DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCY5 and Ac13E

DIOPT Version :9

Sequence 1:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens
Sequence 2:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster

Alignment Length:	1591	Identity:	373/1591 - (23%)
Similarity:	570/1591 - (35%)	Gaps:	587/1591 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   207 ACCLALLQI---------FRSKKFPSDKLERLYQ---------RYFFRLNQSSLTMLM------- 246
            :||..:|.:         :...||.|..||..||         ||.|.|:...|..||
  Fly    51 SCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILLCSLMWCLYFVV 115

Human   247 ---------------AVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQD 296
                           ::|.||.::.|.|  ....|...:..|.:|...::     ||..:.....
  Fly   116 DGGSEDFWRPISSSFSMLSLVTIMALCF--THWDLYREHRTVTSAVTALL-----LCGASLAFLT 173

Human   297 HMGLACYALIAVVLAVQVVGLL---LPQP--RSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVL 356
            :.|.|...|....:.:::|.|:   ||.|  ..||..|.:::.|          .|.:.::.|
  Fly   174 YTGRAFSPLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAF----------EMVSHMVIG-- 226

Human   357 LSALH-------------LAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAF 408
            .||:|             ..:....:..::.|:.::::::.:    ::|||.......|..|..|
  Fly   227 CSAIHGGPMHGGGGAAGGSGMEANGDPSNRILILRIMAHLSV----HLVGVHVLIMNLVRMRGTF 287

Human   409 QETRECIQARLHSQRENQQQERLLLSVLPRHVA-----------------------MEMKADINA 450
            .:..:.:..|...:.|.|.:|:::.||:|..||                       |..:|..:.
  Fly   288 MKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDV 352

Human   451 KQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKI 515
            |.   :|...::...:|||||||||.|||.::|..||::||..||:||.|||.|.:.:.|.:|..
  Fly   353 KS---LFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKIST 414

Human   516 LGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW 580
            ||||||||||.||.|||||.||||||:.||:|:..........|.||||:|:|.|.||::|.|:.
  Fly   415 LGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRV 479

Human   581 QFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG----------CGGERNAYLKEH 635
            :||||||||:|||.||:.||..::||::.|.::|...|.:|.|          ..|.|..:.:.:
  Fly   480 KFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYLEEGEEVFGHRTYFVVGRRRDFTRTN 544

Human   636 SIETFLILRCTQKRKEEKAMI------AKMNRQRTN-----------------SIGHNPPHWGAE 677
            |:...:....|     ..:::      |.:::..||                 |...||....:.
  Fly   545 SLSPSMPANAT-----GSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSM 604

Human   678 RPFYNHLGGNQVSKEMKR-------------MGF-------EDPK------------DKNAQ--- 707
            ||....|......|...|             .|.       |.||            |.:.|
  Fly   605 RPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPV 669

Human   708 -----ESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF----------------------- 744
                 ..|||.         |.:.||..:|:...:.:||..|
  Fly   670 SPPLLPPANPP---------AAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKERE 725

Human   745 REPDLEKKYSKQ------------VDDRFGAYVACASLVFLFICFVQITI------------VPH 785
            ||.:.||:...|            :|::......|.        :.|:.:            :|.
  Fly   726 REREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCG--------YQQLPVLVESNHRTQTLDIPA 782

Human   786 SIFMLSFYLTCSLLLTLVV------------------------------FVSVIYSCVKLF---- 816
            :..:|....|.:.|.:.|:                              ::|...|.:..|
  Fly   783 ARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSG 847

Human   817 -------------------------------------------------------------PSPL 820
                                                                         |.|.
  Fly   848 SYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPS 912

Human   821 QT--------------------------------LSRKIVRSKMNS------------------- 834
            .|                                .|||....|.||
  Fly   913 STSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQ 977

Human   835 -TLVGVFTITLVFLAAF-----------------VNMFTCNSR---DLLGCLAQEHNISASQVNA 878
             .:.|.||.:...::..                 :.|..|:|:   .|..||.|....|..|:..
  Fly   978 HRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIR 1042

Human   879 CHVAESAVN------------YSL------------------GDEQGFCGSPWPNCNFPEYFTY- 912
            | |.::|.:            :||                  |.|....|.  |....|.|.||
  Fly  1043 C-VRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGP--PTLATPRYNTYI 1104

Human   913 ------------SVLL----------------SLLACSVFLQI---------------------- 927
                        ||.|                :|.:|...:|:
  Fly  1105 DIFVGIAVYLCISVSLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNR 1169

Human   928 ---------------------------SCIGKL----------------------------VLML 937
                                       ||..::                            .|:|
  Fly  1170 FRSKSTTSEDLERDERGAAPGGRPHFESCADRIFEAISSWYPWHICLAVLMAMPVLLIIANFLLL 1234

Human   938 AIE-----------LIYVLIVEVPGVTLFD--NADLLVTANAIDFFNNGTSQWSLCENLR--HRR 987
            .:|           ||:|.||.....|..:  ..::|....|:.|.....||..:..:.|  .::
  Fly  1235 DLEQLEAFEYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQLMVYSHNRSDQQQ 1299

Human   988 MEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKE 1052
            .:..:.|...:|.....|     :::...::: :.||..:|: ::.|...||.|.....|.::|.
  Fly  1300 DQEASNFIQEIKWFQDYH-----VEIYLDLLL-ILVLVWFLN-REFEIGYRLTFYGNAVANQDKV 1357

Human  1053 EMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE 1117
            .::.::.....|||||:||.||.|.     :|...|.::...:|::||||.||:|.|.|....
  Fly  1358 RVQNMKNQADMLLHNIIPKHVAEHL-----KNTAKYSENHHNIAIIFASIVNFNEMYDESYLG-- 1415

Human  1118 GVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMK 1182
            |.|.||:|||:|.||||::|...||.:|||||||||:|||||| |.::...|..||..|.:|::.
  Fly  1416 GKEFLRVLNELIGDFDELLSRPEFRAVEKIKTIGSTFMAASGL-DPSHRGTGDEHIHTLMEFSIA 1479

Human  1183 LMDQMKYINEHSFN-NFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT 1246
            :.:.:...|:.... |..::||:|||.|.|||||..|..|||||:.|||||||||||:|:||||.
  Fly  1480 MQEVVDAFNKDLLEFNLILRIGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVG 1544

Human  1247 TDMYQVLAANTYQLECRGVVKVKGKGEMMTY 1277
            .|....| .|.|:.|.||.|.||||..|..:
  Fly  1545 KDCLPFL-TNRYEFEPRGSVYVKGKDHMEVF 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	63/331 (19%)
		Guanylate_cyc	460..633	CDD:306677	89/182 (49%)
		DUF1053	668..760	CDD:399378	29/166 (17%)
		Guanylate_cyc	1087..1281	CDD:306677	95/192 (49%)
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	96/218 (44%)
		Guanylate_cyc	361..535	CDD:278633	87/173 (50%)
		CYCc	1362..1556	CDD:214485	96/202 (48%)
		Guanylate_cyc	1388..1575	CDD:278633	95/191 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810