DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADAMTS8 and AdamTS-B

DIOPT Version :9

Sequence 1:	NP_008968.4	Gene:	ADAMTS8 / 11095	HGNCID:	224	Length:	889	Species:	Homo sapiens
Sequence 2:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	1072	Identity:	321/1072 - (29%)
Similarity:	468/1072 - (43%)	Gaps:	259/1072 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     9 RWPPLLLLLLLLLPLARGAPARPAAGGQASE-------LVVPTRL-------------------- 46
            ||..|||...|:: :.:|...||..|..:.|       ||||.|:
  Fly    11 RWLGLLLHYWLVV-VTQGGGVRPLYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHR 74

Human    47 ------------PGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLR- 98
                        ...|.:|.|.|....:...|.|.....||||...:||         ..|.||
  Fly    75 RHRQRRSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVER---------HRRDLRT 130

Human    99 ---------GCFFSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTI------QPQGAGG------ 142
                     .|.|.|.|.|:|.:..|:|.|.||.|.....|.|:.|      :|....|
  Fly   131 RSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVF 195

Human   143 ---------SLAQPHRLQRWGPAGA-------------RPLPRGPEWE------VETGEGQRQER 179
                     ||.:.::.:|.|.:|:             |.:....||:      |:.|...|:..
  Fly   196 QRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHH 260

Human   180 GDHQEDSEEESQEEEAEGASEPP-------------PPLGATSRTKRFVSEARFVETLLVADASM 231
            ..|.....:.......:..|..|             |......|.:|.:|..|.||||:||||:|
  Fly   261 HHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATM 325

Human   232 AAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPE--VSDNGGLTLRNFC 294
            :||: .||..::||:|::.:.:||.|||.|||.::||:::.:::|:...:  ::.|....|..||
  Fly   326 SAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFC 389

Human   295 NWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAH 359
            :||.:.|:.|::.|.|:|.|||:||:|.|...  |.|||:|::|.:|.|.:||||.||.|:..:|
  Fly   390 SWQHKLNKGSEKDPHHHDVAILITRKNICANN--CMTLGLANVGGMCKPKQSCSVNEDNGIMLSH 452

Human   360 TLAHELGHVLSMPHDDSK-PCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGD 423
            |:.|||||...|.||.:| .|....||:  .|:|.|.|......:.||.||..|:|..||.|.|:
  Fly   453 TITHELGHNFGMFHDTAKIGCHPRVGPI--VHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGE 515

Human   424 CLLDAPAAALPLP----TG-LPGRMALYQLDQQCRQIFG----PDFRHCPNTSAQDVCAQLWCHT 479
            ||.|.|.   ||.    || |||..  |....|||..|.    .:...|  ::..:.|:.|||..
  Fly   516 CLDDPPT---PLDEYNYTGELPGMR--YNARGQCRLQFNLTTDSEVGAC--SAPHEFCSTLWCKV 573

Human   480 DGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGG 544
            :| |.:.|.:    |.|.||.||....|..|.|:..||:    ...:|||..|..|.||||:|||
  Fly   574 NG-ECVTHMR----PTAPGTLCGRNKWCQNGKCVRREEL----AAVNGGWGDWSEWSECSRSCGG 629

Human   545 GVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQ 609
            ||....|||.:|.|.|||.:|:|.|.:|:.|....||.:..|||.|||.:::..:|   .|...:
  Fly   630 GVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSY---QGATYK 691

Human   610 WVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPR 674
            |:|.:...:|   |||||.....:....:.|.|:|||.|...|..:|:.|.|.|.|||.:|||..
  Fly   692 WLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEV 753

Human   675 KLDKCGVCGGKGNSCRKVSGSLT----PTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLAL 735
            :.|:||||||.|:.|:.|..:.|    ..:..|.:||||||.|.:|.:::     :.|..::||:
  Fly   754 QDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAI 813

Human   736 KTADG--QYLLNGNLAISAIEQDILVKGTILKYSGSIATLERL--QSFRPLPEPL--TVQLLT-V 793
            .|.||  ::.|||:..||...:        .:.:|:.:..:|:  |....:|:|:  ::.|.. |
  Fly   814 ATGDGGDRFYLNGDSLISMPGE--------FEIAGAESLYDRVDEQETITIPQPIQHSISLYAIV 870

Human   794 PGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAG------- 851
            .|......:.|.|.:|     ::..:..|          ..||.|.:|:.||::||.|
  Fly   871 RGNESNAGIFYEFTLP-----ALNVTAGR----------QFQWRLSNWTACSASCGGGVQHREPI 920

Human   852 -------------------------------------------WQ-----------------RRT 856
                                                       ||                 ||:
  Fly   921 CQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRS 985

Human   857 VECRDPSG--QASATCNKALKPEDAKPCESQL 886
            |.|.|...  .|.|.|....||.:.:||||.|
  Fly   986 VVCLDEHDVVVADAECGHLQKPAEMEPCESSL 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADAMTS8	NP_008968.4	Pep_M12B_propep	50..150	CDD:279848	34/130 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..210		16/118 (14%)
		Reprolysin	219..429	CDD:279729	92/212 (43%)
		ZnMc_ADAMTS_like	219..426	CDD:239801	90/209 (43%)
		ADAM_CR	448..514	CDD:301627	21/69 (30%)
		TSP1	529..581	CDD:214559	25/51 (49%)
		Spacer	690..831		34/151 (23%)
		ADAM_spacer1	690..809	CDD:283607	32/129 (25%)
		TSP1	836..888	CDD:214559	25/120 (21%)
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	32/124 (26%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	89/208 (43%)
		Reprolysin	315..521	CDD:279729	91/210 (43%)
		ADAM_CR	<558..602	CDD:301627	16/50 (32%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAM_spacer1	773..886	CDD:283607	31/125 (25%)
		TSP1	901..956	CDD:214559	6/54 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720