DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADCY5 and CG10738

DIOPT Version :9

Sequence 1:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens
Sequence 2:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	89/295 - (30%)
Similarity:	141/295 - (47%)	Gaps:	43/295 - (14%)

- Green bases have known domain annotations that are detailed below.

Human  1000 EQSPEHAT-----KVALKVVTPIIISVFVLALYLHAQQVESTA--RLDFLWKLQATEEKEEMEEL 1057
            |..|:..|     :...|.:.|.|....:..:..:|..:|:..  |.|     |..|||::.:
  Fly   835 EDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTD-----QLQEEKKKTD-- 892

Human  1058 QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1122
                 .|||.:||:.||.......:.:.|.|.|    |::.|:.|..|:    .:.|....::.:
  Fly   893 -----ALLHEMLPRCVADQLKKGHKVDPEHYEQ----VSIYFSDIVGFT----AMSAECTPLQVV 944

Human  1123 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL---NDSTYDKVGKTHIKALADFAMKLM 1184
            ..||::...||.||..   ..:.|::|||..||..|||   |       |..|...:|..::.|:
  Fly   945 DFLNDLYTCFDSIIGH---YDVYKVETIGDAYMVVSGLPLRN-------GDLHAAEIATMSLHLL 999

Human  1185 DQMK--YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTT 1247
            ..:.  .|.....|...::||::.|||.|||:|.:.|:|.::|:|||.||||:|:|||.:|..:.
  Fly  1000 SAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSW 1064

Human  1248 DMYQVL-AANTYQLECRGVVKVKGKGEMMTYFLNG 1281
            ...|:| ....|....|||:.:||||:..||:|.|
  Fly  1065 QCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLG 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454
		Guanylate_cyc	460..633	CDD:306677
		DUF1053	668..760	CDD:399378
		Guanylate_cyc	1087..1281	CDD:306677	66/199 (33%)
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	3/17 (18%)
		TyrKc	597..847	CDD:197581	3/11 (27%)
		HNOBA	<862..907	CDD:285003	15/56 (27%)
		CYCc	886..1078	CDD:214485	67/216 (31%)
		Guanylate_cyc	913..1099	CDD:278633	67/203 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810