Protein Alignment TPPP and Tppp

DIOPT Version :10

• Sequence 1: XP_016864482.1
• Gene: TPPP / 11076
• HGNCID: 24164
• Length: 286
• Species: Homo sapiens
• Sequence 2: NP_878259.1
• Gene: Tppp / 72948
• MGIID: 1920198
• Length: 218
• Species: Mus musculus
• Alignment Length: 220
• Identity: 202/220 - (91%)
• Similarity: 211/220 - (95%)
• Gaps: 3/220 - (1%)

Human    68 MAD-KAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAASPELSALEEAFRRFAVHGDA 131
            ||| |||||||||:|||||||||:  |||||||||||||.|||.|:||||||||||||||||||.
Mouse     1 MADSKAKPAKAANKTPPKSPGDPA--RAAKRLSLESEGANEGATAAPELSALEEAFRRFAVHGDT 63

Human   132 RATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFK 196
            ||||:||||||||||||||.||||:||||||||||||||||||||||||||||||||||||||||
Mouse    64 RATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFK 128

Human   197 DKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVD 261
            |||||||||||||||||:||:|||||||:|||||||||||:|||||||||||.||||||||||||
Mouse   129 DKSSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVD 193

Human   262 LVDESGYVSGYKHAGTYDQKVQGGK 286
            ||||||||.||||||||||||||||
Mouse   194 LVDESGYVPGYKHAGTYDQKVQGGK 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPPP	XP_016864482.1	p25-alpha	119..274	CDD:461670	144/154 (94%)
Tppp	NP_878259.1	Mediates interaction with LIMK1. /evidence=ECO:0000250|UniProtKB:O94811	1..115		103/115 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		38/46 (83%)
		p25-alpha	51..206	CDD:461670	144/154 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..192		23/25 (92%)