DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADCY5 and Gycbeta100B

DIOPT Version :9

Sequence 1:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens
Sequence 2:NP_524603.2 Gene:Gycbeta100B / 43682 FlyBaseID:FBgn0013973 Length:787 Species:Drosophila melanogaster


Alignment Length:816 Identity:199/816 - (24%)
Similarity:314/816 - (38%) Gaps:252/816 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   537 CVEMGMDMIEAISLVREVTGV-------NVNMRVGIHSGRVHCGVL--GLRKWQFDVWSNDVTLA 592
            |.:.|.|.|      .:|.|.       |::   .:|.   |.|.|  |:|...|.....|..|.
  Fly    78 CQDSGYDKI------LQVLGATPRDFLQNLD---ALHD---HLGTLYPGMRAPSFRCTEKDGELL 130

Human   593 NHMEAGGKAGRIH----ITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRK--- 650
            .|..: .:.|..|    |.||..:.|:|   ||               :|..::     |||   
  Fly   131 LHYYS-ERPGLEHIVIGIVKAVASKLHG---VE---------------VEIDIV-----KRKGEP 171

Human   651 ----EEKAMIAKMNRQ------RTNSIGHN----PPHWGAERPFYNHLG------------GNQV 689
                |::..||:.|:|      .|.:.|..    .|...|||. .||.|            ||.|
  Fly   172 IDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERN-NNHNGSNGSNNNGMANNGNTV 235

Human   690 SKEMKRMGFEDPKDKN----------AQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF 744
            :......|.:...:.:          ||:|.:.:.:.::...|.:..:|.|..|.:|| :||:  
  Fly   236 NVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHV-QFLI-- 297

Human   745 REPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVI 809
            ||.::..|  .|||.:...                   ||..:..|     |...|     :|..
  Fly   298 REINVAAK--SQVDAKKDE-------------------VPDDMEFL-----CEAPL-----ISPA 331

Human   810 YSCVKLFPSPL------------QTLSRKIVR-SKMNSTLVGVFTITLVFLAAFVNMFTCNSRDL 861
            ..| |:||..|            :.:||.|.| ::.|.:|:.|       :.|.......|..::
  Fly   332 TFC-KVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEV-------VEAIRPHLQLNFENI 388

Human   862 LGCLAQEHNISASQVNACHVAESAVN-YSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFL 925
            |           |.:|..:|.::... .|...||.|..........||  |..:|          
  Fly   389 L-----------SHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPE--TDRIL---------- 430

Human   926 QISCIGKLVLMLAIELIYVLIVEVPGVTLFDNA-DLLVTANAIDFFNNGTSQWSLCENLRHRRME 989
             ..|...::.:..:....:.|.:||   |.|.| ||::.:...:      :::.|.:|       
  Fly   431 -FQCYPSVMNLDDLTKKGLYISDVP---LHDAARDLVLLSEKFE------AEYKLTKN------- 478

Human   990 AGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEM 1054
                                 |:::|.                           |||.|....|.
  Fly   479 ---------------------LEMLTD---------------------------KLQQTFRDLES 495

Human  1055 EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGV 1119
            |:.:  ..|||:::|||.| |:.|..:|......|.|   |.:||:.|..|.::.......:..:
  Fly   496 EKQK--TDRLLYSVLPKSV-ANELRHQRPVPPKRYDS---VTLMFSGIVGFGQYCAANTDPDGAM 554

Human  1120 ECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLM 1184
            :.:::|||:...||.:....|...:.|::|:|..|||.|||.|...|     |.|.:|..|:.:|
  Fly   555 KIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCED-----HAKCMARVALDMM 614

Human  1185 DQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDM 1249
            |..|.:...| |..|:.||::.|.||.||||.|.|:|.::|||||:.||.::||||.||.|:.:.
  Fly   615 DMAKNVKMGS-NPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEET 678

Human  1250 YQVLAA-----NTYQLECRGVVKVKGKGEMM-TYFL 1279
            |::|..     :::.||.||.|.:|||...| .:||
  Fly   679 YRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFL 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454
Guanylate_cyc 460..633 CDD:306677 26/108 (24%)
DUF1053 668..760 CDD:399378 29/117 (25%)
Guanylate_cyc 1087..1281 CDD:306677 73/199 (37%)
Gycbeta100BNP_524603.2 HNOB 2..164 CDD:285002 27/116 (23%)
HNOBA 326..516 CDD:285003 55/293 (19%)
CYCc 496..688 CDD:214485 73/203 (36%)
Guanylate_cyc 522..714 CDD:278633 71/200 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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