Protein Alignment ADCY5 and ACXD

DIOPT Version :9

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Alignment Length: 1213
• Identity: 334/1213 - (27%)
• Similarity: 548/1213 - (45%)
• Gaps: 276/1213 - (22%)

Human   225 KLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVL-C 288
            :||..|..|..||....|::.:.:.|.|.::........|.::..|:.::|.....::|..|| .
  Fly    48 ELEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVLGV 112

Human   289 N-RAAFHQDHMGLACYA---LIAVVLAVQVVGLLLPQPRSASEGI--WWTVFFIYTIYTLLPV-- 345
            | |:.....| |...||   |...|:.:..:||.:....|.::.:  .:..:.:|.||..:||
  Fly   113 NFRSELVSKH-GWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPY 176

Human   346 RMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQE 410
            .::..||...:.....:..:....|:|...:..:::..:..||.|::|:......:::.|..|.:
  Fly   177 LLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLD 241

Human   411 TRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADI-----NAKQEDMMFHKI---------- 460
            .|:.::..|..:....|:..||||:||..:|..::.|:     .:||:.....::
  Fly   242 RRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQT 306

Human   461 ------------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI 513
                        :|:.|::|::|:||:..:|.|.:....::||..|::||.|||..:.|.:.|||
  Fly   307 LKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRI 371

Human   514 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 578
            |.||||||||:||....||||.|||::|:.||:.|..|||...:|::||:|:|||.|..||:|..
  Fly   372 KFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAA 436

Human   579 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGER-NAYLKEHSIETFLI 642
            |||||:||.||.:||.:||.|..||:|:::.||:.|:|:|..|.|....| :..|::|.|.||||
  Fly   437 KWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLI 501

Human   643 --LRCTQ---KRKEEKAMIAKMNRQRTNSIGHNPP-HWGAERPFYNHLGGNQVSKEMKRMGFEDP 701
              ||...   :|:..:..:.|::.....:..||.. |.      ||.: .||...||.|
  Fly   502 KSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQ------YNQV-RNQAKLEMCR------ 553

Human   702 KDKNAQESANPEDEVDEF-LGR----AIDARSI----DRLRSEHVRKFL----LTFREPDLEKKY 753
                         |:|:. :||    .:..||.    |.:..|..|:.:    |.||..:.|.:|
  Fly   554 -------------ELDKMPIGRIQLTKVFRRSTRLTQDEIEEETFRRNISSCCLFFRIRNWEFQY 605

Human   754 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLS-------FYL--TCSLLLTLVVFVS-- 807
            .|:.|......:|.|.::::.:..:|         :||       :|:  |..:|||:::.||
  Fly   606 IKEPDVMLKYSIALAWVIYMGLLTIQ---------LLSKDARYHYWYIDGTTIILLTMLLIVSWY 661

Human   808 ----VIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQE 868
                ::|.......||...||..:.|.........|..:.:.||..| :........::||.:.|
  Fly   662 KKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIF-SYCAVAIMQVVGCSSDE 725

Human   869 HNISASQVNACHVAESAVNYSLGDEQGFCGSPW--PNCNFPEYFTYSVLLSLLACSV-FLQISCI 930
                       ..|:....|   ||:..|..||  .||     .|..:.:|.|...: |:..||.
  Fly   726 -----------DYADLDPTY---DERVQCFHPWILTNC-----MTLVIGMSFLFTRIPFIIKSCF 771

Human   931 GKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFP 995
            ..|::     :.|.::|    |:.|:    .:.||:.....|..:::|
  Fly   772 SALIM-----IGYAVLV----VSEFN----FIYANSPSTNVNFNAKYS----------------- 806

Human   996 SGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAY 1060
                        .:.|.::|   ..:|    :|..:|.|..|::|:.||.|..:::|:.......
  Fly   807 ------------HILLMIIT---FGIF----HLMERQTEFIAKVDYNWKRQLIKKQEDALITNDT 852

Human  1061 NRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLL 1125
            .:.||.||||..||..:|:.:.:| ||||:..:.||||||||.||       :.:..|   ||:|
  Fly   853 IKVLLTNILPTHVADFYLSNQLQN-ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVL 906

Human  1126 NEIIADFDEIISE-DRFRQLEKIKTIGSTYMAASGLN------------------------DSTY 1165
            ||||.|||::::: .:..::||||....|||||.||:                        .|.|
  Fly   907 NEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRY 971

Human  1166 D-----------------------------------------KVGKTH--------IKALADFAM 1181
            |                                         ::..||        ::.:|:||:
  Fly   972 DGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFAL 1036

Human  1182 KLMDQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG 1238
            .||..|:..|        |.|.:...::||::.|..:|||:|..||.||||||.||:||||||||
  Fly  1037 DLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTG 1101

Human  1239 VPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1279
            ||.:||||.:  ..|....:.::|  ||:..|||:|.:.||.:
  Fly  1102 VPGQIQVTEN--TALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	54/246 (22%)
		Guanylate_cyc	460..633	CDD:306677	81/195 (42%)
		DUF1053	668..760	CDD:399378	26/105 (25%)
		Guanylate_cyc	1087..1281	CDD:306677	90/277 (32%)
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	52/236 (22%)
		CYCc	254..476	CDD:214485	88/221 (40%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	87/181 (48%)
		CYCc	856..1117	CDD:214485	92/273 (34%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	90/275 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910