Protein Alignment ADCY5 and Ac78C

DIOPT Version :10

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Alignment Length: 1624
• Identity: 458/1624 - (28%)
• Similarity: 702/1624 - (43%)
• Gaps: 449/1624 - (27%)

Human     2 SGSKSVSPP--GYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQ 64
            |.:|..:||  |....|:|||...|.|:.|.....|..:                    ||:...
  Fly    56 SDTKEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVDK--------------------GAIALA 100

Human    65 QQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGST- 128
            |...|  :...||||:..::|::  ..|.|.|..:.....:......|.|:......||...|:
  Fly   101 QIDDL--KLEGDDDDEAVVNGEE--VDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSE 161

Human   129 -----------------RAPPAG-----GGGGSAAAAASA-------------------GG---- 148
                             |.|..|     .|.|....:..|                   ||
  Fly   162 QDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAKQ 226

Human   149 TEVRPRSVEVGLEERRGKG--RAADELEAGAVEGGEGSGDGGSSADS--GSGAGP---------- 199
            |.:|.:||.: :|.:|..|  |..:..........|...:.|:|..|  |....|
  Fly   227 TPLRVQSVRI-VEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAFK 290

Human   200 -GAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAF---- 259
             |.|:. |..|.:|     :..|....|||.|..|..|..|.|| :::.|:..|..::|||
  Fly   291 SGNVVK-GILCPSL-----TNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFVWIM 348

Human   260 -HAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL-ACYALIAVVLAVQVVGLLLPQP 322
             .:...|::......:|.|:    ..:|.|..|......:|. .|:|...:..|.....:|....
  Fly   349 RRSELGPIESDDGTSMATAI----TWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQ 409

Human   323 RSASEG---------IWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQ------- 371
            ....:|         :|:.:|.|:..|.:||:.::..|:.|.:.::.|||:......|
  Fly   410 GFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATIN 474

Human   372 DQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVL 436
            .:.:|.|:.:|.::::..|:.|:.|.|..:..||.||.||.:.::.:..|::|.|:.::||.|:|
  Fly   475 PECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSIL 539

Human   437 PRHVAMEMKADINAKQE---DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELF 498
            |..|..::::::....:   :..|:|:|:...||||||||||:|||.|||:.:||:||..||:||
  Fly   540 PNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLF 604

Human   499 ARFDKLAAENHCLRIKILGDCYYCVSGLP----EARADHAHCCVEMGMDMIEAISLVREVTGVNV 559
            ||||::|.:|||||:|:|||||||||...    :.|.|||.|.||.|:.||:||..||..|.|::
  Fly   605 ARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDL 669

Human   560 NMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGC 624
            |||:|||||.|.|||||.:||.||||||||.:|||||:||..||:||::|||..||..||||||.
  Fly   670 NMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGN 734

Human   625 GGERNAYLKEHSIETFLILR----------------------------CT--------------- 646
            ||.|:.:||..:::|:||.|                            |.
  Fly   735 GGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSG 799

Human   647 --------------------------------------QKRKEEKAM---------IAKMNRQRT 664
                                                  |::|:..::         :|..:|:..
  Fly   800 SIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIR 864

Human   665 NSIG------------------------------------------------------------- 668
            |..|
  Fly   865 NGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIED 929

Human   669 HNPPHWGAERPFYNHLGGNQVSKEMKRMG--FEDPKDKNAQESANPEDEVDEFLGRAIDARSIDR 731
            .:...|..|.||.|.   |.....:.|..  ..|.|:.:....|..::|:|||:.:.|...|...
  Fly   930 ESTTDWIPEIPFKNL---NSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKE 991

Human   732 LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTC 796
            :|.|::..:.|.|::...|:|:.:..:|.|.:.:.|..::::|:...|:.|:|.          |
  Fly   992 IRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPR----------C 1046

Human   797 SLLLTLVVFVSVI--YSCVKL-------FPSPLQTLSRKIVRSKMNSTL--VGVFTITLVFLAAF 850
            :.|:..:...:||  :.||.:       .|..|:|.|.|:|..:...||  .||. :::..|:|
  Fly  1047 TRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVI-VSMCMLSA- 1109

Human   851 VNMFTCNSRDLLGCLAQEH-----------NIS-------------------------------- 872
            :.:..|.|...:| .|.||           |||
  Fly  1110 IGLVLCPSSTYIG-TADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTP 1173

Human   873 --------------ASQVNACHV-----------------------------AESAVNYSLGDEQ 894
                          .|.:||..:                             ::::|..|..|.:
  Fly  1174 LVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVE 1238

Human   895 GFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNAD 959
            |       .|..|||..::.:|.|::.:..|::..:.|.::.||:...|..::.:.
  Fly  1239 G-------QCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMK--------- 1287

Human   960 LLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVL 1024
                      |.:|.| :||.|..|       ...|.||:              :..::||..|:
  Fly  1288 ----------FGSGDS-FSLVELSR-------LGMPLGVQ--------------MLILLISFLVM 1320

Human  1025 ALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 1089
            ..| ||:.||.|:||||:||.||..|...|:..:|.|..|:.||||..||.::|:.| ..||||.
  Fly  1321 VCY-HARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDE-HTDELYS 1383

Human  1090 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTY 1154
            :......||||||.||.:||.| :.:| |..|:|:|||||.||||::.|.||..:|||||:|:||
  Fly  1384 KMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATY 1446

Human  1155 MAASGLNDSTYDKVGKT---HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGA 1216
            |||:|||.......|:|   .:..|.:||..:..:::.||..:|||||:::|:..||:|:|||||
  Fly  1447 MAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGA 1511

Human  1217 RKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1280
            |||.||||||||||||||||||...|:||..:..::|.:..|....||.:.|||||.|.|::::
  Fly  1512 RKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	118/543 (22%)
		Guanylate_cyc	460..643	CDD:425528	114/186 (61%)
		Adcy_cons_dom	668..761	CDD:461877	24/155 (15%)
		Guanylate_cyc	1087..1281	CDD:425528	99/197 (50%)
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	82/346 (24%)
		Guanylate_cyc	566..753	CDD:425528	114/186 (61%)
		Adcy_cons_dom	929..1021	CDD:461877	23/94 (24%)
		Guanylate_cyc	1381..1576	CDD:425528	99/197 (50%)