DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWP2 and RSP5

DIOPT Version :9

Sequence 1:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens
Sequence 2:	NP_011051.3	Gene:	RSP5 / 856862	SGDID:	S000000927	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	917	Identity:	351/917 - (38%)
Similarity:	481/917 - (52%)	Gaps:	174/917 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    18 SQLTLKVVSAKPKVHN---RQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIIL-NVTAQ 78
            |.:::|:|:|:.....   |.|  :.:..:.:||.  :||.|.....:....|||.... ::...
Yeast     3 SSISVKLVAAESLYKRDVFRSP--DPFAVLTIDGY--QTKSTSAAKKTLNPYWNETFKFDDINEN 63

Human    79 SHLDLKVWSCHTLRNE---LLGTASVNLSNVL-------KNNGGKMENMQLTLNLQTENKGSVVS 133
            |.|.::|:.....:.:   .||..:|.:.:||       ..:.|:.....:|.:|:..|.|..||
Yeast    64 SILTIQVFDQKKFKKKDQGFLGVVNVRVGDVLGHLDEDTATSSGRPREETITRDLKKSNDGMAVS 128

Human   134 GGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSG 198
            |..:.:.                    |:|||  ||..:.||.......|||. ...:||:.||.
Yeast   129 GRLIVVL--------------------SKLPS--SSPHSQAPSGHTASSSTNT-SSTTRTNGHST 170

Human   199 ASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSV 263
            :|.| ..:|...|.|.    .|.|:::..||          |||               |...:.
Yeast   171 SSTR-NHSTSHPSRGT----AQAVESTLQSG----------TTA---------------ATNTAT 205

Human   264 TPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTW 328
            |.:.:|.|             ::|.|:|              :...|...||
Yeast   206 TSHRSTNS-------------TSSATRQ--------------YSSFEDQYGR------------- 230

Human   329 ERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQR-NQLQG-----AMQHFS 387
               ||||||:|||..||.||||||||||||:|||      .:|.:::| |||..     ..||..
Yeast   231 ---LPPGWERRTDNFGRTYYVDHNTRTTTWKRPT------LDQTEAERGNQLNANTELERRQHRG 286

Human   388 QRFLYQSSSAST--------DHDP-------------------LGPLPPGWEKR-QDNGRVYYVN 424
            :.....||..|:        .:.|                   ||.||.|||:| ...||.|:|:
Yeast   287 RTLPGGSSDNSSVTVQVGGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVD 351

Human   425 HNTRTTQWEDPRTQGMI-----------QEPA-----LPPGWEMKYTSEGVRYFVDHNTRTTTFK 473
            ||||||.|.|||.|..|           |:|.     ||.||||:.|:....|||||||:|||:.
Yeast   352 HNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWD 416

Human   474 DPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPY 538
            |||  ..|...|..| .|.|.||.|...||.......||....|.|.|:.:|||::|:||...|.
Yeast   417 DPR--LPSSLDQNVP-QYKRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPE 478

Human   539 DLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLT 603
            ||::||.|...|||||||||::||:|||||||:.||.||||||:..:||.:||||.|.|||:||.
Yeast   479 DLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLN 543

Human   604 YFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGL 668
            ||:||||.:.:.::|.:|:|..|....||.||.|:..|:|:|.:|.|.|||:.|:.||:::.. |
Yeast   544 YFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGV-L 607

Human   669 ELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAP 733
            :|.|..|.|..|:|.|.:||..|.:|.||:.||:||:.|.|.||....|:||.|||:|||||:.|
Yeast   608 DLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIP 672

Human   734 LEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
            .:.:..|||:||||::.|:.|||:.||:|.|.||.|.::.:.|||||:.|.|.|||:|.|||||.
Yeast   673 EDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFT 737

Human   799 TGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEE 863
            |||.|:||.||.:|.||:||::|.|:|.|:...||:|||||||:|||.|..|:.:::||..|:||
Yeast   738 TGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEE 802

Human   864 TEGFGQE 870
            |.|||||
Yeast   803 TIGFGQE 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	30/137 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299		34/147 (23%)
		Atrophin-1	<164..343	CDD:331285	44/178 (25%)
		WW	302..331	CDD:306827	3/28 (11%)
		WW	332..361	CDD:306827	23/28 (82%)
		WW	407..435	CDD:306827	17/28 (61%)
		WW	447..477	CDD:238122	18/29 (62%)
		HECTc	516..868	CDD:238033	185/351 (53%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	349/915 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I2073
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52003
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850