DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADCY5 and CG31183

DIOPT Version :9

Sequence 1:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens
Sequence 2:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster

Alignment Length:	244	Identity:	78/244 - (31%)
Similarity:	132/244 - (54%)	Gaps:	35/244 - (14%)

- Green bases have known domain annotations that are detailed below.

Human  1049 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE 1113
            |||::.|       :||:.:||:.|||..::.:....|.:.|    |.:.|:.|..|:    .:.
  Fly   917 EEKKKCE-------KLLYQLLPQSVAAQLISGQPVVAETFDQ----VTIYFSDIVGFT----AIS 966

Human  1114 ANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALAD 1178
            |.:..::.::.||::...||.|:  :.| .:.|::|||..||..|||.    .:.|..|.:.:|.
  Fly   967 AESTPMQVVQFLNDLYTCFDSIV--ENF-DVYKVETIGDAYMVVSGLP----IRNGNQHAREIAR 1024

Human  1179 FAMKLMDQMKYINEHSF-------NNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDS 1236
            .|:.|::.:     |:|       :..:::|||:.|..||||:|.:.|:|.::|:|||.||||:|
  Fly  1025 LALALLEAV-----HNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMES 1084

Human  1237 TGVPDRIQVTTDMYQVL-AANTYQLECRGVVKVKGKGEMMTYFLNGGPP 1284
            .|...:|.::....:.| ...|:....||.|.:||||||:||:|.|..|
  Fly  1085 NGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVP 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454
		Guanylate_cyc	460..633	CDD:306677
		DUF1053	668..760	CDD:399378
		Guanylate_cyc	1087..1281	CDD:306677	64/201 (32%)
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003	11/27 (41%)
		CYCc	917..1108	CDD:214485	64/217 (29%)
		Guanylate_cyc	944..1130	CDD:278633	65/205 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810