Protein Alignment ADCY5 and CG32301

DIOPT Version :10

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Alignment Length: 1174
• Identity: 301/1174 - (25%)
• Similarity: 502/1174 - (42%)
• Gaps: 248/1174 - (21%)

Human   225 KLERLYQRYFFRLNQSSLTMLMAVLVLVCL--VMLAFHAARPPLQLPYLAVLAAAVGVILIMAVL 287
            :||.:|.|:...::.:.:|.|:.|:.::.|  |:|.|...:   .:.:|.||.....::|..::|
  Fly    34 RLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVK---NIDFLTVLPYFAVMLLTPSIL 95

Human   288 C-NRAAFHQDHMGLACYALIAVVLAVQVVGLLLP----QPRSASEGIWWTVF-FIYTIYTLLPVR 346
            . :|....:.:..:|......:.|.:..:.|:||    :|.|........|. .||.::.:..|:
  Fly    96 MPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDHVVIVLIYLMFPIAFVK 160

Human   347 MRAAVLSGVLLSAL---HLAIALRTNAQDQ-----------FLLKQLVSNVLIFSCTNIVGVCTH 397
            ...|...|:.:|..   ::|:..:.:..|:           |.|..|...:..|.
  Fly   161 NGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQ---------- 215

Human   398 YPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQED-----MMF 457
               |.:.|.......:.:...|..|...::::.||.|::|..:|..::..|.:..|:     |.|
  Fly   216 ---EYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPF 277

Human   458 HK---IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDC 519
            .|   ::::.|..||||.||:..||.|.:.....:||..|:|||..||..|..|...|||.|||.
  Fly   278 TKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDS 342

Human   520 YYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDV 584
            |.||:|:|.....||:.||...:||||....|.:.....:::|:|:|||.:..|::||.|||||:
  Fly   343 YTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDI 407

Human   585 WSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCG-GERNAYLKEHSIETFLI------ 642
            ||.||.:.|.:|:.|..|.:||:..||..|:..|..|.|.. .:.:..|:..::.|:||
  Fly   408 WSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPN 472

Human   643 LRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPF---YNHLGGNQVSK-EMKRMGFEDPKD 703
            ...|...:::...:.......:.|..:......|:|..   ..|:..|:|.. :::|     |..
  Fly   473 FEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRR-----PMH 532

Human   704 KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLL--TFREPDLEKKYSKQVD----DRFG 762
            :.|:|..|.|...                   |:..:.|  |||...:|..::|..|    ...|
  Fly   533 RIAKEDINEEYRF-------------------HLESYYLFTTFRSWRMEWSFNKMRDLLMKYSLG 578

Human   763 AYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFP--SPLQTLSR 825
            ..|...:.:......|:...:.::: :.|.:|...|.|.|..:..:.....:|.|  .|...|||
  Fly   579 MMVFAGATIIAMDLLVKSEAMDYTM-LFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSR 642

Human   826 KIVRSKMNSTLV--GVFT-ITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAE---S 884
            ..:::   |.|:  .||. |.|..:..|          ||      :.:|:..|.:|.:|.   .
  Fly   643 WFIKA---SDLIEKSVFVRIPLAIMVLF----------LL------YVMSSETVFSCDIARLELE 688

Human   885 AVNYSLGD--EQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIV 947
            .:|..|.:  .|..|..||.       .||:|::.|....|.:.|..|.||.:.|||...:|:.|
  Fly   689 IINSELHNLRPQMLCFMPWG-------VTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITV 746

Human   948 EVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALK 1012
            .......|:.:.              |:...:..:|.|
  Fly   747 HAYYGFAFERSQ--------------TTNIGVTSSLAH--------------------------- 770

Human  1013 VVTPIIISVFVLALYLHAQQVESTARLDFLWKL-----QATEEKEEMEELQAYN-RRLLHNILPK 1071
                   |.:::|.::..  |.....|:::.|.     ...|:|.|:.:::... :.::.||||.
  Fly   771 -------SWYMVAFFIVV--VVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPT 826

Human  1072 DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDE-I 1135
            .||..|..| ||:|:|||::...||||||:|.|:       ||:..|   ||.|:|:|..||| :
  Fly   827 HVAEVFKVR-RRSDQLYYENFSQVAVMFATIENY-------EADKSG---LRALHEMICYFDELL 880

Human  1136 ISEDRFRQLEKIKTIGSTYMAASGLNDSTY---------------DKVGKT-------------- 1171
            ::...:.::||||.:|.||:||.||:...|               ||:.|:
  Fly   881 VNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIM 945

Human  1172 ----H------------IKALADFAMKLMDQMK-------YINEHSFNNFQMKIGLNIGPVVAGV 1213
                |            |..:.:||:.|:..::       :..:.|.....:|||:..|||:|||
  Fly   946 IKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGV 1010

Human  1214 IGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMT 1276
            :|..||.|||||:|||:||||.||||.|.|.||.....||  ..:.:.|  ||:..|||.|::.|
  Fly  1011 VGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVL--RDFNIRCTYRGMTFVKGVGQVPT 1073

Human  1277 YFLN 1280
            |.::
  Fly  1074 YLVD 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	49/259 (19%)
		Guanylate_cyc	460..643	CDD:425528	73/189 (39%)
		Adcy_cons_dom	668..761	CDD:461877	19/102 (19%)
		Guanylate_cyc	1087..1281	CDD:425528	86/249 (35%)
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	114/409 (28%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	66/155 (43%)
		AcyC	681..1076	CDD:441717	130/464 (28%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	86/246 (35%)