DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ADCY5 and Phlpp

DIOPT Version :9

Sequence 1:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens
Sequence 2:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster


Alignment Length:642 Identity:128/642 - (19%)
Similarity:215/642 - (33%) Gaps:170/642 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   612 NYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGA 676
            |||. ..||   |..|... |...|:.....|:|::.:..|  :|......:|....||      
  Fly    68 NYLT-QLEV---CENEMEV-LDLSSLAQLETLKCSRNKLME--LIINGTNLQTLVADHN------ 119

Human   677 ERPFYNH----LGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLG--RAIDARSIDRLRSE 735
                |.|    ...:.|..:::|:..          |.|...|:..::|  .::.|.:....|..
  Fly   120 ----YLHNISTTNTHPVPLKLQRIDI----------SHNNFSELPNWVGACASLTAINASHNRLN 170

Human   736 HVRKFLLTFREPD---LEKKYS--KQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLT 795
            :|...|..:|..:   |:..|:  ||:|.....:   :|:..|.:...::..:|.:.|.    :|
  Fly   171 NVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGF---SSIRSLQLQSNELPSLPDNFFA----VT 228

Human   796 CSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRD 860
            .:.|.||.|      ||.||...|         |.:.|:.            ||.||:....:..
  Fly   229 HARLETLNV------SCNKLSTLP---------RYEQNNH------------AALVNLSLAGNHL 266

Human   861 LLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNC-----------NFPEYFTYSV 914
            ........||  |:::...|:|.:.:    |.....|...||..           ..||......
  Fly   267 NDSIFEPLHN--AAKLRVLHLAYNRI----GVLPAACVRNWPELEILVLSGNMLQQLPEEVATLG 325

Human   915 LLSLLAC--SVFLQISCIGKLVLMLAIELIY------VLIVEVPG-----VTLFDNADLLVTANA 966
            .|.:|.|  ::.|....:.||.::..::|.:      .|:..||.     :.|..|..|.|....
  Fly   326 QLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQ 390

Human   967 IDFFNNGTSQ-WSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKV---VTP-----IIISVF 1022
            .....:.:.: |||.:...:.|....|.....|..|..::.|.....:   .||     ..:||:
  Fly   391 FKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVY 455

Human  1023 VL----------ALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHF 1077
            .|          |||...:.:|...|       .|.|....:.:|....:      :.||.|   
  Fly   456 QLRAANYGGSDEALYGMFEALEGRGR-------AAQEMSHLVPDLMKQEQ------MVKDSA--- 504

Human  1078 LARERRNDELYYQSCECVAVMFASIANF-------------SEFYVELEANNEGVEC-------- 1121
             .|:.....|.....:|.:|..|::.:.             |:.||...|:..|::.        
  Fly   505 -VRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQ 568

Human  1122 LRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALAD 1178
            |||....:...|:|.|......||.|.:           ||..|..||...:.::.|
  Fly   569 LRLTKPDVIQKDQIHSMPDPHVLELILS-----------NDDEYLVVGNAQLWSVMD 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454
Guanylate_cyc 460..633 CDD:306677 7/20 (35%)
DUF1053 668..760 CDD:399378 20/102 (20%)
Guanylate_cyc 1087..1281 CDD:306677 24/113 (21%)
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 4/20 (20%)
LRR_8 109..169 CDD:290566 12/79 (15%)
leucine-rich repeat 111..135 CDD:275380 6/33 (18%)
leucine-rich repeat 136..158 CDD:275380 5/31 (16%)
leucine-rich repeat 159..183 CDD:275380 5/23 (22%)
leucine-rich repeat 184..209 CDD:275380 6/27 (22%)
LRR_8 205..266 CDD:290566 20/91 (22%)
leucine-rich repeat 210..230 CDD:275380 4/23 (17%)
leucine-rich repeat 232..255 CDD:275380 11/49 (22%)
LRR_RI <256..410 CDD:238064 30/159 (19%)
leucine-rich repeat 256..276 CDD:275380 2/19 (11%)
LRR_8 279..359 CDD:290566 15/83 (18%)
leucine-rich repeat 280..303 CDD:275380 5/26 (19%)
leucine-rich repeat 304..348 CDD:275380 8/43 (19%)
leucine-rich repeat 349..372 CDD:275380 4/22 (18%)
PP2Cc 461..655 CDD:294085 36/182 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.