DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DIDO1 and upSET

DIOPT Version :9

Sequence 1:XP_011526806.1 Gene:DIDO1 / 11083 HGNCID:2680 Length:2276 Species:Homo sapiens
Sequence 2:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster


Alignment Length:2605 Identity:476/2605 - (18%)
Similarity:790/2605 - (30%) Gaps:881/2605 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    33 TIAKRE--GAGDAEADPLEPPPPQQQLGLSLRRSGRQPKRTERVEQFLTIARRRGRRSM------ 89
            |.|:|:  .|..:.|..||.....|||...:...||  |....:|.:    .:.|..|:      
  Fly   575 TAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGR--KAPTVIEYY----NKHGVNSIVGSSNN 633

Human    90 ------------PVSLEDSGEPTSCPATDAETASEGSVESASETRSGPQSASTAVK---ERPASS 139
                        |.|...||..|:.| |.|.......|.......:.|.|:...||   :.||..
  Fly   634 LAQSNSMSNLAGPRSNSGSGFATTTP-TPATPLHLTPVNVPVHVEAAPPSSPALVKGSSQPPAQP 697

Human   140 EKVKG-----GDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERPLKGIQSRLR---------- 189
            ::.:.     |.:..:.:|.:   |.::|:              ||:..:...||          
  Fly   698 QQQQQQAHPLGPNQLNANDEE---LYIEEV--------------RPVPVLTQDLRLQQLHAIMQD 745

Human   190 ----KKRREEGPAETVGSEASDTVE-GVLPSKQEPE------------NDQGVVSQAG------- 230
                .:::::.|.:..|    ||.. |.....|:|:            ..||..:..|       
  Fly   746 HTYASQQQQQQPQQAAG----DTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFG 806

Human   231 --------KDDRESKLE-----GKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFM 282
                    .||..|.:.     |.|:.||   :||:.....||.|..|.:...|||...|::.:|
  Fly   807 QQIARSQADDDAHSAISSSSRMGLASTDI---DPGEETETAPEAEAEDDSVTRCICELTHDDGYM 868

Human   283 ICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWR-----P 342
            ||||:|..|.|.||:||..      :...|:|:|..|....| |:..:....:|:.|..     .
  Fly   869 ICCDKCSAWQHVDCMGIDR------QNIPEEYMCELCQPRAV-DKARARALQRQKRKEHMLLVAT 926

Human   343 GDADGTDCTSIGTI-------------EQKSSEDQGIKGRIEKAANPSGKKKLKIFQPGPGPVPT 394
            ..|:|....:.||.             |.:.....|:.|..  |......||.|..:...|...|
  Fly   927 QAANGAAAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGF--ATGTGMSKKSKKTKENSGSTST 989

Human   395 QLPVLWQVLEIAVSRSISAFTLLHCISCKVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILKHAA 459
                |.:..:.||...                  |.....|.|     .|..             
  Fly   990 ----LKKTKKSAVGMG------------------GEKNASGSG-----TPTG------------- 1014

Human   460 ATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVKKAVVVPAR 524
                  ||||..|...|.|.|...:       |:..|   .|.....|.||....:::       
  Fly  1015 ------SSGKTSKKSSKRKSKSGGD-------GSSGG---GSSPALTAAEKHAANLRQ------- 1056

Human   525 SEALGKEAACESSTPSWASDHNY---NAVKPEKTA-----APSPSLLYKSTKEDRRSEEKAAAMA 581
                            |..::.|   |...||..|     ...||||     :..::.|..|...
  Fly  1057 ----------------WIENYEYAVTNHYSPELRARLHAIQKQPSLL-----QSIQNTENKALRQ 1100

Human   582 ASKKTAPPGSAVGKQPAPR-NLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSATPSSGAS 645
            ..::.:..|||  :|...| .|:|...:...:::...:...|....:|    :..|:....:...
  Fly  1101 IQQQLSTAGSA--EQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRG----KYMLTTQFRTQNP 1159

Human   646 AARQAGPAPAAATAASK--KFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSAAPSQPNSQIR- 707
            ......|.|:....:.|  |.||.  .|...:.|.| ..||.:..|.  |::.....||.|.:: 
  Fly  1160 TVNMNTPPPSNYLNSFKAHKTPGQ--FVFFYQLPGV-EAPMQTLRPD--GSVPQVAQQPPSYLKG 1219

Human   708 --------------QNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYK 758
                          :.:|||.      |.|            .::..:.||...:|:.|      
  Fly  1220 PEVCVDTRTYGNDARFVRRSC------RPN------------AELQHYFEKGTLHLYIV------ 1260

Human   759 SKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVMESRTK--- 820
                            .|.|...:.||:    :|.:|.:|.:.|   .|:..|..:..:.|:   
  Fly  1261 ----------------ALTHIRAQTEIT----IRHEPHDLTAVE---QKKSHAAVIQPTSTRCAC 1302

Human   821 -LHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHL 884
             :.::.....|.  |:.....:||.......:..|.|....:.|               .:.|..
  Fly  1303 DMGSDCLFALPL--AVQQQLQAPPTQPRSSHRNKAAAAAAAAAA---------------ANSAAA 1350

Human   885 FDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDS-------------------SAPDP 930
            ..|...:..|...:|.....|..:..|.|...|..:...:|                   :||.|
  Fly  1351 IQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGLNSPQLGQLNLGFKTSVTATSLTAPVP 1415

Human   931 ---------APDSADEVMPEAVPEVASEPGL-ESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPC 985
                     :..|::.....::..|..:.|: .|:|.|:|           ..|.|:|.:..|| 
  Fly  1416 GVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSV-----------SIPSPTPTQMQSP- 1468

Human   986 PASCGSGVVTTVTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILA 1050
                        |:. :.|:..|....:.:..:   |...|..:....:|.|:||.::.|:  |.
  Fly  1469 ------------TLQ-QHPQQIPQQQLSLLQRS---PTQQHQQQILAALPTPMLTPMLSPQ--LP 1515

Human  1051 KPSSSPDPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGC 1115
            ||:.  ...::.:|.|...|..:.:...:....|.:               :|.......|::..
  Fly  1516 KPAQ--QQAHVVLPQSQQTSLLQQQQSQQSQEPLAV---------------IAAAAAAQQPMATY 1563

Human  1116 F-------DYLSEDLPDTI-----HIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVA 1168
            |       .......|..:     |:.|                 ..::...::.....:::::|
  Fly  1564 FVRQPQQQQQQQSPKPQALVAQQQHVVG-----------------AQQQQHFLQQQQKQQQQQMA 1611

Human  1169 YISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGLESPRPNII--LGLVI 1231
                     ...|..|.|....|.                           :|..:|:  :.:..
  Fly  1612 ---------DEARMAVSALQTLHA---------------------------APTSHIVSPIKVAA 1640

Human  1232 CQKIKRPANSGE--------LDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAA 1288
            .|:..:|....:        ...:.::..:||.:::..|.||:   .||.::||.  |:......
  Fly  1641 VQQQSQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQ---SPQRQQKPQ--PVQHQPQI 1700

Human  1289 VSTTPPGSPPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHI 1353
            |.:|  |:...|..:|    .|:.|..|.|||..:....|.:|.|:..     ...||  |.:|.
  Fly  1701 VIST--GAQAIPATMP----TKLSSPTKSAAPVISNNNITVSAQSSVV-----GGKKT--PAKHP 1752

Human  1354 LQTLFGKKKSFDP-SAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEED 1417
            .|....:::...| ||...|.:|....:    :.||.|.|.....|..:   ..:|||..:..||
  Fly  1753 QQQQQQQQQPVTPVSAATAPAATPSSSE----SKEDDVSASSTTTPTTR---TPAKDKPKQSRED 1810

Human  1418 D------RPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAER---EEVAYDPEDETILEEA 1473
            .      |..:..|:.:.....||:....|:| :...:| |:..:|   ..::.|.|..|....|
  Fly  1811 RKLEAILRAIEKMEKQEARGKKDTRQSSGGKR-QASNSP-ASPNKRNSSNSISEDVETPTSTNSA 1873

Human  1474 KVTVDDLPNRMCADVRRNSVERPAEPVAGAATPSL---------------VEQQKMLEEL-NKQI 1522
                      ..|..|||..:|.........|..|               ||.......| |.:.
  Fly  1874 ----------AAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGESHALTNSES 1928

Human  1523 EEQKRQLEEQEEALRQQRAAVGVSMAH-----------------------FSVSDALM------- 1557
            |:|.:..:........|.|.:.:::||                       .|||.|.:       
  Fly  1929 EDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMG 1993

Human  1558 ----SPPPKSSLPK-AEL-----------------FQQ-EQQSADKPASLPPASQASNHRDPRQA 1599
                .|.|.|:.|. ||.                 ||| |||.|....||..|:.:..:.:..|.
  Fly  1994 PLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQL 2058

Human  1600 RR------------LATETGEGEGEPLSRLSARGAQGALP------------------------E 1628
            :|            |..|....:.|..:.:.|| .|..||                        |
  Fly  2059 QRQPQGESLPAPALLKVEQFIHQAESTTAVPAR-EQLHLPLQNNSSVKKRWLRQAISEETTPVDE 2122

Human  1629 RDASRGGLVGQAPMPVPEEKEPASSPWASGEKPPAGSEQ-----DGWKAEPGEGTRPATVGDSSA 1688
            ...|:...|...|.|.|   .|..||.|:|...|....:     :|...|..| |....:|:...
  Fly  2123 LQQSQNQSVTATPSPQP---VPTVSPLANGFSTPLKKRRLVVVSNGTNVESDE-THIDVIGEPKD 2183

Human  1689 RPARRV---------------------LLPTPPCGA-----------LQP------GFPLQHDGE 1715
            .....|                     :|.:|..|.           ::|      ...::.|.|
  Fly  2184 EAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVE 2248

Human  1716 RDPF-TCPGF-----------ASQDKALGSAQ----YEDPR------------NLHSAGRSSSPA 1752
            |:.. .|..|           ..::|.:...|    :|.|:            .:..|.....|:
  Fly  2249 REESQACDKFEEMVKVKREEEEQREKEIKQLQERQEHEQPKVEPAPVEPKLENTVAKAEPKVEPS 2313

Human  1753 GETEGDREP---QARPGE------GTAPLPPPGQKVGG------------SQPPFQGQREPGPHA 1796
            .|....:||   :.:|||      .|....|....:..            ::||.:.:.||....
  Fly  2314 QEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKK 2378

Human  1797 LGM-SGLHGPNFPGPRGPAPPFPEENIASNDGPRGPPPARFGAQKGPIPS-----------LFSG 1849
            ..: |.|..|....|....||.|..:.|:.........|.......|..:           |.|.
  Fly  2379 PKLESILPAPVATVPPVSVPPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSF 2443

Human  1850 QHGPPPYGDSR---------GPSPSY----LGGPRGVAPSQFEERKDPHGEK------------- 1888
            ......|..||         ..|||.    ..|..|....:..:.||...:|             
  Fly  2444 HAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKK 2508

Human  1889 ---REFQDAPYNEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQRRPLLSQLKGPRGGPPPSQFGG 1950
               :|.|.|..|  ..:.:|...|::.....|:..:.....    |:|         .|||    
  Fly  2509 SKDKEKQKAAVN--VNSTSQIVDTKKKTTQPSKPDSKSSIA----PVL---------VPPS---- 2554

Human  1951 QRGPPPGHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQPQQFEDQRVH------ 2009
                             ....||.|.       .:..|.|      .:..||.:..|..      
  Fly  2555 -----------------LPVATANGK-------TKHTAYN------NVDQQQQQQMRRRTMSMCI 2589

Human  2010 SPPRFTNQRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPRPL-----------L 2063
            :|...|....|:|     |.|:.| |.|..||    :|:   .::.||..:.|           |
  Fly  2590 TPVTPTPVVTPSP-----LHGTPP-STKKRQT----NFE---QELTKPNSQILSSSILLNSSKGL 2641

Human  2064 ELPSHPP------------QHRKD-RWEEAGPPSALSSSAPGQGPEADGQWASADFREGK--GHE 2113
            .||...|            ||||: ..:||.|.|.        ||.:    .:|....||  ...
  Fly  2642 GLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASG--------GPMS----LAAAIASGKLNAIS 2694

Human  2114 YRNQTFEGRQRERFDVGP--KEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRD 2176
            .|.::..|.::::..:..  |::..|:..::.:..|.::.::::|:...||:|          ::
  Fly  2695 RRRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKD----------KE 2749

Human  2177 KDSSR 2181
            ||:.:
  Fly  2750 KDNKQ 2754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIDO1XP_011526806.1 TNG2 <160..302 CDD:227367 44/188 (23%)
PHD_DIDO1_like 266..319 CDD:277109 19/52 (37%)
TFS2M 708..809 CDD:128786 18/100 (18%)
SPOC 1093..1199 CDD:285043 11/117 (9%)
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 19/48 (40%)
SET <1221..1273 CDD:214614 13/95 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

Return to query results.
Submit another query.