DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ADCY5 and Ac76E

DIOPT Version :9

Sequence 1:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens
Sequence 2:NP_001246838.1 Gene:Ac76E / 40180 FlyBaseID:FBgn0004852 Length:1312 Species:Drosophila melanogaster


Alignment Length:1442 Identity:436/1442 - (30%)
Similarity:626/1442 - (43%) Gaps:435/1442 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   130 APPAGGGGGSAAAA---ASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSA 191
            |..|..|.|:.|.|   ..|.|...:|:::      .....|..|.|.|...:..|  .:.|::|
  Fly     6 AETAKTGNGTNATANLIVKADGNATQPKAM------TSSAARMNDALSASLADLSE--QENGTTA 62

Human   192 DSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS-----SLTMLMAVLVL 251
            :                              ...|..||.||..||.:|     .||.|:|.:|.
  Fly    63 E------------------------------DIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVS 97

Human   252 VCL-VMLAFHAARPPLQLPYLAVLAAAV-GVIL----IMAVLCNRAAFHQDHMGLACYALIAVVL 310
            :.: ::...|     |....|.||||.: |.||    ..|||.:.||      .|| :|::....
  Fly    98 IIIGIVYGQH-----LVQTMLLVLAALISGSILTALQFPAVLSSPAA------ALA-FAIVTTFS 150

Human   311 AVQVVGL----LLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQ 371
            ...:..:    |.|.|..|         ....|:::||:....:|:..:.::|:|:...:.|:..
  Fly   151 LGTIAAITGDELAPLPMYA---------LFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPD 206

Human   372 DQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVL 436
            ....|..|...:::.:..::.|:.....::.:..:....||..|:.|:..:.|.:|||:|||||:
  Fly   207 YAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVI 271

Human   437 PRHVAMEMKADINAKQED-------------MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ 488
            |.::|.|:|..|..|..|             ..||::::|:|.||:||||||..||.|:|..||.
  Fly   272 PAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTAS 336

Human   489 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVRE 553
            :||.|||:||.|||::|.||.||||||||||||||||||.:|..||..||.||:.||:||..|||
  Fly   337 DLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVRE 401

Human   554 VTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDY 618
            .||:||:||:|||:|.|.|||||||||||||||:|||||||||:||.|||:||||.||::|...:
  Fly   402 ATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKF 466

Human   619 EVEPGCGGERNAYLKEHSIETFLI--------------LRC---------TQKRKE--------- 651
            |||.|.||.|:|||.:|.:|::||              :.|         |::.||         
  Fly   467 EVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHE 531

Human   652 ---------------------EKAMIAKMNRQR-------------------------------T 664
                                 ||.....:|.|.                               |
  Fly   532 ATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVT 596

Human   665 NSIGH---------NPPHWGAERPFYNHLGGNQVSKE----------MKRMGFEDP-KDKNAQ-E 708
            ..:.|         .|...|..|...:......|:|.          :...|.|.. .:..|| :
  Fly   597 EPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQ 661

Human   709 SANPED--------------------EVDEFLGRAIDARSI----DRLRSE-------------- 735
            |:||..                    |..|...|.:..:.:    ||.||.              
  Fly   662 SSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSG 726

Human   736 --------HV------------------------------------------------------- 737
                    ||                                                       
  Fly   727 ESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFN 791

Human   738 ----------RKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSF 792
                      :.|.:.:|....|..|..|.|..|...:.||.::||.:..||:.::..::.:|..
  Fly   792 FNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGS 856

Human   793 YLTCSLLLTLVVFVS-----VIYSCVKLFPSPLQTL-SRKIVRSKMNSTLVGVFTITLVFLAAFV 851
            .|...:.|.|.:::|     .:::.......|.|.: |.:.:|                 ||.||
  Fly   857 LLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLR-----------------LAMFV 904

Human   852 NMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPN-----CNFPEYFT 911
            .:                ||   .:::|.|. |.:||::.|  |....|..|     .||...|.
  Fly   905 VV----------------NI---LISSCAVF-SVINYTVPD--GVSKEPSSNQTILESNFSSVFV 947

Human   912 YSVL-----------------------LSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVT 953
            .|.|                       :||.|.|.||:...|.||:.|        |:..:..||
  Fly   948 NSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAM--------LVAVIAQVT 1004

Human   954 LFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPII 1018
            :...:||      .:.:|:.        |:.|                      .:.|::...::
  Fly  1005 VLGYSDL------FEMYNDA--------NITH----------------------GLPLEIKGFLL 1033

Human  1019 ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR 1083
            :.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.|||..| |
  Fly  1034 LLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE-R 1097

Human  1084 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIK 1148
            :.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.:|..:||||
  Fly  1098 STELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIK 1162

Human  1149 TIGSTYMAASGLNDSTYD-----------KVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKI 1202
            ||.||||.||||.....|           :..:.::..|.:||:.||..:..||..||..|:::|
  Fly  1163 TIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRI 1227

Human  1203 GLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK 1267
            |||.|||:||||||:|||||||.|||||||||||.||..|:|.|.:..::|....|:.||||:..
  Fly  1228 GLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTY 1292

Human  1268 VKGKGEMMTYFL 1279
            |||||.::|||:
  Fly  1293 VKGKGNLVTYFV 1304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454 81/358 (23%)
Guanylate_cyc 460..633 CDD:306677 117/172 (68%)
DUF1053 668..760 CDD:399378 28/223 (13%)
Guanylate_cyc 1087..1281 CDD:306677 108/204 (53%)
Ac76ENP_001246838.1 AC_N <67..289 CDD:292831 64/242 (26%)
CYCc 259..467 CDD:214485 126/207 (61%)
Guanylate_cyc 311..469 CDD:278633 109/157 (69%)
BASP1 510..667 CDD:283191 21/156 (13%)
CYCc 1079..1283 CDD:214485 109/204 (53%)
Guanylate_cyc 1101..1305 CDD:278633 108/204 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.810

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