Protein Alignment WDR5 and wdr-5.1

DIOPT Version :10

• Sequence 1: NP_060058.1
• Gene: WDR5 / 11091
• HGNCID: 12757
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_497749.1
• Gene: wdr-5.1 / 175474
• WormBaseID: WBGene00006474
• Length: 376
• Species: Caenorhabditis elegans
• Alignment Length: 339
• Identity: 225/339 - (66%)
• Similarity: 268/339 - (79%)
• Gaps: 13/339 - (3%)

Human     8 PETEAARAQP-----TPSSSATQSKPTP--------VKPNYALKFTLAGHTKAVSSVKFSPNGEW 59
            |.|......|     ||:..|:...|.|        ...||.|..||.||||::||.||||.|::
 Worm    37 PSTSPNSISPSNPTGTPAPGASAQTPNPNAAGASASGSANYKLMCTLEGHTKSISSAKFSPCGKY 101

Human    60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT 124
            |.:|||||.:|||.......|:|::|||||::|:||||||..:|||||||||||:::.:.:..||
 Worm   102 LGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKT 166

Human   125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189
            ||||:||||||||||||:|:|||||||||||||||||.|:|||||||||||||.||||||||.|.
 Worm   167 LKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASG 231

Human   190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
            |||||.||||||:|||:|||:||:||||:|||||||||||||:.||:||||||:||||.||.|||
 Worm   232 SYDGLVRIWDTANGQCIKTLVDDENPPVAFVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTG 296

Human   255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319
            |:|.||||||||||||||||:|||||..:|||||||:||||.|:|||..|:::.|||.:|||||.
 Worm   297 HENSKYCIFANFSVTGGKWIISGSEDCKIYIWNLQTREIVQCLEGHTQPVLASDCHPVQNIIASG 361

Human   320 ALENDKTIKLWKSD 333
            |||.|..|.:|:||
 Worm   362 ALEPDNKIHIWRSD 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR5	NP_060058.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		8/35 (23%)
		WD40	<36..330	CDD:441893	212/293 (72%)
		WD 1	43..82		21/38 (55%)
		WD40 repeat	48..85	CDD:293791	18/36 (50%)
		WD 2	85..126		25/40 (63%)
		WD40 repeat	91..127	CDD:293791	21/35 (60%)
		WD 3	128..168		34/39 (87%)
		WD40 repeat	132..168	CDD:293791	31/35 (89%)
		WD 4	169..208		32/38 (84%)
		WD40 repeat	175..210	CDD:293791	28/34 (82%)
		WD 5	212..253		32/40 (80%)
		WD40 repeat	217..253	CDD:293791	28/35 (80%)
		WD 6	256..296		32/39 (82%)
		WD40 repeat	261..298	CDD:293791	30/36 (83%)
		WD 7	299..333		18/33 (55%)
		WD40 repeat	304..330	CDD:293791	14/25 (56%)
wdr-5.1	NP_497749.1	PRK13914	<2..>96	CDD:237555	20/58 (34%)
		WD40	79..373	CDD:238121	212/293 (72%)
		WD40 repeat	90..127	CDD:293791	18/36 (50%)
		WD40 repeat	133..169	CDD:293791	21/35 (60%)
		WD40 repeat	174..210	CDD:293791	31/35 (89%)
		WD40 repeat	217..252	CDD:293791	28/34 (82%)
		WD40 repeat	259..295	CDD:293791	28/35 (80%)
		WD40 repeat	303..340	CDD:293791	30/36 (83%)
		WD40 repeat	346..372	CDD:293791	14/25 (56%)