Protein Alignment ADCY5 and CG43373

DIOPT Version :10

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Alignment Length: 1586
• Identity: 584/1586 - (36%)
• Similarity: 794/1586 - (50%)
• Gaps: 404/1586 - (25%)

Human     1 MSGSKSVSPPGYAAQKTAAPAPRGGPEH--RSAWGEADSR-------ANGYPHAPGGSARGSTKK 56
            |||.     ||..:....|....||..|  ||...|:..|       ..|..|  ||:|.|
  Fly     1 MSGG-----PGAGSGGAVAGGVGGGATHIFRSLSSESQKREWSKRLSLRGMRH--GGAAGG---- 54

Human    57 PGGAVTPQ-QQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSR---- 116
            |||:.|.. ...:..|:.|........|.......||.|.           ||...|.||.
  Fly    55 PGGSGTSSLASSKEESKHRKFFSRSASLRQAGSGGGGVGV-----------GGVVGGSGSHQASM 108

Human   117 ------RQRRGAASG-GS--TRAPPA---------------GGGGGSAAAAASAGGTEVRPRSVE 157
                  ::.||.:|| ||  |:..|:               ...||.|..::|.....:...:::
  Fly   109 ELHVPGQEGRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGGKAVVSSSLIAAGITRCNID 173

Human   158 VGLEERRGKGRAADEL-----EAGAVEGGEGSG-DGGSSADSGSGAGP--GAVLSLGACCLAL-- 212
            ..::...........:     |...::.|:.|. :..:...||.|.|.  |.|....:....|
  Fly   174 ESMDSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVSPSISFWFRLNR 238

Human   213 --LQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVM------------------- 256
              |::..:.:|.:.::|.||||||.|:|||:.|.::|:|:.:.|.:
  Fly   239 IILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILALSCTLLVFTTLQLRRSTSLL 303

Human   257 ----------------LAFHAARPPL-----------QLPYLAVLA-------AAVG-------- 279
                            |.....:||.           .:|.||:.:       .|||
  Fly   304 LEISEIGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHN 368

Human   280 ----------------------------------------------------------------- 279
                                                                             
  Fly   369 HNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQT 433

Human   280 ----------------------------------------------------------------- 279
                                                                             
  Fly   434 QLIVDTATDDDADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGV 498

Human   280 ---------------------------VILIMAVLC-----------NRAAFHQDHMGLACYALI 306
                                       |.||:.::|           ::.|.::..:.|..|.::
  Fly   499 ATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVIL 563

Human   307 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNA- 370
            ...||::|......||..:..|....:..||..||:||:|:|.|::.|:|||.:||...||.||
  Fly   564 GTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAM 628

Human   371 QDQFL----LKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERL 431
            ||:.:    .::|:..::.....|:.||.||:|.|.:||:||.|||:||:|||.:||||||||||
  Fly   629 QDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERL 693

Human   432 LLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNE 496
            ||||||||||||||.||..:..|..|||||||:|:|||||||||.|||||:.||||:|||..|||
  Fly   694 LLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNE 758

Human   497 LFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNM 561
            ||||||:||||:||||||:|||||||||||||.|.|||||.||||:|||:||:|||||..|||||
  Fly   759 LFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNM 823

Human   562 RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGG 626
            |||||:||||||||||.||||||||||||||||||:||..||:||||.||..|:||||||.|.|.
  Fly   824 RVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGN 888

Human   627 ERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSK 691
            |||:|||:|.|||:||:.....|..:|:    .||.:.|                    || :||
  Fly   889 ERNSYLKDHQIETYLIVPGDIYRPHKKS----RNRLQVN--------------------GN-ISK 928

Human   692 EMKRM------------GFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF 744
            |::.|            ||.|    :::.:.:|||||:|:|.|||||||||.||:||.:..||.|
  Fly   929 ELRMMGHGTAQKHTSKFGFGD----SSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCF 989

Human   745 REPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVI 809
            ::..||:||:.:.|.....|..|:.||.|....:::.:...|:..|:......|||..:||   :
  Fly   990 KDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVF---L 1051

Human   810 YSCVKL---FPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI 871
            .:|.|:   .||.::..|.:|..::..|.|....::.|:.|...:.||..:.|.:.  |.|....
  Fly  1052 VACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQME--LLQRRRF 1114

Human   872 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLM 936
            ......:..:.::.:|..:.|.:.      |:|:|  |..|:..|.|...|:   :||....||.
  Fly  1115 WLDVNGSISLNDTELNTKMYDAEE------PDCDF--YLAYNTFLLLTLLSM---MSCATYQVLR 1168

Human   937 LAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQ 1001
            :.::|:.:|:                          .:..:..|.:..:.|.          :|.
  Fly  1169 ILLKLLLLLL--------------------------ASGSYMACSSNLYSRS----------REM 1197

Human  1002 SPEHATKVAL--KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRL 1064
            |.|.|.:.||  .::..|.:..|:|||..|:.|.|:|.||||:||||||||||:||.||||||:|
  Fly  1198 SQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKL 1262

Human  1065 LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEII 1129
            |.||||..||.|||:||:..|:||::.|:.|.::||||.||||||||||.|||||||||||||||
  Fly  1263 LENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEII 1327

Human  1130 ADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHS 1194
            |||||::||:|||.:||||:.|:||||||||..:|.|:|..:|:.|:||:|::|.|:::.:|.||
  Fly  1328 ADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHS 1392

Human  1195 FNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQ 1259
            ||||:|:||:||||||||||||.|||||||||.|||||||||||:.|.||||.:|.|:|....::
  Fly  1393 FNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFE 1457

Human  1260 LECRGVVKVKGKGEMMTYFLNGGPPL 1285
            |.|||.|.|||||.|:||||.|..|:
  Fly  1458 LTCRGSVDVKGKGSMITYFLKGRRPI 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	163/740 (22%)
		Guanylate_cyc	460..643	CDD:425528	146/182 (80%)
		Adcy_cons_dom	668..761	CDD:461877	37/104 (36%)
		Guanylate_cyc	1087..1281	CDD:425528	131/193 (68%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	81/196 (41%)
		Guanylate_cyc	722..904	CDD:425528	145/181 (80%)
		Adcy_cons_dom	<949..1005	CDD:461877	29/59 (49%)
		Guanylate_cyc	1285..1479	CDD:425528	131/193 (68%)