DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHD4 and mit1

DIOPT Version :9

Sequence 1:	NP_001264.2	Gene:	CHD4 / 1108	HGNCID:	1919	Length:	1912	Species:	Homo sapiens
Sequence 2:	NP_595385.1	Gene:	mit1 / 2541336	PomBaseID:	SPBP35G2.10	Length:	1418	Species:	Schizosaccharomyces pombe

Alignment Length:	1355	Identity:	375/1355 - (27%)
Similarity:	592/1355 - (43%)	Gaps:	334/1355 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   253 VEVPIRK---AKTKEGKG-------PNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKR 307
            ||..|:|   .|.|.||.       ..:|::..|.....| |..:.|....||..    |||..|
pombe    51 VEALIKKDELDKYKNGKACLRVWLKHKSRKRYHGYMTSTD-KDEEEKNDYLLKSN----GSKVLR 110

Human   308 SSSEDDDLDVESDF----DDASINSYSVSDGSTSRSSRSRKKLRTTKKKKK-------------G 355
            .|:.........:|    :.:.::..:.||.:||.||.:.||:...:..:.             |
pombe   111 DSTRTKKFKFGKEFHCALNPSFVSDETASDSATSSSSDTNKKVNRKEHNELSLSHLSFNDTSDFG 175

Human   356 EEEVTA--VDGYETD--------------------HQDYCEVC------QQGGEIILCDTCPRAY 392
            ..::::  ::..|.|                    |...|..|      ..|...:.||.|...|
pombe   176 SSDLSSSEIESTENDNKAPYFSLLYSDGFDFIKFLHVCVCVKCHGREHRSSGKNFVYCDHCSNVY 240

Human   393 HMVCLD-PDMEK-----APEGKWSCPHCEK------------EGIQWEAKEDNSEGEEILEEVGG 439
            |..|.. |.:.|     :.:..:.||.|.|            .|:        |.|::::  :..
pombe   241 HYDCSPLPSLNKETRNYSQQNGFICPLCSKNSKDVLCNTGFVSGV--------SSGQDLV--IPP 295

Human   440 DLEEEDDHH--MEFCRV-------CKDGGELLCCDTCPSSYH---IHCLNPPLPEIPNGEWLCPR 492
            .|.:.:...  :.:|:.       |:........|:.|.|..   .|.:.         :.:|..
pombe   296 SLADRESLSILVNYCKSIRFRCFRCRRVEYFFYLDSNPLSIQRTITHFIK---------KLVCNE 351

Human   493 CT---CPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWH 554
            |:   |     .:::|:.|:    ...:..|.......|..|...|... .|::||:.:|.||.|
pombe   352 CSMHPC-----DIEEIIAWR----TLNSLYPSKATLSNNFVSTSDLSFW-SREYFVRSKGKSYLH 406

Human   555 C-----SWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKS------------------- 595
            |     ||::.:.|.          ::||         |.|.|..|
pombe   407 CFWCSASWLAGISLA----------KKKN---------FDGLENASYDATKPIIPVSYTIIDKVW 452

Human   596 --RKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHY-LIKWRDLPYDQASWESE 657
              :.|..|:.:.|:                 ::...|.:.....|.: .:.||.|.|..::||..
pombe   453 DVQYRSGKNARTAK-----------------YKTKKHQLKAISEVTFAFVSWRGLTYYMSNWEPP 500

Human   658 DVE---------IQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVD-----P 708
            ..|         ::.|....:..|                        :|:.| |.:::     .
pombe   501 PKETDRNRWKAWLKGYSDLLECLW------------------------IEKAP-TASINIDLPFT 540

Human   709 TVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGH 773
            .:::..||.::  .||||.|||::|||||...|......|||||||||||||...|:..|:.. |
pombe   541 NLEWHSQPSFI--KGGTLMPYQLKGLNWLYLRWYTHHPCILADEMGLGKTVQVISFISVLFYR-H 602

Human   774 SKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMK 838
            ...|.||..|.:|:.|||||.:.|||.:.:...||.:.:|:::|:             .:....|
pombe   603 KCFPVLVIVPHATVANWERELKKWAPFLQINVLVGSEKNRSLVRD-------------YRLINQK 654

Human   839 KEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGT 903
            ....|..|||:.|...:..::::|....|..|||||..||||:||..|..|:......|||||||
pombe   655 DPKHVSTHVLVISASNVEREISLLRKFQWKVLIVDEGQRLKNDQSSLFYYLSSVKSDFKLLLTGT 719

Human   904 PLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPS 968
            |||||:.|||:||.||.|.:.:..|  ||:...|...:::.:||.:|.|..|||:|::|..|.|:
pombe   720 PLQNNVRELFNLLQFLNPMKINAAE--LEKRYSIIDTEKVTELHQILKPFFLRRVKSEVLDNFPT 782

Human   969 KTELIVRVELSPMQKKYYKYILTRNFEAL---------NARGGGNQVSLLNVVMDLKKCCNHPYL 1024
            |.|:|:.:.::|:||..||.||::|...|         ::.||....||.|::|.|:|...|||:
pombe   783 KVEVIIPLSMTPVQKGLYKSILSKNLSLLRNITGYANTSSSGGQRTTSLNNILMQLRKTLAHPYI 847

Human  1025 FPVAAMEAPKMPNGMYDGS--ALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLE 1087
            :. ..:|...:|   |:.:  :|..||.|.|:|:.::..|...|||:|:|||..:.||:|||:.|
pombe   848 YS-PDIEDRNLP---YELAMRSLEEASCKFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFE 908

Human  1088 HEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHN 1152
            ::...|.|.||..:...||.|||.||||.::..||||||||||:|||||:||||||.|.|:|||.
pombe   909 YKNIAYARFDGASSEMERQSAIDSFNAPNSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQ 973

Human  1153 DIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDD 1217
            |:||.:||||.||.|||:::...||.||||:|.|.|:||::|.||:|.   .......|:::|:.
pombe   974 DMQAIARAHRYGQKKKVLVFVLTTRDSVEEKIIQNAQKKLVLDHLIVE---SLDQNHNSEKDLES 1035

Human  1218 ILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLL---DRNQD-ETEDTELQGM----- 1273
            ||:.|...||           :|..|...|.|::.::|.|:   ::.:| .|::::::..
pombe  1036 ILRHGARALF-----------EEAGDEPSIKYNEYSVELLISEAEKQEDTSTDESDIKSNKFGFF 1089

Human  1274 ----NEYLSSFKVAQYVVREEEMGEEEEVEREIIKQE------ESVDPDYWEKLLR-HHYEQQQE 1327
                |:::||   ..|.|:|..:.:||:|...|:||.      |..|.....:.|| ||.....|
pombe  1090 RVWDNKHISS---NHYEVKENVLVDEEDVWSVILKQREKDAMLEKTDETTSNRRLRAHHKIHYGE 1151

Human  1328 DLARNLGKGKRIRKQVNYNDGSQEDRDWQ-DDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKG 1391
            ||              |..|.| :|.|:. :|:|...|.:.:.:|......|..|:      ::.
pombe  1152 DL--------------NIYDNS-DDTDYTVNDRSSPGSPFPIETETISSITDTLSD------KQK 1195

Human  1392 LRNDKDKPLPPLLARVGGNIEVLGFNARQRKA---FLNAIMRYGM----PPQDAF 1439
            |:.|...           |||.|...:..:|:   ..::|:...:    |.:|.|
pombe  1196 LKYDSSV-----------NIENLNDESDSQKSADVHFDSILAKSLLATTPKEDEF 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHD4	NP_001264.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157
		CHDNT	164..216	CDD:285335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..360		30/133 (23%)
		PHD1_CHD_II	372..414	CDD:277006	13/53 (25%)
		PHD2_CHD_II	451..493	CDD:277007	7/51 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..538		4/27 (15%)
		CHROMO	<540..577	CDD:237991	11/41 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..603		7/45 (16%)
		CHROMO	622..676	CDD:214605	11/63 (17%)
		SNF2_N	729..1025	CDD:278600	120/304 (39%)
		DEXDc	746..904	CDD:238005	60/157 (38%)
		DEAH box	873..876		2/2 (100%)
		Helicase_C	1068..1164	CDD:278689	57/95 (60%)
		DUF1087	1302..1352	CDD:283996	15/56 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1344..1401		13/57 (23%)
		DUF1086	1385..1521	CDD:283992	11/62 (18%)
		Neuromodulin	<1517..1649	CDD:284117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1525..1562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1570..1589
		Required for interaction with PCNT. /evidence=ECO:0000269\|PubMed:17626165	1577..1912
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1594..1644
		CHDCT2	1726..1896	CDD:285336
mit1	NP_595385.1	PHD	214..268	CDD:214584	13/53 (25%)
		SNF2_N	559..847	CDD:278600	119/303 (39%)
		DEXDc	577..720	CDD:238005	60/156 (38%)
		Helicase_C	870..985	CDD:278689	64/114 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910