DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIDO1 and pps

DIOPT Version :9

Sequence 1:	XP_011526806.1	Gene:	DIDO1 / 11083	HGNCID:	2680	Length:	2276	Species:	Homo sapiens
Sequence 2:	NP_001247075.1	Gene:	pps / 41524	FlyBaseID:	FBgn0082831	Length:	2018	Species:	Drosophila melanogaster

Alignment Length:	1799	Identity:	406/1799 - (22%)
Similarity:	623/1799 - (34%)	Gaps:	562/1799 - (31%)

- Green bases have known domain annotations that are detailed below.

Human     8 SNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLE------PPPPQQQLG-------- 58
            ::|:.||.:|.....                 |.|.:..|:.      |.|..|.:|
  Fly   639 ADEDIPKLVKMLEST-----------------AADLDPPPVSLPTNIFPAPEMQGVGNAAAADPN 686

Human    59 -------------------LSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPA 104
                               :.|....:| ...|.|:|.|. :...|.....||:..|.||...|.
  Fly   687 NIMDTANEDEITADFLQHVVGLIEEDKQ-FEAEVVKQVLA-STEPGTLDAIVSMPTSIEPVDVPQ 749

Human   105 TDAET---ASEGSVESASETRSGPQSAST-----AVKERPASSEKVKGGDDHDDTSDSDSDGLTL 161
            ..|.|   .:....|.|....|.|.:.||     |....|.|::.|:|
  Fly   750 VQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRG----------------- 797

Human   162 KELQNRLRRKREQEPTERPLKGIQSRLRKKRREE-----GPAETVGSEA---------------- 205
                  ..|.....|.|.|      ..|.|||.:     |.|.|..|:|
  Fly   798 ------YGRVIYLPPIEAP------TTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQ 850

Human   206 --------SDTVEGVLPSKQEPENDQGVVSQAGKDDRESKLEGKAAQD---IKDEEPGDLGRPKP 259
                    :|:..|..|.:..| .:..:..::....|..||:.....|   .:.:|..|
  Fly   851 PLNTSSLSNDSQPGSGPKRPNP-REPSMARRSTAPRRSKKLDASQNNDPDASESQEDDD------ 908

Human   260 ECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQV 324
                 |||.|:||||||||||||||||.||:||||.|||:::|.|..:|..|.|:.||.|
  Fly   909 -----DPNKLWCICRQPHNNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKC----- 963

Human   325 QDETHSETADQQEAKWRPGDADGTDCTSIGTIEQKSSEDQGI--KGRIEKAANPSGKKKLKIFQP 387
                    ..:||.:.:|...|..........||:.||.:.:  ...|.:.|.||..::
  Fly   964 --------VKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRR------ 1014

Human   388 GPGPVPTQLPVLWQVLEIAVSRSISAFTL----------LHCISCKVIEAPGASKCIGPGCCHV- 441
               .:|..|.|....:.|.:::....|..          |:.|..    .|...|.|....|.|
  Fly  1015 ---TLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRL----GPSPGKRISETLCVVC 1072

Human   442 ---AQPDSVYCSNDCILKHAAATMKFLSSGKEQKPKPKEKMKM--------KPEKPSLPKCGAQA 495
               |...||||..:||.|:|.:.::..::.|...|:......:        |.:|..|.:...:.
  Fly  1073 KRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQ 1137

Human   496 GIKISSVHKRPAPEKKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSP 560
            ...:|.|.:....|:|...|....:.|                    |.|.:.....|.   ||.
  Fly  1138 ADTVSKVERINVFERKSGRVITGHMAP--------------------SAHQFRKWLQEN---PSF 1179

Human   561 SLLYKSTKEDRRSEEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSG 625
            .:|...|.:...:|::..      |.||..:....:||...:.                ||||.|
  Fly  1180 EVLPSGTVQSADAEKRLL------KGAPEAATSTSEPAVLGVA----------------KKPPEG 1222

Human   626 -FKGTIPKRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAP 689
             .|.:.|:...:.|:...|.|:.|     |.|.....|..|                 .:.:|.|
  Fly  1223 PAKLSHPQNTTVQASHQLGISSVR-----PLAKKDKEKTTP-----------------TVQAPTP 1265

Human   690 GRLGAMSAAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTEN------------EVGKIALHI 742
            .|:.|....|      :|..|||||:|.|..|:.::.  ...||            ||.:...::
  Fly  1266 NRIAAGKPEP------VRIGIRRSLREQLLARIKEAQ--AAEENSGQPTTQWPTVLEVDQFVKNV 1322

Human   743 EKEMFNLF-QVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTW 806
            |.||||.| :....:||:||||:|||:||.||:.||.::..:::...:|||:.||:|.|:||:.|
  Fly  1323 ELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKW 1387

Human   807 KERPARSVMESRTK--------LHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPE-KST 862
            :|...|..::...|        ..|...||...:|.|....|   |:..||....|.::.: |.|
  Fly  1388 REEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVD---VTLPEENVSEASSMADTKQT 1449

Human   863 APLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSA 927
            :.:.:..:|.|:.:||:.:|                     ...|:|...|.|..  ..|...|.
  Fly  1450 SLVSEPSTSTLERSTSREKA---------------------GSSKEKRHKSHKHH--HRKRSRSR 1491

Human   928 PDPAPDSADEVMPEAVPEVASEPGLESASHPNVDR------TYFPGPPGDGHPEPSPLEDLSPCP 986
            .:....|.|:.......|...:||.....|.:.::      ...|.|    .|:.....|.||.|
  Fly  1492 SNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREKQSRERDEIVPSP----LPKKRDENDQSPVP 1552

Human   987 ASCGSGVVTTVTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAK 1051
                             .:||...:   .|||.:..|  .::|:.:.|.:         .:.|.|
  Fly  1553 -----------------KKTAEKKT---EASAYNLVD--QILESEKTVEQ---------AANLGK 1586

Human  1052 PSSSPDPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLST--IWKGFINMQSVAKFVTKAYPVSG 1114
            |..||       .|.|.:.:|.....|..:.:.:|..|:|  :|.|.:.|..:|.|....|||.|
  Fly  1587 PKPSP-------KPLPTLPSSLKAPEPMDNYSRYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQG 1644

Human  1115 CFDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSR 1179
            ....|...:|..:.:.|||....||:|:.|||.|.:||:.::...||:..|...:...:.|..||
  Fly  1645 NCHQLGNLMPSQMDVIGRITRVNVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSR 1709

Human  1180 GRFGVVANNNRHVKDLYLIPLSAQDPVPSKL-----LPFEGPGLESPRPNIILGLVICQKIKRPA 1239
            .|.||:..::..::|.|:.||.:.|.:|..|     :||..   |:.|||.:||:::....||||
  Fly  1710 QRLGVLGVDSDQIRDFYIFPLGSGDKLPPALQTAEPVPFYE---EAQRPNTLLGIIVRCLSKRPA 1771

Human  1240 NSGELDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPPPPPLP 1304
            ::                   ||:.|.|                             |.|.|.|.
  Fly  1772 DA-------------------VPSTPSV-----------------------------PTPVPALS 1788

Human  1305 EPPVLKVLSSLK-PAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQTLFGKKKSFDPSA 1368
            .....:..||:. ||..||....:|.:.:|                          |...||..|
  Fly  1789 SKVAKRSRSSISYPAQSSPKRKISTHSTSS--------------------------KDDEFDIDA 1827

Human  1369 --REPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEEDDRPYDPEEEYDPER 1431
              :.|....       :.||...||.|.:                        |.|.:|.|.|..
  Fly  1828 IIKAPIAKL-------QKTAPKVVPQPSV------------------------PNDADEPYSPGG 1861

Human  1432 AFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETILEEAKVTVDDLPNRMCADVRRNSVERP 1496
            :.|            |..|.|           |:                       |.|.:||
  Fly  1862 SDD------------ELVPSA-----------PQ-----------------------RPNDLER- 1879

Human  1497 AEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLE-----EQEEALRQQRAAVGVSMAHFSVSDAL 1556
                             .:.|:||||..|:.::.     |...:.........:|:. .::|..|
  Fly  1880 -----------------QVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAISIP-ANLSKIL 1926

Human  1557 MSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDPRQARRLATETGEGEGEPLSRLSARG 1621
            .|...|::||.:.....|:.:.:...:   |:.:...:.||...|||..:   |.|.||.:....
  Fly  1927 ASIKDKTNLPSSADDGDEEYNPEDDIT---ATSSFASKKPRSKGRLAHLS---EAELLSMVPDNL 1985

Human  1622 AQGALPERDASRGGLVGQAPM-PVPEEKEPASSPWASGEKPPAG 1664
            | |.:|....:|..| .|:|: |.|....|          ||.|
  Fly  1986 A-GVIPRSSRTRHQL-AQSPLTPTPLPPPP----------PPPG 2017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIDO1	XP_011526806.1	TNG2	<160..302	CDD:227367	52/173 (30%)
		PHD_DIDO1_like	266..319	CDD:277109	35/52 (67%)
		TFS2M	708..809	CDD:128786	43/113 (38%)
		SPOC	1093..1199	CDD:285043	34/105 (32%)
pps	NP_001247075.1	TNG2	<827..965	CDD:227367	51/162 (31%)
		PHD_PHF3_like	914..963	CDD:277027	32/48 (67%)
		BRK	1142..1186	CDD:197800	12/66 (18%)
		TFIIS_M	1274..1396	CDD:284835	47/129 (36%)
		SPOC	1623..1729	CDD:285043	34/105 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6514
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007937
OrthoInspector	1	1.000	-	-		otm41808
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11477
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.990