DRSC/TRiP Functional Genomics Resources

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Protein Alignment KERA and CG18095

DIOPT Version :9

Sequence 1:NP_008966.1 Gene:KERA / 11081 HGNCID:6309 Length:352 Species:Homo sapiens
Sequence 2:NP_001188805.1 Gene:CG18095 / 34823 FlyBaseID:FBgn0028872 Length:564 Species:Drosophila melanogaster


Alignment Length:270 Identity:73/270 - (27%)
Similarity:130/270 - (48%) Gaps:35/270 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    76 LYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPL 140
            |.|.:|::..:..|.||...||:.::|..|:|:.  ||..:...|..|..|:|..|:|..:....
  Fly   116 LDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQ--IENDSFDGLSHLKHLYLNGNQLAHIDGSF 178

Human   141 PRSLEQ---LQLARNKVSRIPQGTFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKN 202
            .|.|.:   |.|..|::..|...:|.:..:|..|.|..|.|  ::.|..:.:||..|:.||::.|
  Fly   179 FRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLL--SSLQFLSQRGLARLVHLNLSSN 241

Human   203 ALRNMPPRLPANTMQ---LFLDNNSIEGIPENYFNVIPKVAFLRLNHN---KLSDEGLPSRGFDV 261
            .|:.:.|.:.:...:   |.|..|:|..:.:...:.:..:..|.::||   |:.||.|.|    :
  Fly   242 LLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDS----L 302

Human   262 SSILDLQLSHNQLTKVP----RISAHLQHLHLDHNKIKSVNVSVICPSPSMLPAERDSFSYGPHL 322
            .::|.|.:|.|.||.:|    ..:..|:.:.|.:|||:.::..::             |:.. ||
  Fly   303 IALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMM-------------FNQN-HL 353

Human   323 RYLRLDGNEI 332
            ||::|.||.|
  Fly   354 RYIKLSGNAI 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KERANP_008966.1 NEL <48..>311 CDD:330839 64/247 (26%)
LRR 1 72..93 5/16 (31%)
leucine-rich repeat 73..96 CDD:275380 6/19 (32%)
LRR 2 96..117 7/20 (35%)
leucine-rich repeat 97..122 CDD:275380 7/24 (29%)
LRR 3 122..142 5/19 (26%)
leucine-rich repeat 123..143 CDD:275380 5/19 (26%)
LRR 4 143..164 6/23 (26%)
leucine-rich repeat 144..167 CDD:275380 6/25 (24%)
LRR 5 167..180 5/12 (42%)
leucine-rich repeat 168..193 CDD:275380 8/24 (33%)
LRR 6 193..213 6/19 (32%)
leucine-rich repeat 194..217 CDD:275380 6/22 (27%)
LRR 7 214..235 4/23 (17%)
leucine-rich repeat 218..238 CDD:275380 4/19 (21%)
LRR 8 238..258 8/22 (36%)
leucine-rich repeat 239..264 CDD:275380 8/27 (30%)
LRR 9 263..282 7/22 (32%)
LRR 10 283..304 5/20 (25%)
leucine-rich repeat 284..321 CDD:275380 6/36 (17%)
leucine-rich repeat 322..343 CDD:275380 7/11 (64%)
CG18095NP_001188805.1 leucine-rich repeat 41..64 CDD:275380
LRR_8 64..123 CDD:290566 3/6 (50%)
leucine-rich repeat 65..88 CDD:275380
leucine-rich repeat 89..112 CDD:275380
leucine-rich repeat 113..136 CDD:275380 6/19 (32%)
LRR_RI 115..384 CDD:238064 73/270 (27%)
LRR_8 135..195 CDD:290566 18/61 (30%)
leucine-rich repeat 137..160 CDD:275380 7/24 (29%)
leucine-rich repeat 161..184 CDD:275380 7/22 (32%)
LRR_8 184..243 CDD:290566 17/60 (28%)
leucine-rich repeat 185..208 CDD:275380 5/22 (23%)
leucine-rich repeat 209..232 CDD:275380 8/24 (33%)
LRR_8 232..289 CDD:290566 11/56 (20%)
leucine-rich repeat 233..256 CDD:275380 6/22 (27%)
leucine-rich repeat 257..280 CDD:275380 4/22 (18%)
LRR_8 280..339 CDD:290566 18/62 (29%)
leucine-rich repeat 281..304 CDD:275380 8/26 (31%)
leucine-rich repeat 305..328 CDD:275380 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45712
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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