DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ADCY5 and Gyc32E

DIOPT Version :9

Sequence 1:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens
Sequence 2:NP_001097148.1 Gene:Gyc32E / 34553 FlyBaseID:FBgn0010197 Length:1191 Species:Drosophila melanogaster


Alignment Length:862 Identity:177/862 - (20%)
Similarity:320/862 - (37%) Gaps:268/862 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   541 GMDMIEAISL-VREVTGVNVNMRVG--IHSGRVHCGVLGLRKWQ----FDVW--SND-------- 588
            |:.:.:::.: ||.:|.|   :|:|  |:.|.:....:..|.:.    |||:  ||.        
  Fly   360 GLHLYDSVMIYVRAITEV---LRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTV 421

Human   589 VTLANHMEAGGKAGRIHITKATL-----------------NYLNGDYEV----------EPGCG- 625
            :||.|.:.:|...|  .:.|.::                 .|:..|..:          ||.|| 
  Fly   422 ITLQNDVGSGASIG--SLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGF 484

Human   626 -GERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNP--------------PHWG 675
             ||                .|.:|:.:.:.:::            .|              .|:.
  Fly   485 HGE----------------LCPRKKLDWRYLVS------------GPLCALVVVVAIALLIKHYR 521

Human   676 AERPFYNHLGGNQVSKEMK-----RMG-FEDPKDKN------------AQESANPEDEVDEFLG- 721
            .|:.    |.|.....:||     .:| :.:|.:||            .:.:......:..|.| 
  Fly   522 YEQT----LAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGN 582

Human   722 ----RAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITI 782
                :.|..:|:|..||  :||.|...||...|.                      .|.|:..:.
  Fly   583 IVAMKKIHKKSVDITRS--IRKELKLMREVRHEN----------------------IINFIGAST 623

Human   783 VPHSIFMLSFYLTCSLLLTLV---------VFVSVIYSCV---KLFPSPLQTLSRKIVRSKMNST 835
            ...|:.:.:.|.....|..::         :|:|.:.|.:   .::....:.:|...:||  ::.
  Fly   624 DHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRS--SNC 686

Human   836 LVGVFTITLVFLAAFVNMFTCNSRDL----LGCLAQEHNISASQVN-----ACHVAESAVNYSLG 891
            |:.             :.:.|...|.    |....:|.|.|..::.     |..:...|.....|
  Fly   687 LID-------------SRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRG 738

Human   892 DEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVP-GVTLF 955
            .::|            :.:::.:||          ...||:               :.| |.|.:
  Fly   739 SQKG------------DVYSFGILL----------YEMIGR---------------KGPWGDTAY 766

Human   956 DNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGV---KEQSPE-----HATKVALK 1012
            ...:::......:...:|..:    ..|.|..::...|....:   .::.||     ...::.||
  Fly   767 SKEEIIQFVKCPEMLQHGVFR----PALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLK 827

Human  1013 V----VTPIIISVFVLALYLHAQQVESTA--RLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK 1071
            .    :.|.|....:..:..:|..:|...  |.:.|:     |||::.:       .||:.:||:
  Fly   828 ELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLY-----EEKKKTD-------MLLYQMLPR 880

Human  1072 DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEII 1136
            .||...    :|.|.:..:..:||.::|:.|..|:    ||...:...|.:.:||:.....|.||
  Fly   881 PVAELL----KRGDPVEAECFDCVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSII 937

Human  1137 SEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMD---QMKYINEHSFNNF 1198
            |.   ..:.|::|||..||..|||....    |..|...:|..|:.|::   .:| |........
  Fly   938 SN---YDVYKVETIGDAYMVVSGLPLQN----GSRHAGEIASLALHLLETVGNLK-IRHKPTETV 994

Human  1199 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL-AANTYQLEC 1262
            |::||::.||..|||:|.:.|:|.::|:|||.||||:|||...||.::...||:| ...:|....
  Fly   995 QLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE 1059

Human  1263 RGVVKVKGKGEMMTYFL 1279
            ||:..:||||:|.||:|
  Fly  1060 RGLTSIKGKGDMRTYWL 1076

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454
Guanylate_cyc 460..633 CDD:306677 29/137 (21%)
DUF1053 668..760 CDD:399378 24/128 (19%)
Guanylate_cyc 1087..1281 CDD:306677 68/197 (35%)
Gyc32ENP_001097148.1 PBP1_Speract_GC_like 44..448 CDD:107365 21/92 (23%)
ANF_receptor 59..427 CDD:279440 17/69 (25%)
PHA02988 534..826 CDD:165291 54/371 (15%)
PK_GC-A_B 550..832 CDD:270944 52/361 (14%)
HNOBA <847..886 CDD:285003 13/50 (26%)
CYCc 865..1057 CDD:214485 69/214 (32%)
Guanylate_cyc 892..1076 CDD:278633 67/195 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.