DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCY5 and CG43373

DIOPT Version :9

Sequence 1:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens
Sequence 2:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster

Alignment Length:	1586	Identity:	584/1586 - (36%)
Similarity:	794/1586 - (50%)	Gaps:	404/1586 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSGSKSVSPPGYAAQKTAAPAPRGGPEH--RSAWGEADSR-------ANGYPHAPGGSARGSTKK 56
            |||.     ||..:....|....||..|  ||...|:..|       ..|..|  ||:|.|
  Fly     1 MSGG-----PGAGSGGAVAGGVGGGATHIFRSLSSESQKREWSKRLSLRGMRH--GGAAGG---- 54

Human    57 PGGAVTPQ-QQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSR---- 116
            |||:.|.. ...:..|:.|........|.......||.|.           ||...|.||.
  Fly    55 PGGSGTSSLASSKEESKHRKFFSRSASLRQAGSGGGGVGV-----------GGVVGGSGSHQASM 108

Human   117 ------RQRRGAASG-GS--TRAPPA---------------GGGGGSAAAAASAGGTEVRPRSVE 157
                  ::.||.:|| ||  |:..|:               ...||.|..::|.....:...:::
  Fly   109 ELHVPGQEGRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGGKAVVSSSLIAAGITRCNID 173

Human   158 VGLEERRGKGRAADEL-----EAGAVEGGEGSG-DGGSSADSGSGAGP--GAVLSLGACCLAL-- 212
            ..::...........:     |...::.|:.|. :..:...||.|.|.  |.|....:....|
  Fly   174 ESMDSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVSPSISFWFRLNR 238

Human   213 --LQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVM------------------- 256
              |::..:.:|.:.::|.||||||.|:|||:.|.::|:|:.:.|.:
  Fly   239 IILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILALSCTLLVFTTLQLRRSTSLL 303

Human   257 ----------------LAFHAARPPL-----------QLPYLAVLA-------AAVG-------- 279
                            |.....:||.           .:|.||:.:       .|||
  Fly   304 LEISEIGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHN 368

Human   280 ----------------------------------------------------------------- 279

  Fly   369 HNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQT 433

Human   280 ----------------------------------------------------------------- 279

  Fly   434 QLIVDTATDDDADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGV 498

Human   280 ---------------------------VILIMAVLC-----------NRAAFHQDHMGLACYALI 306
                                       |.||:.::|           ::.|.::..:.|..|.::
  Fly   499 ATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVIL 563

Human   307 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNA- 370
            ...||::|......||..:..|....:..||..||:||:|:|.|::.|:|||.:||...||.||
  Fly   564 GTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAM 628

Human   371 QDQFL----LKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERL 431
            ||:.:    .::|:..::.....|:.||.||:|.|.:||:||.|||:||:|||.:||||||||||
  Fly   629 QDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERL 693

Human   432 LLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNE 496
            ||||||||||||||.||..:..|..|||||||:|:|||||||||.|||||:.||||:|||..|||
  Fly   694 LLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNE 758

Human   497 LFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNM 561
            ||||||:||||:||||||:|||||||||||||.|.|||||.||||:|||:||:|||||..|||||
  Fly   759 LFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNM 823

Human   562 RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGG 626
            |||||:||||||||||.||||||||||||||||||:||..||:||||.||..|:||||||.|.|.
  Fly   824 RVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGN 888

Human   627 ERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSK 691
            |||:|||:|.|||:||:.....|..:|:    .||.:.|                    || :||
  Fly   889 ERNSYLKDHQIETYLIVPGDIYRPHKKS----RNRLQVN--------------------GN-ISK 928

Human   692 EMKRM------------GFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF 744
            |::.|            ||.|    :::.:.:|||||:|:|.|||||||||.||:||.:..||.|
  Fly   929 ELRMMGHGTAQKHTSKFGFGD----SSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCF 989

Human   745 REPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVI 809
            ::..||:||:.:.|.....|..|:.||.|....:::.:...|:..|:......|||..:||   :
  Fly   990 KDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVF---L 1051

Human   810 YSCVKL---FPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI 871
            .:|.|:   .||.::..|.:|..::..|.|....::.|:.|...:.||..:.|.:.  |.|....
  Fly  1052 VACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQME--LLQRRRF 1114

Human   872 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLM 936
            ......:..:.::.:|..:.|.:.      |:|:|  |..|:..|.|...|:   :||....||.
  Fly  1115 WLDVNGSISLNDTELNTKMYDAEE------PDCDF--YLAYNTFLLLTLLSM---MSCATYQVLR 1168

Human   937 LAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQ 1001
            :.::|:.:|:                          .:..:..|.:..:.|.          :|.
  Fly  1169 ILLKLLLLLL--------------------------ASGSYMACSSNLYSRS----------REM 1197

Human  1002 SPEHATKVAL--KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRL 1064
            |.|.|.:.||  .::..|.:..|:|||..|:.|.|:|.||||:||||||||||:||.||||||:|
  Fly  1198 SQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKL 1262

Human  1065 LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEII 1129
            |.||||..||.|||:||:..|:||::.|:.|.::||||.||||||||||.|||||||||||||||
  Fly  1263 LENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEII 1327

Human  1130 ADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHS 1194
            |||||::||:|||.:||||:.|:||||||||..:|.|:|..:|:.|:||:|::|.|:::.:|.||
  Fly  1328 ADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHS 1392

Human  1195 FNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQ 1259
            ||||:|:||:||||||||||||.|||||||||.|||||||||||:.|.||||.:|.|:|....::
  Fly  1393 FNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFE 1457

Human  1260 LECRGVVKVKGKGEMMTYFLNGGPPL 1285
            |.|||.|.|||||.|:||||.|..|:
  Fly  1458 LTCRGSVDVKGKGSMITYFLKGRRPI 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	163/740 (22%)
		Guanylate_cyc	460..633	CDD:306677	139/172 (81%)
		DUF1053	668..760	CDD:399378	37/103 (36%)
		Guanylate_cyc	1087..1281	CDD:306677	131/193 (68%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	81/196 (41%)
		CYCc	686..881	CDD:214485	157/194 (81%)
		Guanylate_cyc	722..895	CDD:278633	139/172 (81%)
		DUF1053	<949..1005	CDD:283888	29/59 (49%)
		CYCc	1259..1455	CDD:214485	132/195 (68%)
		Guanylate_cyc	1285..1479	CDD:278633	131/193 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146879
Domainoid	1	1.000	286	1.000	Domainoid score	I1607
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11213
Inparanoid	1	1.050	950	1.000	Inparanoid score	I339
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002306
OrthoInspector	1	1.000	-	-		otm41302
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4931
SonicParanoid	1	1.000	-	-		X1998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.780