Protein Alignment ADCY5 and Gyc89Da

DIOPT Version :9

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 139/547 - (25%)
• Similarity: 239/547 - (43%)
• Gaps: 136/547 - (24%)

Human   813 VKLFPSPLQTLSR------------KIVRSKMNSTLVGVFTITL-VFLAAFVNMFTCNSRDLLGC 864
            :||...||..:.:            |.|.::.:.:.:.:.|:.| |||..|...|..|
  Fly   179 IKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLN------- 236

Human   865 LAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLAC-------- 921
                |::..:     |..|..|      |.....:|..|   |:.|..:.::.|..|
  Fly   237 ----HDMKIT-----HAGEKIV------ETWIMHNPGAN---PKSFIGTHVMDLFQCRRPKDTTI 283

Human   922 --SVFLQISCIGKLVLMLAIELI--------YVLIVEVPGVTLFDN--------ADLLVTANAID 968
              ...:|:..:     :...|||        |..::.:.    |:|        |..:..|.|.:
  Fly   284 DWDTLIQMRAV-----LFEFELIRTGHNRAAYDAVLNMD----FENYDEMDLNEAQTMALAKAQE 339

Human   969 FFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALK--------------VVTPIII 1019
            |..:......  |:.|...::     |:..:.:|.:....:.||              :.:|:|.
  Fly   340 FSESHPVDDD--ESAREDEID-----PATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIE 397

Human  1020 SVFVL---ALYLHAQQVESTARLDFL--W----KLQATEEKEEM--EELQ-------AYNRR--- 1063
            ::..|   .|||:.......:|...:  |    ||:...||||.  :||:       ::.|:
  Fly   398 NLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDE 462

Human  1064 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE-LEANNEGVECLRLLNE 1127
            ||::::|:.:|    .|.|.::|...||.|.|:|:|..:.|   .|.| |.:....::.:..||:
  Fly   463 LLYSMIPRPIA----ERMRLSEEQVCQSFEEVSVIFLEVMN---VYDEGLNSIQGAMQTVNTLNK 520

Human  1128 IIADFD-EIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYIN 1191
            :.:..| ||||...:    |::|:|..|||.||..|     |...|.:...|.|:::|.:.|
  Fly   521 VFSALDEEIISPFVY----KVETVGMVYMAVSGAPD-----VNPLHAEHACDLALRVMKKFK--- 573

Human  1192 EHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAAN 1256
            .|...:..:::|:|.|||||||:|.:.|:|.::|:|||.||||:|:..|.:||::......:...
  Fly   574 AHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQV 638

Human  1257 TYQLECRGVVKVKGKGEMMTYFLNGGP 1283
            .|::|.||.|:|||||:|.||:|..||
  Fly   639 GYKVESRGTVQVKGKGDMETYWLLEGP 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454
		Guanylate_cyc	460..633	CDD:306677
		DUF1053	668..760	CDD:399378
		Guanylate_cyc	1087..1281	CDD:306677	71/195 (36%)
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	57/302 (19%)
		CYCc	457..643	CDD:214485	66/204 (32%)
		Guanylate_cyc	485..662	CDD:278633	70/191 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810