc	1087..1281	CDD:306677	76/237 (32%)
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	55/240 (23%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	77/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	76/235 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910