Protein Alignment ADCY5 and CG32305

DIOPT Version :9

• Sequence 1: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Alignment Length: 1162
• Identity: 297/1162 - (25%)
• Similarity: 511/1162 - (43%)
• Gaps: 253/1162 - (21%)

Human   242 LTMLMAVLVLVCLV---MLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACY 303
            |.|:..|::|:.||   :|.       ..:||.||:..:..::|:..         |:::|:...
  Fly    63 LLMVAHVILLLALVKDIILV-------TMVPYFAVMLFSPFIMLLSM---------QNNVGMITN 111

Human   304 ALIAVVLAVQVVGLLLPQPRSA---SEGIWWTV-----FFIYTIYTLLPVRM---RAAVLSGVLL 357
            .||:.::|:.:..:.|......   |...:.||     ..:.::|..||:..   .:..:.|:::
  Fly   112 TLISWLMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVYMTLPIAFYQGSSVYVLGMVV 176

Human   358 SALHLAIAL---RTNAQDQFLLK-----QLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETREC 414
            |.:::..|.   ..|.|..|.|.     .|.:..||||...|:       .:...|:|.....:.
  Fly   177 SIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTII-------RDYGLRRAILSRYQL 234

Human   415 IQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDM---------MFHKIYIQKHDNVSI 470
            :...:..|...:::..||.|:|||.:...::.:|.::.||.         ...|::::.:.||||
  Fly   235 VYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSI 299

Human   471 LFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
            |.||:..:|.|.:...|.:||..|::||..||..|..|..:|||.|||.|.||:|:|.....||.
  Fly   300 LVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHAS 364

Human   536 CCVEMGMDMI---EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 597
            |||:..::||   :.:|..||   :::|:|:|:|||.|..|::|..|||||:||.||.:.|.:|:
  Fly   365 CCVDQALEMIHITQGVSSRRE---LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLES 426

Human   598 GGKAGRIHITKATLNYLNGDYEVEPGCGGERN-AYLKEHSIETFLILRCTQKRKEEKAMIAKMNR 661
            .|..|.:|:::.||:.|:..|....|....:| ..|::..|.|||:........|...:..:::.
  Fly   427 SGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGELDDELSS 491

Human   662 QRTNSIGHNPPHWGAERPFYNHL---GGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRA 723
            ...||...:   :|.   :|..:   ...::.||:.:|.......:..:.|:..:.:.:|
  Fly   492 ASINSCRLS---YGG---YYEEIQIKAQREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNE----- 545

Human   724 IDARSIDRLRSEHVRKFLLTFRE----------PDLEKKYSKQVDDRFGAYVACASLVFLFICFV 778
                  :.|.|..:...|..||.          |||..||:..:       |.||.|..:.|..:
  Fly   546 ------EYLFSNQIHLVLGVFRSWKREWEFHNLPDLMIKYTMLL-------VLCAGLAIMSINLI 597

Human   779 QITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFP--SPLQTLSRKIVR--SKMNSTLVGV 839
            :....|..:.:|...|...:|..|..:..:.....||.|  .|...|||.::|  .::..:|...
  Fly   598 EEATYPDILVLLGILLILLILCILAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVR 662

Human   840 FTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAE---SAVNYSLGDEQGF--CGS 899
            ..:|:|.|.....|                  |:..|.:|.||:   |.:...|.:|:.:  |..
  Fly   663 IPLTMVVLLLLYVM------------------SSQAVFSCDVAKLELSIIEAHLYNEKSYAECFG 709

Human   900 PWPNCNFPEYFTYSV--LLSLL----ACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNA 958
            ||.       .||.|  ::|||    .|.:.::| ..|.|:|.|.:..:::..
  Fly   710 PWT-------VTYCVVIVISLLFVVPGCPLVIKI-LAGLLILGLHLGTVHLYY------------ 754

Human   959 DLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFV 1023
                   ...|..:.|:...|..:..|      |::                       ::::|:
  Fly   755 -------GFAFERSETTDLGLKSDYAH------TWY-----------------------LVALFI 783

Human  1024 LALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELY 1088
            : |.|..:.|....:.::..::...|..::.:|.....:.::.||||..||..:..| |.:|:||
  Fly   784 V-LVLRERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVR-RPHDQLY 846

Human  1089 YQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFR-QLEKIKTIGS 1152
            |::...||||||||.||:       |:..|   ||:|:|||..||:::.:.:.| ::||||.:|.
  Fly   847 YENFSKVAVMFASIENFN-------ADTAG---LRILHEIICCFDDLLVDYQTRYKIEKIKVMGW 901

Human  1153 TYMAASGLNDSTY---------------------------------------DKVGKTH------ 1172
            |||.|.||....|                                       |.|.:.:
  Fly   902 TYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDV 966

Human  1173 -IKALADFA---MKLMDQMKY---INEH-SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVN 1229
             :..:.:||   :::|..::|   .:|: :|....:|||::.|.|:|||:|..||.|||||:|||
  Fly   967 AVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVN 1031

Human  1230 VASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS 1286
            :||||.|||:.|.||||....:||.....:...||..:|||.|::.||.:...|.|:
  Fly  1032 MASRMSSTGLLDNIQVTRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLVVVDPDLT 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	49/246 (20%)
		Guanylate_cyc	460..633	CDD:306677	69/176 (39%)
		DUF1053	668..760	CDD:399378	17/104 (16%)
		Guanylate_cyc	1087..1281	CDD:306677	85/247 (34%)
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/200 (39%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	66/155 (43%)
		CYCc	814..1056	CDD:214485	86/252 (34%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	85/245 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910