Protein Alignment WDR5 and Lis-1

DIOPT Version :10

• Sequence 1: NP_060058.1
• Gene: WDR5 / 11091
• HGNCID: 12757
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_477160.1
• Gene: Lis-1 / 36791
• FlyBaseID: FBgn0015754
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 354
• Identity: 107/354 - (30%)
• Similarity: 178/354 - (50%)
• Gaps: 33/354 - (9%)

Human     1 MATEEKKPETEAARAQPTPSSSATQSKPTPVK--PNYALKFTLAGHTKAVSSVKFSPNGEWLASS 63
            |..|.|..|.|....:..|    |::|.||.:  |....||:|.||..:::.|.|.|....:.|:
  Fly    66 MELEAKLTEAEKEVIEGAP----TKNKRTPGEWIPRPPEKFSLTGHRASITRVIFHPIFALMVSA 126

Human    64 SADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV-SSGKCLKTLKG 127
            |.|..|:||....|::|:::.||...:.|||:.:...||.|.|.|.::|:||. .|.:|:||:.|
  Fly   127 SEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHG 191

Human   128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
            |.:.|....|.|..:.::|.|.|.::::|:|.||.|:||...|.:.|..|..:.:||:..:.|.|
  Fly   192 HDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSND 256

Human   193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP--------------------NGKYILAATLDNT 237
            ...|:|.|.|..| |..:.|....|..:.::|                    .|.::.:.:.|.|
  Fly   257 QTIRVWLTNSKDC-KVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT 320

Human   238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302
            :::||.|.|.||.|.:||.|....:..:   .|||::||.|:|..:.:|:|:.|..::.|..|..
  Fly   321 IRIWDVSVGLCLLTLSGHDNWVRGLAFH---PGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQH 382

Human   303 VVISTACHPTENIIASAALENDKTIKLWK 331
            ...|...|.....:.|.::  |:|:|:|:
  Fly   383 FCTSIDFHKAHPYVISGSV--DQTVKVWE 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR5	NP_060058.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		9/29 (31%)
		WD40	<36..330	CDD:441893	95/314 (30%)
		WD 1	43..82		13/38 (34%)
		WD40 repeat	48..85	CDD:293791	11/36 (31%)
		WD 2	85..126		17/41 (41%)
		WD40 repeat	91..127	CDD:293791	15/36 (42%)
		WD 3	128..168		14/39 (36%)
		WD40 repeat	132..168	CDD:293791	13/35 (37%)
		WD 4	169..208		12/38 (32%)
		WD40 repeat	175..210	CDD:293791	11/34 (32%)
		WD 5	212..253		13/60 (22%)
		WD40 repeat	217..253	CDD:293791	12/55 (22%)
		WD 6	256..296		11/39 (28%)
		WD40 repeat	261..298	CDD:293791	10/36 (28%)
		WD 7	299..333		8/33 (24%)
		WD40 repeat	304..330	CDD:293791	6/25 (24%)
Lis-1	NP_477160.1	LisH	9..40	CDD:128913
		WD40	100..409	CDD:238121	95/314 (30%)
		WD40 repeat	111..148	CDD:293791	11/36 (31%)
		WD40 repeat	154..191	CDD:293791	15/36 (42%)
		WD40 repeat	196..232	CDD:293791	13/35 (37%)
		WD40 repeat	239..274	CDD:293791	11/35 (31%)
		WD40 repeat	280..336	CDD:293791	12/55 (22%)
		WD40 repeat	342..378	CDD:293791	10/38 (26%)
		WD40 repeat	384..408	CDD:293791	6/25 (24%)