DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ADCY5 and rut

DIOPT Version :9

Sequence 1:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens
Sequence 2:NP_511156.2 Gene:rut / 32406 FlyBaseID:FBgn0003301 Length:2248 Species:Drosophila melanogaster


Alignment Length:1231 Identity:467/1231 - (37%)
Similarity:671/1231 - (54%) Gaps:267/1231 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   220 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLA----------FHAARPPLQLPYLAVL 274
            :|.:|:||.|||||..:|.:.|:..::|::.::|.||.|          ||..       :.|::
  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNI-------FNAIV 74

Human   275 AAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVV-----GLLLP--QPRSASEGIWWT 332
            .....|:|:: :.|:....|  |:...||.::....::.||     |.:.|  .....:||:|..
  Fly    75 CGLFAVVLVL-LQCSVIKDH--HLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQI 136

Human   333 VFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIA---LRTNAQDQFLLKQLVSNVLIFSCTNIVGV 394
            ||.::..|.::|:::..||..|:.|.::|:::.   :.|:|.......||::|::||...|:.|:
  Fly   137 VFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGL 201

Human   395 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHK 459
            ..:...|.:||:.|.:||.||.:||..|.||::.|||||||||:||||:||.||.:.... .||:
  Fly   202 VVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHR 265

Human   460 IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVS 524
            ||||||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||
  Fly   266 IYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVS 330

Human   525 GLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDV 589
            ||||.|.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.||||||||||||||||||
  Fly   331 GLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDV 395

Human   590 TLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKE--- 651
            |||||||:||:.||:|:|:|||:.|:|:||||.|.|.||::||::|.::||.|:....:||.   
  Fly   396 TLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLML 460

Human   652 -----EKAM----------IAKMNRQRTNSIGHNPPHWGAERPFYN-----------HLGGN--- 687
                 ..|:          ::.:..|..::|..:.|     .||.|           .|||.   
  Fly   461 NTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEP-----VPFSNIATGSFPSAASALGGGVSV 520

Human   688 ------------------------QVSKEMKR-----------------MGF------------- 698
                                    |||::..|                 ||:             
  Fly   521 GGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSG 585

Human   699 --------------------------------------EDPKDKNAQESA--------------- 710
                                                  .:.|:..:|...               
  Fly   586 ISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVA 650

Human   711 ---NPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVF 772
               .|.:.|:.||.:||:|||:|..:||||.:..|.||:.|:|::|.|..|..|...:.|:.|:.
  Fly   651 AHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLL 715

Human   773 LFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLV 837
            :....:|:|.:|.::.:        |||.|..|:.|....:.|....|:.:...|..|......:
  Fly   716 ILGAALQVTALPRTLIL--------LLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAI 772

Human   838 GVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWP 902
            .:||:.|::....||:|||.|         :|..|.:...:                 |......
  Fly   773 TIFTVILIYSVGQVNVFTCVS---------DHPCSGNGTTS-----------------FQNDSHR 811

Human   903 NCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAI 967
            .|:.|:|.:.|...:.|:.||||::..|.|.:|:|.:..||.|.:|:....:|:..|..|.|:  
  Fly   812 KCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS-- 874

Human   968 DFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQ 1032
                                                     :.|.:::...|::|::|:.:|.:.
  Fly   875 -----------------------------------------IPLHLISLARIAIFMIAILVHGRL 898

Human  1033 VESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVA 1096
            ||.||||||||:|||::||:||:.||..|:|:|||:||..|||||| |:.|.|.|||:||...|.
  Fly   899 VEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVG 963

Human  1097 VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL- 1160
            |:|||:.||:|||.|::.:::|:|||||||||||||||::.|||||.::||||:||||||..|| 
  Fly   964 VIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLI 1028

Human  1161 -------NDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARK 1218
                   ||.  :.| :.|:.||.::...:...::.||.||:|||.:::|:||||||||||||||
  Fly  1029 PEYKIQPNDP--NSV-RRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARK 1090

Human  1219 PQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFL 1279
            ||||||||||||||||||||||...|||.::...|..:.::..|||.:||||||:|:||||
  Fly  1091 PQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454 81/257 (32%)
Guanylate_cyc 460..633 CDD:306677 131/172 (76%)
DUF1053 668..760 CDD:399378 37/215 (17%)
Guanylate_cyc 1087..1281 CDD:306677 116/201 (58%)
rutNP_511156.2 AC_N <17..255 CDD:292831 79/247 (32%)
CYCc 230..425 CDD:214485 143/195 (73%)
Guanylate_cyc 266..438 CDD:278633 130/171 (76%)
DUF1053 624..696 CDD:283888 21/71 (30%)
SLC5-6-like_sbd <742..>893 CDD:294310 42/219 (19%)
CYCc 924..1134 CDD:214485 120/212 (57%)
Guanylate_cyc 954..1151 CDD:278633 114/199 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.710

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