DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DIDO1 and ash1

DIOPT Version :9

Sequence 1:XP_011526806.1 Gene:DIDO1 / 11083 HGNCID:2680 Length:2276 Species:Homo sapiens
Sequence 2:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster


Alignment Length:2111 Identity:373/2111 - (17%)
Similarity:632/2111 - (29%) Gaps:823/2111 - (38%)


- Green bases have known domain annotations that are detailed below.


Human     9 NEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQL---------------G 58
            ||.|...:..|.:             |:..|:.:.|.|.:.....|.:.               |
  Fly     6 NETAAAKVLETQR-------------AQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDG 57

Human    59 LSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASETRS 123
            |.:|.|..:|       ....:|.::..:|..:|.:|:  .:.|                ||.::
  Fly    58 LRMRISAIRP-------TLGVVATKKPPKSRKMSTQDT--ESGC----------------SEAKN 97

Human   124 GPQSASTAVKERP-ASSEKVKGGDDHDD---------TSDSDSDGLTLKELQNRLRRKREQEPTE 178
            ...|....||.:. |||..:...|....         :|||:.| |.||..|.|           
  Fly    98 RAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDD-LPLKVHQQR----------- 150

Human   179 RPLKGIQSRLRKKRREEGPAETVGSEASDT-----VEGVLPSKQEPEND---QGVVSQAGKDDRE 235
            .|...:.:.::..:....|...:|..:||.     |:..:...:....|   :|...:|.||...
  Fly   151 APRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNL 215

Human   236 SKLEGKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGIS 300
            .:.:....||..:         |.:..|...||                                
  Fly   216 PQYQSTLLQDFME---------KTQMLGQTVNA-------------------------------- 239

Human   301 EARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRP-------------GDA--DGTDC 350
                :|.|..          :.:.::||..:||..::.:.||             |.|  :..|.
  Fly   240 ----KLAEEK----------VAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADS 290

Human   351 TSIGTIEQKSSEDQGIKGRIEKAANPSG--------KKKL-------------KIFQPGP----- 389
            ..|.|.....|.....|.:.|.|. |:|        |.|:             ::..|.|     
  Fly   291 GVISTTSTTQSTTPSPKMQNENAV-PTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRR 354

Human   390 -----------GPVPTQLPVLWQVLEIAVSRSISAFTLLHCISCKVIEAPGASKCIGPGCCHVAQ 443
                       .....||..||:  ||.|::...    |..:|.......|||..|   |..|..
  Fly   355 QNNKKTACSSSNKEELQLDPLWR--EIDVNKKFR----LRSMSVGAASGTGASTTI---CSKVLA 410

Human   444 PDSVYCSNDCILKHAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAP 508
            ..|.|.|:...::|..::...                                   :|.:|..|.
  Fly   411 AKSGYVSDYGSVRHQRSSHNH-----------------------------------NSGYKSDAS 440

Human   509 EKKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRS 573
            .|...:.|..:...:|:::.|..:.|:.|..|..      .::.::.|    |:|.||:.:|...
  Fly   441 CKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGL------RMRRKRRA----SMLLKSSADDTVE 495

Human   574 EEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSA 638
            ::....:|        |.::|          :.|..:|...:.|::|..|:              
  Fly   496 DQDILQLA--------GLSLG----------QSSEESNEYISKPSLKSLPT-------------- 528

Human   639 TPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSA------ 697
                               |:||||:       |.:.:.|......     ||.|::||      
  Fly   529 -------------------TSASKKY-------GEINRYVTTGQYF-----GRGGSLSATNPDNF 562

Human   698 ------------APSQPNSQIRQNIRRSLKEILWKRVNDSDDL-------IMTENEVGKIALHIE 743
                        |||:.:.:|:.. |.|...:....|:....:       ..:.|:    :|:|:
  Fly   563 ISKMMNQRKETPAPSKSSCKIKSR-RSSAASMCSSYVSGVSRMRRRHRRKSFSHNK----SLNID 622

Human   744 KEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLF--HRVLREEISL-AKLVRLKPEELVSKELST 805
            .::....::..:.:.|:.|     ::|.:..|..  .::|.:...| |.|....|    :::|:.
  Fly   623 SKLLTEIEIITSTFNSRCR-----IQDDRLTGSSGKEKLLADANKLQATLAAPSP----AQQLTL 678

Human   806 WKERPARSVMESRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFS 870
            ....||             |..:.|.:..:...:.|.|:.|......||...|..|        .
  Fly   679 NGGGPA-------------STLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGS--------G 722

Human   871 SMLKDTTSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPDSA 935
            |...:|..:|:.              ..:.|..:|...||       .||.:|....|...|.: 
  Fly   723 SSNGNTKRRHKK--------------SQSNDSSSPDDHKL-------PLKKRHYLLTPGERPPA- 765

Human   936 DEVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTTVTVS 1000
                     |||...|..:|.                            ..|:..:...:|.:..
  Fly   766 ---------EVAFANGKLNAE----------------------------AWAAAAAAAKSTASTK 793

Human  1001 GRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSPDPRYLSVPP 1065
            .:....|.|      ..:|..|...|::|....|.....::...|..|:...:|....:.|.:.|
  Fly   794 SQAQFNARS------VKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISP 852

Human  1066 SPNISTSESRS------------------------PPEG--------DTTLFLSRLSTIWKGFIN 1098
            |...|..:.|.                        ||.|        :..:.||:|:        
  Fly   853 SSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLN-------- 909

Human  1099 MQSVAKFVTKA---YPVSGCFDYLSED---------LPDTIH-IGGRIAPK--------TVWDYV 1142
             :||   :|||   .|:....| :.||         :...:| .||.:..|        |.:..|
  Fly   910 -ESV---ITKAEVESPLLSALD-IKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTV 969

Human  1143 GKLKSSVSKE---LCLIRFH-PATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQ 1203
            .:.|..||.|   ..:|..| |..:.::....||....||         ||.:|:      .:..
  Fly   970 RRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSS---------NNVNVQ------AAPN 1019

Human  1204 DPVPSKLLPFEGPGLE---------SPRPNIILGLVICQKIKRPANSGELDKMDEK-RTRLQPEE 1258
            .|:..:.:|..|...|         :||    |.:|..::::||...........| :.|.|.|.
  Fly  1020 PPLDCERVPQAGEARETFVARTNQKAPR----LSVVALERLQRPQTPARGRPRGRKPKNREQAEA 1080

Human  1259 ADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPP------------------------ 1299
            |..|. ||.....:..||..:.|    ...|...||.:|||                        
  Fly  1081 APQPP-PKSEPEIRPAKKRGRQP----KQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFS 1140

Human  1300 -------------------------------PPPLP-------EPPVLKVLSSLK------PAA- 1319
                                           ||.:|       .....|.|.|:.      ||: 
  Fly  1141 CKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASE 1205

Human  1320 ---PSPATAATTAAAASTAASSTA----SSASKTASPLEHILQTLFGK--KKSFDPSAREPPGST 1375
               |.|...|:.:.::...||:|:    |...||     :::..||..  |:|..|    ||   
  Fly  1206 SHNPGPQDYASCSESSEDKASTTSLRKLSKVKKT-----YLVAGLFSNHYKQSLMP----PP--- 1258

Human  1376 AGLPQEPKTTAEDG----VPAPPLLDPIVQQFGQFSKDKALEEEEDDRPYD-------------- 1422
            |.:.::|....:.|    :|.||..:..:::          .|.:.:.|||              
  Fly  1259 AKVNKKPGLEEQVGPASLLPPPPYCEKYLRR----------TEMDFELPYDIWWAYTNSKLPTRN 1313

Human  1423 --PEEEYDPER-------------AFD-------------------TQLV------------ERG 1441
              |...|...|             .||                   .::|            |:.
  Fly  1314 VVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKC 1378

Human  1442 RRHEVERAPEAAAAEREEVA----------------YDPE--DETILEE------AKVTVDDLPN 1482
            |..:::|...|...||...|                |..|  .|.:.|:      |.:.::|..:
  Fly  1379 RNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHH 1443

Human  1483 --------------RMCADVRRNSVERPAEPVAGAATPSLVEQQK-MLEELNKQIEEQKRQLEEQ 1532
                          ||.:|.|  .|....||..        |.|| .:..|::.:...||.:||.
  Fly  1444 YCLHLDGGLVIDGQRMGSDCR--FVNHSCEPNC--------EMQKWSVNGLSRMVLFAKRAIEEG 1498

Human  1533 EEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLPKAE--LFQQEQQSADKPA-SLPPASQASNHR 1594
            ||.....         :||:.:.....|.:.:.|:..  :..:.|:....|| ...|:.:..:.|
  Fly  1499 EELTYDY---------NFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGR 1554

Human  1595 DPRQARRLATETGEGE-GEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEP-------- 1650
            :.||.::.|.:..:.: |:.:|...|......|.|::..   ||.|....:....|.        
  Fly  1555 NGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKK---LVRQFNTFLVRNFEKIRRCKAKR 1616

Human  1651 ASSPWASGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGE 1715
            ||...|:...|..|:                |.||.   |.||   |:.|               
  Fly  1617 ASDAAATASSPALGT----------------TNGDI---PGRR---PSTP--------------- 1644

Human  1716 RDPFTCPGFASQDKALGSAQYEDPRNLHSAG 1746
                :.|..|:|..||.|     |||:.:.|
  Fly  1645 ----SSPSLAAQISALCS-----PRNIKTRG 1666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIDO1XP_011526806.1 TNG2 <160..302 CDD:227367 21/149 (14%)
PHD_DIDO1_like 266..319 CDD:277109 4/52 (8%)
TFS2M 708..809 CDD:128786 16/110 (15%)
SPOC 1093..1199 CDD:285043 29/130 (22%)
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 5/47 (11%)
SET 1392..1512 CDD:214614 28/138 (20%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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