DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUS4L and CG10495

DIOPT Version :9

Sequence 1:	NP_001257348.1	Gene:	DUS4L / 11062	HGNCID:	21517	Length:	317	Species:	Homo sapiens
Sequence 2:	NP_609939.1	Gene:	CG10495 / 35179	FlyBaseID:	FBgn0032750	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	138/323 - (42%)
Similarity:	202/323 - (62%)	Gaps:	22/323 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    12 QERKKDPIEMFHSGQ--LVKVCAPMVRYSKLAFRTLVRKYSCDLCYTPMIVAADFVKSIKARDSE 74
            |....|...||...|  .|:|.|||||||||.||.|||.....|.:|||:::.....|.|||.:|
  Fly     6 QRPHHDIAAMFAEAQSDFVRVSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNE 70

Human    75 FTTNQGDCPLIVQFAANDARLLSDAARIVCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQD 139
            |:|...|.|||.||||.|......:|:::.||.:|||:||||||.||||:|||..::.:||||..
  Fly    71 FSTGADDQPLIAQFAAKDPTEFVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVHQ 135

Human   140 MVKQVRNQVETPG-FSVSIKIRI---HDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQPVHYD 200
            :|::||..:  || ||||:|:|:   .:.|:||:||.::.|:.||:::|:||||..::|..   |
  Fly   136 VVQEVRRTL--PGDFSVSVKMRLLGGEESLQRTIDLARQLESAGVTFLTLHGRTPAQKHSK---D 195

Human   201 SIKI-----IKENMSIPVIANGDIRSLKEAENVWRITGTDGVMVARGLLANPAMF-AGYEE---T 256
            ::.|     :::::.||:|.||::.|.::|.::...||..|||.|||||||||:| :.|.:   |
  Fly   196 TLDIPAMSQVRQSLQIPLIVNGNVESYRDACDMHEQTGAAGVMAARGLLANPALFNSNYPDGKTT 260

Human   257 PLKCIWDWVDIALELGTP--YMCFHQHLMYMMEKITSRQEKRVFNALSSTSAIIDYLTDHYGI 317
            ||.|:..|:|||...|..  :.|||.||.:|......|..:..||:|.|...::|:|.:||.:
  Fly   261 PLSCVQQWLDIASAAGDNLLFQCFHHHLTFMYSAQMKRDLRVQFNSLGSKEQVVDFLKEHYNL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUS4L	NP_001257348.1	DUS_like_FMN	28..257	CDD:239200	109/241 (45%)
CG10495	NP_609939.1	DUS_like_FMN	26..251	CDD:239200	106/229 (46%)
CG10495	NP_609939.1	Dus	28..321	CDD:279540	129/297 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145115
Domainoid	1	1.000	232	1.000	Domainoid score	I2434
eggNOG	1	0.900	-	-		E1_COG0042
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6535
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54379
OrthoDB	1	1.010	-	-		D1345916at2759
OrthoFinder	1	1.000	-	-		FOG0004835
OrthoInspector	1	1.000	-	-		oto89546
orthoMCL	1	0.900	-	-		OOG6_104072
Panther	1	1.100	-	-	LDO	PTHR11082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R357
SonicParanoid	1	1.000	-	-		X4511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800