Protein Alignment ADCY5 and Ac3

DIOPT Version :9

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Alignment Length: 1165
• Identity: 374/1165 - (32%)
• Similarity: 591/1165 - (50%)
• Gaps: 177/1165 - (15%)

Human   189 SSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLT--MLMAVLVL 251
            |....|.|...|.|:.|                |...|..||..|..:..:|.|.  :..|.|..
  Fly    33 SDVAGGVGITGGGVVIL----------------PQHVLNELYHNYSIKQRRSGLKWFVFAAALFN 81

Human   252 VCLVMLAFHAARPP------LQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVL 310
            :..:.:.:..:.|.      :.|.|||:.|     :|.:....::.|..:.|..|    ||.|..
  Fly    82 IWTIGIPWDQSAPTRVINCCMLLAYLALTA-----LLHIGRRSDKPALRRFHQIL----LIIVPR 137

Human   311 AVQVVGLL------LPQPR-SASEGIWWTVFFIYTIYTLLPVRMRAAVLS-GVLLSALHLAIALR 367
            |:.::.:|      :.||. |..:.:.|.:...:.:|..||:::....|| |.:...:.|::.:.
  Fly   138 ALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVG 202

Human   368 TNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLL 432
            .:..|..|..||.:|.::.:...::|:..::..|..|::||.|.::.::.::..:.::.:|||||
  Fly   203 YSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLL 267

Human   433 LSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNEL 497
            |||||:|||::|:.|:.:...: .|.|||:.:|:|||||:|||.|||:::|..:||:||..||||
  Fly   268 LSVLPKHVAIKMREDLGSSSSE-AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNEL 331

Human   498 FARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMR 562
            |||||:||.:...||||||||||||:||.|:.|.|||..||.||:.|::||..|::.....|:||
  Fly   332 FARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMR 396

Human   563 VGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGE 627
            ||||:|.|..|:||.|:|||||:|.||.|||.||:.|||||:||:..||.:|||::|||...|.:
  Fly   397 VGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEK 461

Human   628 RNAYLKEHSIETFLILR--------CTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHL 684
            |...|:...::|:.|.:        |.:|..|.:|.||..|...:.:
  Fly   462 REELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTT------------------ 508

Human   685 GGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFL-------- 741
              :.||.|.......|.::..||.|.:...::    |.|:.|...::::.|:.::.|
  Fly   509 --DIVSDEDDNDATLDDEELLAQNSVSNGHQI----GIAVTADEEEQVKLENFKQRLKDELVTRD 567

Human   742 ------------LTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYL 794
                        |.|:.|.||:.|:...:......:..|.||..........::|.|  .|.|..
  Fly   568 GHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRS--TLHFIN 630

Human   795 TCSLL--LTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCN 857
            ..:.|  :.::|.:|:..|...:.|.....:|::.........|..:.....:..:..::||.
  Fly   631 IAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFF-- 693

Human   858 SRDLLGCLAQEHNISASQVNACHVAESAVNYSLGD-------------EQGFCGSPWPNCNFPEY 909
               .:..:..||.:|.|:.|.....||.:|..:..             ||.....|.....:|.|
  Fly   694 ---FVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSY 755

Human   910 FTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGT 974
            .:...:|.|:|.:|..|::.:.|::|:|:|..::...      .:|...||
  Fly   756 LSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYF------NIFIMQDL-------------- 800

Human   975 SQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARL 1039
              ::|.::..|:.:.:..|..||                    ::.|..|||...|:.::...|:
  Fly   801 --YALEDDFEHQPIISTRYAASG--------------------LLLVAALALSTLARHMDHEDRV 843

Human  1040 DFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR-NDELYYQSCECVAVMFASIA 1103
            .|.||.:..|:||...:::..|..|::|:||..||.||:...:| :|:||.||...|.|:|||:.
  Fly   844 IFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMP 908

Human  1104 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1168
            |||:||.|...||:|:||||.|||:|:|||.::...:|:.:.||||||||||||||:|      |
  Fly   909 NFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGIN------V 967

Human  1169 GKT------------HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQY 1221
            .:|            |:..|.:||::|...::.|||.|||:|.:|:|:|.||:.|||||||||.|
  Fly   968 QRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHY 1032

Human  1222 DIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1281
            |||||||||||||:|||....||||.:...:|....|....||:|.|||||::||::|.|
  Fly  1033 DIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQG 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	67/284 (24%)
		Guanylate_cyc	460..633	CDD:306677	100/172 (58%)
		DUF1053	668..760	CDD:399378	18/111 (16%)
		Guanylate_cyc	1087..1281	CDD:306677	107/205 (52%)
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	44/161 (27%)
		CYCc	256..453	CDD:214485	112/197 (57%)
		Guanylate_cyc	294..476	CDD:278633	102/181 (56%)
		CYCc	860..1071	CDD:214485	107/216 (50%)
		Guanylate_cyc	892..1092	CDD:278633	107/205 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710