Protein Alignment WDR5 and SWD3

DIOPT Version :10

• Sequence 1: NP_060058.1
• Gene: WDR5 / 11091
• HGNCID: 12757
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_009734.1
• Gene: SWD3 / 852472
• SGDID: S000000379
• Length: 315
• Species: Saccharomyces cerevisiae
• Alignment Length: 326
• Identity: 113/326 - (34%)
• Similarity: 164/326 - (50%)
• Gaps: 41/326 - (12%)

Human    29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-----GHKL 88
            |||.....||.|.|         |.||:|::||.:....::    .||.. .:|:|     .|..
Yeast     6 TPVGTQNGLKATCA---------KISPDGQFLAITQGLNIL----IYDIN-RRTVSQTLVTSHAR 56

Human    89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
            ..|::.||.|...:.:||||.:::|..:|.| .|.|..||:..|....||.:.||:.:.|.|||:
Yeast    57 PFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 120

Human   154 RIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--- 214
            :|||...|..:||:.|||:.|.:|.. ..|.|::.|.|||||.||:|..:|.|||||..|.:
Yeast   121 KIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185

Human   215 ----PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI-------FANFSV 268
                .|:|.||||.|.:|:|..:||..:|:||...|..::|:.....||..:       |.|...
Yeast   186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250

Human   269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG----HTDVVISTACHPTENIIASAALENDKTIKL 329
            .....::||.|:..:|.||..||.::|.|.|    |:..|:|..|.  .||:.|.||..|..:..
Yeast   251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCCLWR 313

Human   330 W 330
            |
Yeast   314 W 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR5	NP_060058.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		1/1 (100%)
		WD40	<36..330	CDD:441893	109/317 (34%)
		WD 1	43..82		8/38 (21%)
		WD40 repeat	48..85	CDD:293791	10/41 (24%)
		WD 2	85..126		14/40 (35%)
		WD40 repeat	91..127	CDD:293791	13/35 (37%)
		WD 3	128..168		16/39 (41%)
		WD40 repeat	132..168	CDD:293791	15/35 (43%)
		WD 4	169..208		19/39 (49%)
		WD40 repeat	175..210	CDD:293791	17/35 (49%)
		WD 5	212..253		17/47 (36%)
		WD40 repeat	217..253	CDD:293791	15/35 (43%)
		WD 6	256..296		12/46 (26%)
		WD40 repeat	261..298	CDD:293791	11/43 (26%)
		WD 7	299..333		12/36 (33%)
		WD40 repeat	304..330	CDD:293791	9/25 (36%)
SWD3	NP_009734.1	WD40 repeat	17..53	CDD:293791	12/49 (24%)
		WD40	<21..293	CDD:441893	96/277 (35%)
		WD40 repeat	59..94	CDD:293791	13/35 (37%)
		WD40 repeat	99..135	CDD:293791	15/35 (43%)
		WD40 repeat	142..178	CDD:293791	17/35 (49%)
		WD40 repeat	192..228	CDD:293791	15/35 (43%)
		WD40 repeat	236..284	CDD:293791	13/47 (28%)
		WD40 repeat	290..312	CDD:293791	9/23 (39%)