DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADAMTS13 and nolo

DIOPT Version :9

Sequence 1:	NP_620594.1	Gene:	ADAMTS13 / 11093	HGNCID:	1366	Length:	1427	Species:	Homo sapiens
Sequence 2:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster

Alignment Length:	1197	Identity:	255/1197 - (21%)
Similarity:	373/1197 - (31%)	Gaps:	457/1197 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQ 449
            |:||||...|.|||:|.||::.:.|:|.:|      .:|.|...:..:||.|.|.:.| :|.|.|
  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQQ-DFRSSQ 133

Human   450 CARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRA----IGESFIMKRGDS--------- 501
            |:..:..|.     ..:.|.|   .||......|...||.    :.|....:.||.
  Fly   134 CSAYNDVPY-----DGTLYKW---TPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYD 190

Human   502 -----------FLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 555
                       ..|||||      ..|:|.:|:.|.|:..|||.::.|.:..|.|.|||||.::|
  Fly   191 EQSVIVQLSARVQDGTRC------RSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC 249

Human   556 SPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSL 620
            |                                :|||.
  Fly   250 S--------------------------------QPLFN--------------------------- 255

Human   621 LEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQA 685

  Fly   256 ----------------------------------------------------------------- 255

Human   686 WVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGD 750
            |..|.: ..|||:||:|.:.....|.::.....|:...|..:.:|.|..|.|....|||.|...|
  Fly   256 WEMAPM-SQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADD 319

Human   751 FGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
            :..||..||.|.|||.|.|.|....:...:....||  ..:|... |||..:.|| .|||.:.:.
  Fly   320 WSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCR--TPKPPTQ-ETCIIEECP-HWEVEDWTG 380

Human   816 CTSAGGAGLALENETCVPGADGLEA---PVTEGPGSVDEKLPAPEPC-VGMSC------------ 864
            |:.:.|.|:.:....|......|.|   |:|: |||:.:       | .|:.|
  Fly   381 CSVSCGQGIQMRGVECKSTDGSLSAKCDPLTK-PGSMQQ-------CSTGIHCGGSLNKVGGTII 437

Human   865 ------------------------------------------------------PPGWGHLDATS 875
                                                                  |..:.|...:.
  Fly   438 VGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSR 502

Human   876 AGEKAP-----------------------SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 917
            ..::||                       |...|:.......:.|:|    |||:||.|:....:
  Fly   503 LNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSP----CSVTCGEGIRRRTY 563

Human   918 LCM----DSALRVPVQEELCGLASKPGSRREVCQAVPC----------------------PAR-- 954
            .|.    .|.....|.:.||. ..||....|.|...||                      |.:
  Fly   564 NCKIFLEYSRTVATVNDSLCE-GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTY 627

Human   955 -WQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCPPRW 1016
             |:.: ..:||.||..||...|:.|.|   ||:| .::....|....:||.: ..|:..||||||
  Fly   628 VWREQGYTSCSASCLGGVEELIINCVR---EDNG-RVVSPFLCSPETKPEARVRTCNDRPCPPRW 688

Human  1017 KVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVP---------CLIADC 1072
            ......|||.|||:|...|.|.|:.       ||.......:|.|.:..|         |.:.||
  Fly   689 NYSDYTPCSKSCGIGIKTREVQCIH-------EVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDC 746

Human  1073 TYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQAPVPADFCQHLPKPVTVRGCWAGPC---- 1130
            ..||.||.|.:||.:||.|.:.|:..|   :..:.:...|...|.. .||...:.|...||
  Fly   747 PVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPS-AKPADKKPCNVKPCPPED 810

Human  1131 ----VGQGTPSLVPHEEAAAPGRT--TATPAGASL---------------------EWSQARGLL 1168
                :.....:.:.|:    |.:|  |....||.|                     :||:..
  Fly   811 PKPVIQINNSTHIQHD----PKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDH--- 868

Human  1169 FSPAPQPR----------RLL----------------------------PGPQENSVQSSACGRQ 1195
             .|..:.|          |:|                            ||.|...::.....|.
  Fly   869 -KPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERL 932

Human  1196 HLEPTGT-----IDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCR 1255
            ..|.:||     .||:.......:.|:|.           .|.:|.||..    .|....::...
  Fly   933 VREKSGTEALTSADMKSADGTGTSTAVGP-----------NSHVNGSAQQ----HGSRRRQQQSE 982

Human  1256 KLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1320
            :|.:           .|:|..||...     |.|.|..:...:...||......|.    .||::
  Fly   983 RLQN-----------GRERSRRPKSD-----GVQHADSSIMEDDLSQLVQSEDRIP----QPASA 1027

Human  1321 NAGGCRLFINVA-PHARIAIHALATNM 1346
            ::||.|....:| |:    ..||.:|:
  Fly  1028 SSGGSRTRTLLAMPY----FQALLSNL 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADAMTS13	NP_620594.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..70
		ZnMc_ADAMTS_like	80..283	CDD:239801
		TSP1	387..439	CDD:214559	19/51 (37%)
		Cysteine-rich	440..556		37/139 (27%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Spacer	556..685		4/128 (3%)
		ADAM_spacer1	559..680	CDD:283607	3/120 (3%)
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	19/51 (37%)
		TSP1	546..600	CDD:214559	17/58 (29%)
		TSP1	750..807	CDD:214559	17/57 (30%)
		IGc2	845..902	CDD:197706	6/60 (10%)
		PLAC	1355..1384	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810